Вазомаг

General characteristics. Structure:

Active ingredient: meldoniya dihydrate of 250 mg.

Excipients: potato starch, silicon dioxide colloid, calcium stearate.

Structure of a cover of the capsule: titanium dioxide (E171), gelatin.

Pharmacological properties:

The drug improving metabolism and power supply of fabrics. Meldony - a gamma butyrobetaine analog, suppresses gamma бутиробетаингидроксиназу, reduces synthesis of a carnitine and transport of long-chain fatty acids through membranes of cells, interferes with accumulation in cells of the activated forms of unoxidized fatty acids - a derivative acylcarnitine and acylcoenzyme A. In the conditions of ischemia recovers balance of processes of delivery of oxygen and its consumption in cells, prevents disturbance of transport of adenosine triphosphoric acid; along with it activates glycolysis which proceeds without additional consumption of oxygen. As a result of decrease in concentration of a carnitine synthesis of a gamma butyrobetaine which has vasodilating properties amplifies.

The mechanism of action defines variety of pharmacological effects a meldoniya: increase in working capacity, reduction of symptoms of a mental and physical overstrain, activation of fabric and humoral immunity, cardiotyre-tread action. In case of acute ischemic injury of a myocardium slows down formation of a necrotic zone, shortens the rehabilitation period. At heart failure increases contractility of a myocardium, increases tolerance to an exercise stress, reduces the frequency of attacks of stenocardia. At acute and chronic ischemic disorders of cerebral circulation improves blood circulation in the ischemia center, promotes redistribution of blood in favor of the ischemic site. It is effective in case of vascular and dystrophic pathology of an eyeground. Also tonic action on TsNS, elimination of functional disturbances of somatic and vegetative nervous systems at patients with an alcoholism in the period of abstinence is characteristic.

Pharmacokinetics.
Absorption. After intake it is quickly soaked up, bioavailability - 78%. Cmax in a blood plasma is reached in 1-2 h after intake.

Metabolism and removal. It is metabolized in an organism with formation of two main metabolites which are removed by kidneys. T1/2 at intake depends on a dose and makes 3-6 h.

Indications to use:

— in neurology in complex therapy: an ischemic stroke, a hemorrhagic stroke in the recovery period, passing disturbances of cerebral circulation, chronic insufficiency of cerebral circulation;
— in cardiology in complex therapy: Ischemic heart disease (stenocardia, myocardial infarction), chronic heart failure, dishormonal cardiomyopathy;
— the lowered working capacity;
— a physical overstrain, including at athletes;
— the postoperative period for rehabilitation acceleration;
— an abstinence alcoholic syndrome (in a combination with specific therapy).

Route of administration and doses:

Drug is appointed inside.
- At disturbance of cerebral circulation in an acute phase apply an injection form of drug within 10 days then drug is appointed inside on 500 mg / the Course of treatment - 4-6 weeks.
- At chronic disturbances of cerebral circulation - on 500 mg of 1 times/, it is desirable in the first half of day. A course of treatment - 4-6 weeks. Repeated courses - 2-3 times a year.
- In cardiology as a part of complex therapy - on 0.5-1 g / the Course of treatment - 4-6 weeks.
At a cardialgia against the background of dishormonal dystrophy of a myocardium - on 250 mg 2 (in the morning and in the evening). A course of treatment - 12 days.
- At intellectual and physical overworks (including at athletes) the adult - on 250 mg 4 Course of treatment - 10-14 days. If necessary treatment is repeated in 2-3 weeks.
- Before a training - on 0.5-1 g 2, it is desirable in the first half of day. Course duration during the preparatory period - 14-21 days, during competitions - 10-14 days.
- At an abstinence alcoholic syndrome - on 500 mg 4 Course of treatment - 7-10 days.

Features of use:

Influence on ability to driving of motor transport and to control of mechanisms
There are no data on adverse influence of drug on ability to manage vehicles.

Side effects:

Seldom: allergic reactions (skin itch, rashes, reddening and face edema), dyspepsia, tachycardia, excitement, decrease in the ABP.

Interaction with other medicines:

Not to apply along with other dosage forms containing meldoniya (risk of development of side effect).
Strengthens action of koronarodilatiruyushchy and some anti-hypertensive means, cardiac glycosides.
In view of possible development of moderate tachycardia and arterial hypotension, it is necessary to be careful at a combination with nitroglycerine, nifedipine, alpha adrenoblockers, anti-hypertensive means and peripheral vazodilatator.
It is possible to combine with anti-anginal medicines, anticoagulants, antiagregant, antiarrhytmic drugs, diuretics, bronchial spasmolytics.

Contraindications:

— increase in intracranial pressure (at disturbance of venous outflow and intracranial tumors);
— pregnancy;
— period of a lactation (breastfeeding);
— children's age up to 18 years;
— hypersensitivity to drug components.

With care it is necessary to use drug at diseases of a liver and/or kidneys.

Capsule drug VAZOMAG use at pregnancy and feeding by a breast
Drug is contraindicated at pregnancy and during breastfeeding.

Use at abnormal liver functions
With care appoint drug at liver diseases.

Use at renal failures
With care appoint drug at diseases of kidneys.

Use for children
Drug is contraindicated at children's age up to 18 years.

Overdose:

Cases of overdose of drug of Vazomag are not established.

Storage conditions:

List B. Drug should be stored in unavailable to children, dry, the place at a temperature not above 25 °C. A period of validity - 2 years.

Issue conditions:

According to the recipe

Packaging:

Gelatinous solid capsules, size No. 1, white/white color; contents of capsules - powder of white or almost white color.
10 - planimetric strip packagings (2) - packs cardboard.
10 - planimetric strip packagings (4) - packs cardboard.