MV ketoprofen

General characteristics. Structure:

Active ingredient: ketoprofen - 150 mg, excipients: gipromelloza (gidroksipropilmetiltsellyu-rod 15000), calcium hydrophosphate dihydrate, silicon dioxide colloid (aerosil), magnesium stearate.

Description. Tablets of white color, round, biconvex. The insignificant roughness of a surface is allowed. Pharmakoterapevtichesky group

Pharmacological properties:

Pharmacodynamics. Non-steroidal anti-inflammatory drug, has the antiinflammatory, analgeziruyushchy and febrifugal effect connected with suppression of activity of the cyclooxygenases 1 and 2 regulating synthesis of prostaglandins and bradikinin; stabilizes lizosomalny membranes. Does not exert negative impact on a condition of a joint cartilage.

Pharmacokinetics. Absorption - bystry, bioavailability - more than 90%. Communication with proteins of plasma - 99%. The minimum effective concentration is defined in 45-60 min. At oral administration of tablets of ketoprofen the maximum concentration of drug in plasma is reached in 1 h. Therapeutic concentration in synovial fluid remains 6-8 h. In significant quantity does not get through a blood-brain barrier. It is almost completely metabolized in a liver by a glyukuronirovaniye, has effect of "the first passing" through a liver. It is removed by kidneys (mainly in the form of a ketoprofen glucuronide) and intestines (1%). An elimination half-life - 1,6-1,9 h. Does not kumulirut.

Indications to use:

Inflammatory and degenerative diseases of a musculoskeletal system: rhematoid, psoriasis arthritis, Bekhterev's disease (ankylosing spondylitis), gouty arthritis, osteoarthrosis. Drug is intended for symptomatic therapy, reduction of pain and an inflammation at the time of use, does not influence progressing of a disease. Pain syndrome: a mialgiya, an ossalgiya, neuralgia, a tendinitis, an arthralgia, a bursitis, radiculitis, an adnexitis, otitis, head and a dentagra, at oncological diseases; the posttraumatic and postoperative pain syndrome which is followed by an inflammation, альгодисменорея.

Route of administration and doses:

Inside, in time or after food, on 1 tablet (100 mg) 2 times a day. Tablets should be swallowed entirely, without chewing, washing down with a large amount (not less than 100 ml) of water or milk. It is necessary to use a minimal effective dose minimum possible short course.

Features of use:

Ketoprofen can be washed down with milk or to accept with antiacid drugs for the purpose of reduction of frequency of gastrointestinal frustration; antiacid drugs and milk do not influence absorbability of drug. During treatment control of a picture of peripheral blood and a functional condition of a liver and kidneys, especially at patients of advanced age is necessary. At a renal failure and a liver the dose decline and careful observation is necessary. In need of definition of 17 ketosteroids drug should be cancelled for 48 h prior to a research. Administration of drug can mask symptoms of an infectious disease. It is not necessary to use drug along with other NPVP. During treatment it is necessary to be careful during the driving of motor transport and occupation other potentially dangerous types of activity demanding the increased concentration of attention and speed of psychomotor reactions.

Side effects:

From the alimentary system: often - dyspepsia (nausea, diarrhea or a lock, a meteorism, vomiting, heartburn, a loss of appetite) the NPVP-gastropathy, an abdominal pain, stomatitis, an abnormal liver function; seldom - perforation of bodies of digestive tract, an exacerbation of a disease Krone, a melena, gingival, gastrointestinal, hemorrhoidal bleeding.

From the central nervous system: often - a headache, dizziness, sleeplessness, drowsiness, fatigue, excitement, nervousness, a depression, an adynamy; seldom - confusion or a loss of consciousness, forgetfulness, migraine, a peripheral neuropathy; very seldom - hallucinations, a disorientation and an alalia.

From sense bodys: seldom - noise or a ring in ears, an illegibility of visual perception, taste change, conjunctivitis, decrease in hearing, dryness of a mucous membrane of an eye, eye pain, a conjunctiva hyperemia, вертиго.

From CCC: seldom - tachycardia, arterial hypertension, peripheral hypostases. From bodies of a hemopoiesis: ketoprofen reduces aggregation of thrombocytes, tranzitorny increase in level of enzymes of a liver, is rare - an agranulocytosis, anemia, thrombocytopenia, a purpura, hemolitic anemia, a leukopenia.

From an urinary system: seldom - a renal failure, cystitis, an urethritis, intersticial nephrite, a nephrotic syndrome, a hamaturia (develop at people more often, it is long accepting NPVP and diuretics). Allergic reactions: often - skin reactions (an itch, urticaria); seldom - rhinitis, short wind, a bronchospasm, a Quincke's disease, anaphylactoid reactions, exfoliative dermatitis. Other: sweating strengthening, is rare - a pneumorrhagia, nasal bleeding, a menometrorrhagia, muscular twitchings, thirst, a photosensitization.

Interaction with other medicines:

Ketoprofen can weaken effect of diuretics and antihypertensives and to strengthen effect of peroral hypoglycemic and some anticonvulsant drugs (Phenytoinum). Joint reception with other NPVP, glucocorticosteroids, salicylates, ethanol, corticotropin increases risk of development of the undesirable phenomena from digestive tract. Co-administration with anticoagulants, trombolitika, antiagregant, and also with tsefaperazony, tsefamandoly, tsefotetany and a moxalactam increases risk of development of bleedings. At a concomitant use of non-steroidal anti-inflammatory drugs with diuretics and APF inhibitors the risk of a renal failure increases. Increases concentration in plasma of cardiac glycosides, blockers of slow calcium channels, drugs of lithium, cyclosporine, a methotrexate. Non-steroidal anti-inflammatory drugs can reduce efficiency of mifepristone. Reception of NPVP should be begun not earlier than in 8-12 days after mifepristone cancellation. Inductors of a microsomal oxidation in a liver (Phenytoinum, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase products of hydroxylated active metabolites. Joint appointment with Valproatum of sodium causes disturbance of aggregation of thrombocytes. Increases hypoglycemic effect of insulin and peroral hypoglycemic HP (recalculation of a dose is necessary). Myelotoxic HP strengthen manifestations of a gematotoksichnost of drug.

Contraindications:

Hypersensitivity to ketoprofen and other components of drug, and also to other non-steroidal anti-inflammatory drugs. The bronchial asthma, rhinitis or a small tortoiseshell in the anamnesis called by reception of acetylsalicylic acid or other NPVP. Peptic ulcer of a stomach and/or 12-perstny gut (aggravation stage), ulcer colitis (aggravation stage), disease Krone; hemophilia and other disturbances of a blood coagulation; the confirmed hyperpotassemia; diverticulitis, round ulcer, active gastrointestinal bleeding, inflammatory diseases of intestines; dekompensirovanny heart failure, the period after performing aortocoronary shunting; heavy liver failure or active disease of a liver; a heavy renal failure (KK less than 30 ml/min.), the progressing diseases of kidneys; children's age (up to 12 years); pregnancy (III trimester), breastfeeding period.

Overdose:

Symptoms. At overdose by ketoprofen, as well as other non-steroidal anti-inflammatory drugs, nausea, vomiting, vomiting with blood, abdominal pains, a melena, consciousness disturbance, respiratory depression, spasms, a renal failure and a renal failure can be noted. There is no specific antidote.

Treatment - symptomatic. Impact of ketoprofen on digestive tract can be weakened by means of antagonists of H2 receptors, inhibitors of a proton pomp and prostaglandins. The gastric lavage and use of absorbent carbon is shown.

Storage conditions:

List B. In the dry, protected from light place, at a temperature not above 25 °C. To store in the place, unavailable to children.

Issue conditions:

According to the recipe

Packaging:

Tablets, 100 mg. On 20 tablets in the bottle of dark glass corked by a cover. On 1 bottle together with the application instruction in a pack from a cardboard.