Vinpocetine

General characteristics. Structure:

Active agent: 1 tablet contains - a Vinpocetine (in terms of 100% substance) 5 mg or 10 mg;

excipients: lactoses monohydrate, cellulose microcrystallic, potato starch, aerosil, macrogoal 4000 (polyethyleneglycol 4000), magnesium stearate, sodium of a kroskarmelloz.

Pharmacological properties:

Pharmacodynamics. The Vinpocetine improves blood circulation and metabolic processes in a brain, increases portability of ischemia of a brain. The effect is implemented at the expense of the complex mechanism of action. Selectively and intensively strengthens a brain blood stream and cerebral fraction of minute volume of blood, reduces brain vascular resistance, without influencing parameters of system blood circulation (arterial pressure, minute volume of blood, pulse rate, the general peripheric resistance of vessels). Strengthens, first of all, blood supply of the struck, ischemic area of a brain, without causing a phenomenon of "burglarizing", at the same time blood supply of intact area does not change. Improves microcirculation in a brain, slows down aggregation of thrombocytes, reduces the increased viscosity of blood, increases elasticity of erythrocytes and blocks absorption of adenosine by them. Increases portability of a hypoxia brain cells, promoting oxygen transport to fabrics. Strengthens absorption and metabolism of glucose which switches to energetically more favorable aerobic way, stimulates anaerobic metabolism of glucose by braking of phosphodiesterase and activation of adenylatecyclase that leads to increase in concentration of tsAMF and catecholamines in a brain.

Pharmacokinetics. At use inside it is quickly soaked up in digestive tract; bioavailability makes 70%. The maximum concentration in blood is reached in 1 h. Easily gets through gistogematichesky barriers, including through a blood-brain barrier. It is metabolized in a liver with formation of several metabolites, the apovinkaminovy acid and a hydroxyvinpocetine having pharmacological activity are basic of which. It is excreted with urine and bile, generally in the form of the metabolites conjugated with glucuronic acid. The elimination half-life makes to 5 h.

Indications to use:

The diseases, arising owing to insufficiency of cerebral circulation (tranzitorny ischemia, an ischemic stroke, states after a stroke, a cherepnomozgovy injury, multiinfarctive dementia, atherosclerosis of cerebral arteries, posttraumatic and hypertensive encephalopathy) and which are followed by mental and neurologic disorders (memory disturbance, dizziness, a headache, aphasia, apraxia, motive frustration), vertebro-basilar insufficiency. The vascular diseases of eyes first of all caused by a vasomotor spasm of a choroid and a retina (including degenerative diseases of a choroid, a retina or a macula lutea; secondary glaucoma; arterial and venous fibrinferments or embolisms). Deterioration in hearing of vascular or toxic genesis, senile glukhovatost, Menyer's disease, kokhleovestibulyarny neuritis, dizzinesses of a labyrinth origin. Vazovegetativny symptoms of a climacteric.

Route of administration and doses:

The Vinpocetine in the form of tablets is accepted after food. The adult usually appoint 5-10 mg of a Vinpocetine 3 times a day. The maximum daily dose – 30 mg a day. A course of treatment – from 1 to 3-4 months depending on therapeutic effect. Before drug withdrawal its dose is reduced within 2-3 days.

Features of use:

It is necessary to be careful at appointment as the patient with bradycardia at which on an ECG lengthening of an interval of QT is observed. At a hemorrhagic cerebral stroke treatment by drug is admissible only after subsiding of the acute phenomena (usually in 5-7 days). Sensitivity of brain vessels to the running-down effect of drug increases in advanced and senile age that is caused by a sensitization when aging system adenylatecyclase-tsAMR. In case of sensitivity to lactose it is necessary to consider that each tablet on 5 mg of the drug Vinpocetine contains 67,3 mg of lactose, and on 10 mg – 134,6 mg of lactose. Owing to absence the Vinpocetine gepato-and nephrotoxic action, has no need to adjust a dose at patients with diseases of a liver and kidneys. Data on use of a Vinpocetine at children's age are not enough.

Side effects:

Drug is usually well transferred, but at some patients are possible:
from cardiovascular system: tachycardia, arrhythmia;
from the alimentary system: nausea, heartburn, dryness in a mouth;
from the central nervous system: sleep disorder, headache, dizziness, weakness;
others: dermahemia, allergic skin reactions.

Interaction with other medicines:

About interaction of a Vinpocetine with other medicines data are absent.

Contraindications:

Severe form of coronary heart disease, difficult disturbances of a heart rhythm, pregnancy, feeding by a breast, individual sensitivity to a Vinpocetine.

Overdose:

Cases of overdose are not registered.

Issue conditions:

According to the recipe

Packaging:

 Tablets of 5 mg, 10 mg No. 10*3.