Acyclovir

General characteristics. Structure:

Deystvyushchy substance - an acyclovir - 50 mg. Excipients - poly(ethylene oxide) 400, poly(ethylene oxide) 1500. Description. Homogeneous ointment of white color, almost inodorous.

Pharmacological properties:

The acyclovir is active concerning the Herpes simplex 1 and 2 viruses of types; virus, Varicella zoster, Epstein-Barre's virus and cytomegaloviruses. The thymidinekinase of the cells infected with a virus through a number of consecutive reactions actively will transform an acyclovir to mono - di - and acyclovir triphosphate. The last interacts with a virus DNA polymerase and is built in DNA, kotoroy is synthesized for new viruses. Thus, "defective" virus DNA forms that leads to suppression of replications of new generations of viruses. Pharmacokinetics. At local use it is practically not soaked up through the injured skin, does not get to a system blood stream.

Indications to use:

Infections of skin and the mucous membranes caused by the Herpes simplex virus of types 1 and 2, genital herpes, shingles, chicken pox.

Route of administration and doses:

Outwardly. Drug is applied by 5 times a day (each 4 h) with a thin layer on the sites of skin struck and adjoining on them. Ointment is applied either a cotton plug, or clean hands to avoid additional infection of affected areas. Therapy should be continued till that time while on bubbles the crust is not formed or until completely heal. Duration of therapy averages 5 days and should not exceed 10 days.

Features of use:

For achievement of the maximum therapeutic effect it is necessary to begin to use drug as soon as possible after the beginning of an infection (at the first symptoms of a disease: burning, itch, pricking, feeling of tension and reddening). Ointment is not recommended to be applied on mucous membranes of an oral cavity and eyes as development of the expressed local inflammation is possible. At treatment of genital herpes it is necessary to avoid sexual contacts or to use condoms as use of an acyclovir does not prevent transfer of a virus to partners.

Side effects:

Hyperemia, dryness, skin peeling, burning, inflammation at hit on mucous membranes. Development of allergic dermatitis is possible.

Interaction with other medicines:

At external use interaction with other medicines is not revealed.

Contraindications:

Hypersensitivity to an acyclovir and other components of drug. With care - pregnancy, the lactation period, dehydration, a renal failure.

Storage conditions:

At a temperature not above 25 °C, in the dry, protected from light place and the place, unavailable to children. To store in the place, unavailable to children. Period of validity. 2 years. Not to use after expiry date.

Issue conditions:

Without recipe

Packaging:

5% ointment for external use in tubas aluminum on 10 g. Together with the application instruction place in a pack from a cardboard.