Izopask

General characteristics. Structure:

Active ingredients: 1,145 g of sodium of para-aminosalicylate and 0,033 g of an isoniazid.

Excipients: ethyl cellulose, cellulose microcrystallic, povidone, sodium krokhmalglikolit (type A), dioxide of kolloidniya is more waterless than silicon, talc, magnesium stearate, a gidroksipropilmetiltsellyuloz (gipromeloz), diethyl phthalate, polyethyleneglycol 6000, triethyl citrate, titanium dioxide (E171), metakrylatny copolymer, FCF "yellow decline" dye (Е 110).

Antimicrobic drug for system use of the antitubercular direction.

Pharmacological properties:

Pharmacodynamics. The antituberculous combined remedy; deystvuyetbakteritsidno (due to oppression of synthesis of the mikoliyevy acids which are the most important component of a cell wall of mycobacteria) and bacteriostatically (due to the competition to PABK and suppression of synthesis of folate in tuberculosis mycobacteria). The paraaminosalicylate which is a part of sodium slows down development of resistance to an isoniazid, slows down acetylation, competes with an isoniazid for the liver N-acetyltransferase metabolizing these drugs that leads to increase in concentration of GINK in blood.

Pharmacokinetics. Drug is well soaked up at intake. The maximum concentration of active components at reception of a single dose is noted in 1-2 hours. Are well distributed on all organism. It is metabolized in a liver, in urine is defined in the form of acetylized inactive metabolites. The general clearance depends as on the metabolism speed, and removal by kidneys. Small amounts are allocated with excrements.

Indications to use:

Tuberculosis (various forms and localizations), as a part of complex therapy, including for treatment of patients with resistant forms.

Route of administration and doses:

Inside, after food, washing down with a large amount (150 ml) of water 1-3 tablets 4 times a day.

Features of use:

At treatment it is recommended to control activity of "hepatic" transaminases. Depression of function of kidneys against the background of tubercular intoxication or specific defeat are not a contraindication to appointment. At emergence of symptoms of toxic hepatitis, development of a proteinuria and hamaturia temporary drug withdrawal is required.

Side effects:

Loss of appetite, nausea, vomiting, meteorism, abdominal pain, diarrhea or locks, hepatomegalia, increase in activity of "hepatic" transaminases, hyperbilirubinemia; proteinuria, hamaturia, crystalluria. Seldom - thrombocytopenia, a leukopenia (up to an agranulocytosis), medicinal hepatitis, B12 - scarce megaloblastny anemia. Allergic reactions - fever, dermatitis (a small tortoiseshell, a purpura, an enantema), an eosinophilia, a bronchospasm. At prolonged use in high doses - a hypothyroidism, a craw, a myxedema.

Interaction with other medicines:

With care it is necessary to combine with potentially neuro, gepato-and nefrotoksichny medicines because of danger of strengthening of side effect. Strengthens effect of coumarin and an indandion, benzodiazepines, theophylline. Glucocorticosteroids accelerate metabolism of drug in a liver and reduce active concentration in blood. Breaks rifampicin absorption (it is appointed not earlier than in 4 hours after rifampicin reception), erythromycin.

Contraindications:

Hypersensitivity, renal failure, liver failure, hepatitis, cirrhosis; an amyloidosis of internals, a peptic ulcer of a stomach and a 12-perstny gut, a coloenteritis (aggravation), a myxedema (noncompensated), nephrite, dekompensirovanny HSN (including against the background of heart disease), thrombophlebitis, hypocoagulation, pregnancy, a lactation.

Overdose:

Symptoms: dizziness, a dysarthtia, slackness, a disorientation, a hyperreflexia, a peripheral polyneuropathy, an abnormal liver function, a metabolic acidosis, a hyperglycemia, a glucosuria, a ketonuria, spasms (in 1-3 h after drug use), a coma.

Storage conditions:

To store at a temperature not over 25 ºС, in the dry, protected from light place unavailable to children.

Issue conditions:

According to the recipe

Packaging:

The tablets covered with an enterosoluble cover on 100, 372 or 500 tablets in a polymeric can.