Ascorbic acid

General characteristics. Structure:

Active ingredient: 25 mg of ascorbic acid in each tablet.

Pharmacological properties:

Pharmacodynamics. Ascorbic acid fills shortage of vitamin C in an organism, has metabolic, antioxidant effect, participates in regulation of oxidation-reduction processes, carbohydrate metabolism, coagulability of blood, an angenesis. Supports hydrogen transport in many biochemical reactions. Regulates colloidal state of intercellular substance, effect of hyaluronidase oppresses and maintains normal permeability of capillaries. Activates proteolytic enzymes, participates in exchange of aromatic amino acids and in pigmental exchange, regulates the content of cholesterol in blood, promotes accumulation in a glycogen liver. Participates in iron metabolism. Improves bile secretion, recovers vneshnesekretorny function of a pancreas and incretory function of a thyroid gland. Regulates immunological reactions, promotes phagocytosis, increases body resistance to infections.

Indications to use:

Treatment and prevention hypo - and avitaminosis of C. Conditions of the increased need for ascorbic acid. The period of artificial feeding and intensive growth, unbalanced food, the raised intellectual and exercise stresses, the reconvalescence period after a serious illness, alcoholism, a burn disease, a feverish state against the background of an acute respiratory disease, an acute respiratory and viral infection; it is long the current persistent infections, nicotine addiction, a stressful state, the postoperative period, pregnancy (polycarpous, against the background of nicotine or medicinal addiction). Chronic intoxication iron preparations (as a part of complex therapy with Deferoxaminum). Idiopathic methemoglobinemia.

Route of administration and doses:

Inside, after food for prevention on 50-100mg 1 times a day, during pregnancy and a puerperal period and in case of the low content of vitamin C in milk of the feeding women appoint 300 mg a day within 10-15 days then preventively - on 100 mg a day during the entire period of a lactation. Medical doses for adults make at intake of 50-100mg 3-5 times a day.

To children appoint inside 50-100mg 2-3 times a day. Terms of treatment depend on character and the course of a disease.

Features of use:

At prolonged treatment it is necessary to control function of kidneys, level of arterial pressure and concentration of glucose in blood.

At patients with the increased content of iron in an organism ascorbic acid should be applied in the minimum doses.

Side effects:

Arterial hypertension, vitamin C hypervitaminosis, disbolism, oppression of function of the insulyarny device of a pancreas (hyperglycemia, glucosuria) and synthesis of a glycogen, decrease in permeability of capillaries, deterioration in a trophicity of fabrics, thrombocytosis, erythropenia, giperprotrombinemiya, neutrophylic leukocytosis, damage of the glomerular device of kidneys, allergic reactions.

At long reception formation of urinary stones, disturbance of exchange of zinc, copper, increase in excitability of the central nervous system, a sleep disorder, development of mikroangiopatiya is possible.

Interaction with other medicines:

At simultaneous use with salicylates ascorbic acid increases their concentration in blood and increases risk of development of a crystalluria. Increases level in blood of ethinylestradiol, benzylpenicillin and tetracyclines, reduces the level of oral contraceptives. Improves absorption in intestines of iron preparations. Increases the general clearance of alcohol. Reduces efficiency of heparin and indirect anticoagulants. Drugs of a quinolinic row, Calcii chloridum, salicylates, glucocorticosteroids at prolonged use exhaust reserves of ascorbic acid.

At simultaneous use reduces chronotropic action of an izoprenalin. In high doses increases removal of a meksiletin kidneys. Barbiturates and Primidonum increase removal of ascorbic acid with urine. Reduces therapeutic action of neuroleptics – derivatives of a fenotiazin, a canalicular reabsorption of amphetamine and tricyclic antidepressants.

Contraindications:

Hypersensitivity, thrombophlebitis, tendency to fibrinferments, diabetes mellitus.

With care appoint at deficit glyukozo-6-fosfatdegidrogenazy, hemochromatosis, sideroblastny anemia, a thalassemia, a hyperoxaluria, an oxarod, a nephrolithiasis.

Overdose:

Symptoms: at prolonged use of high doses (more than 1000 mg of ascorbic acid) – a headache, increase in excitability of the central nervous system, sleeplessness, decrease in permeability of capillaries (deterioration in a trophicity of fabrics, increase in arterial pressure, hypercoagulation, development of mikroangiopatiya is possible), oppression of function of the insulyarny device of a pancreas (a hyperglycemia, a glucosuria), a hyperoxaluria, a nephrolithiasis, damage of the glomerular device of kidneys.

Treatment: drug withdrawal. To see a doctor. Symptomatic therapy is shown.

Issue conditions:

Without recipe

Packaging:

Tablets of 25 mg in a blister strip packaging No. 10 or in bottles No. 40.