DE   EN   ES   FR   IT   PT Medicines Vitamins. Ascorbic acid. Rostvit


Препарат Роствит. ЗАО "ФП "ОБОЛЕНСКОЕ" Россия

General characteristics. Structure:

Active ingredient: 0,5 g of ascorbic acid in 1 tablet.

Excipients: декстрат, Mannitolum, кросповидон, aspartame, magnesium stearate, talc, fragrance ("orange").

Vitamin means, increases resistance of an organism to infections.

Pharmacological properties:

Pharmacodynamics. Vitamin means, has metabolic effect, is not formed in a human body, and arrives only with food. Participates in regulation of oxidation-reduction processes, carbohydrate metabolism, coagulability of blood, an angenesis; increases resistance of an organism to infections, reduces vascular permeability, reduces the need for B1, B2, A, E vitamins, folic acid, pantothenic acid.

Participates in metabolism of phenylalanine, tyrosine, folic acid, Norepinephrinum, histamine, Fe, utilization of karbogidrat, synthesis of lipids, proteins, a carnitine, immune responses, a serotonin hydroxylation, strengthens absorption of negeminovy Fe.

Has the antiagregantny and expressed antioxidant properties.

Regulates H+ transport in many biochemical reactions, improves use of glucose in a cycle of tricarboxylic acids, participates in formation of tetrahydrofolic acid and an angenesis, synthesis of steroid hormones, collagen, procollagen.

Maintains colloidal state of intercellular substance and normal permeability of capillaries (oppresses hyaluronidase).

Activates proteolytic enzymes, participates in exchange of aromatic amino acids, pigments and cholesterol, promotes accumulation in a glycogen liver. Due to activation of respiratory enzymes in a liver strengthens its disintoxication and belkovoobrazovatelny functions, increases synthesis of a prothrombin.

Improves bile secretion, recovers vneshnesekretorny function of a pancreas and incretory - thyroid.

Regulates immunological reactions (activates synthesis of antibodies, C3 component of a complement, interferon), promotes phagocytosis, increases body resistance to infections.

Slows down release and accelerates degradation of a histamine, formation of Pg, etc. mediators of an inflammation and allergic reactions oppresses.

In low doses (150-250 mg/days inside) improves complexing function of Deferoxaminum at chronic intoxication iron preparations that leads to strengthening of excretion of the last.

Pharmacokinetics. It is absorbed in a GIT (preferential in a jejunum). With increase in a dose up to 200 mg about 140 mg (70%) are soaked up; at further increase in a dose absorption decreases (50-20%). Communication with proteins of plasma – 25%. Gastrointestinal diseases (a peptic ulcer of a stomach and a 12-perstny gut, locks or diarrhea, a helminthic invasion, a lambliasis), the use of fresh fruit and vegetable juice, alkaline drink reduce absorption of an ascorbate in intestines.

Concentration of ascorbic acid in plasma normal makes about 10-20 mkg/ml, stocks in an organism - about 1,5 g at reception of the daily recommended doses and 2,5 g at reception of 200 mg/days of TCmax after intake – 4 h.

Easily gets into leukocytes, thrombocytes, and then - into all fabrics; the greatest concentration is reached in ferruterous bodies, leukocytes, a liver and lens; it is deposited in a back share of a hypophysis, bark of adrenal glands, an eye epithelium, interstitial cells of seminal glands, ovaries, a liver, a spleen, a pancreas, lungs, kidneys, an intestines wall, heart, muscles, a thyroid gland; gets through a placenta. Concentration of ascorbic acid in leukocytes and thrombocytes is higher, than in erythrocytes and in plasma. At scarce states concentration in leukocytes decreases later and more slowly and is considered as the best criterion for evaluation of deficit, than concentration in plasma.

It is metabolized preferential in a liver in dezoksiaskorbinovy and further in oxalacetic and diketogulonic acids.

It is removed by kidneys, through intestines, with then, breast milk in the form of not changed ascorbate and metabolites.

At purpose of high doses removal speed sharply amplifies. Smoking and the use of ethanol accelerate destruction of ascorbic acid (transformation into inactive metabolites), sharply reducing stocks in an organism.

It is removed at a hemodialysis.

Indications to use:

Treatment and prevention hypo - and avitaminosis of C. Conditions of the increased need for ascorbic acid: for increase in protective forces of an organism in complex therapy of a SARS, "catarrhal diseases", the recovery period after long diseases, asthenic states, long overcooling of an organism, unbalanced food, hard work, alcoholism, smoking, a long stressful state, long fever, persistent infections, gastrointestinal diseases (persistent diarrhea, a resection of a small intestine, a round ulcer, a gastrectomy), the postoperative period, injuries, tuberculosis, a hyperthyroidism.

Chronic intoxication iron preparations. Idiopathic methemoglobinemia.

Route of administration and doses:

Inside, after food. To chew a tablet. Drug is recommended for use for adults and children from 14 years.

For prevention of a hypovitaminosis With: 1 tablet (500 mg) once a day within 10 days; a break between courses of treatment not less than 1 month.

With the medical purpose: 1 tablets once a day within 14 days. A break between courses of treatment not less than 1 month.

Features of use:

Products rich with ascorbic acid: citrus, greens, vegetables (pepper, broccoli, headed cabbage, tomatoes, potatoes). At storage of products (including long freezing, drying, a pickles, pickling), cooking (especially in copper ware), crushing of vegetables and fruit in salads, preparation of puree there is a partial destruction of ascorbic acid (at temperature processing - to 30-50%).

In connection with a promoting effect of ascorbic acid on synthesis of corticosteroid hormones it is necessary to monitor function of adrenal glands and the ABP.

At prolonged use of high doses oppression of function of the insulyarny device of a pancreas therefore in the course of its treatment it is regularly necessary to control is possible.

At patients with the increased content of iron in an organism it is necessary to apply ascorbic acid in the minimum doses.

Now consider unproven efficiency of use of ascorbic acid for prevention of diseases CCC and some types of malignant tumors.

Ascorbic acid is not recommended to be applied at a pyorrhea, infectious diseases of gums, the hemorrhagic phenomena, a hamaturia, an eye retinal apoplexy, disturbances of immune system, the depression which is not connected with deficit of vitamin C.

Drug is considered insufficiently effective at treatment of anemia, vulgar eels, bronchial asthma, infertility, atherosclerosis, a round ulcer, tuberculosis, schizophrenia, dysentery, kollagenoz, cankers of skin, hay fever, changes, medicinal intoxication, the general overcooling, for prevention of thromboses.

Purpose of ascorbic acid to patients with quickly proliferating and intensively metastasizing tumors can aggravate the course of process.

Ascorbic acid as a reducer can distort results of various laboratory tests (content in blood of glucose, bilirubin, activity of "hepatic" transaminases and LDG).

The minimum daily need for ascorbic acid for the II-III trimesters of pregnancy - about 60 mg. It must be kept in mind that the fruit can adapt to high doses of ascorbic acid which is accepted by the pregnant woman, and then at the newborn development of a syndrome of "cancellation" is possible.

The minimum daily requirement in the period of a lactation – 80 mg. Mother's diet containing adequate amount of ascorbic acid is sufficient for prevention of deficit at the baby. Theoretically there is a danger to the child at use by mother of high doses of ascorbic acid (it is recommended not to exceed the nursing mother of daily need for ascorbic acid).

Side effects:

From the alimentary system: at intake - irritation of a mucous membrane of a GIT. Allergic reactions: skin rash, dermahemia.

Laboratory indicators: thrombocytosis, giperprotrombinemiya, erythropenia, neutrophylic leukocytosis, hypopotassemia.

Intensive consumption of chewable tablets or rassasyvaniye of peroral forms can cause damage of an adamantine substance of tooth.

Interaction with other medicines:

Increases concentration in blood of benzylpenicillin and tetracyclines; in a dose of 1 g/days increases bioavailability of ethinylestradiol (including being a part of oral contraceptives).

Improves absorption in intestines of iron preparations (transfers trivalent iron to bivalent); can increase removal of iron at simultaneous use with Deferoxaminum.

Reduces efficiency of heparin and indirect anticoagulants.

ASK, oral contraceptives, fresh juice and alkaline drink reduce absorption and assimilation.

At simultaneous use with ASK removal with urine of ascorbic acid increases and removal of ASK decreases.

ASK reduces absorption of ascorbic acid approximately by 30%.

Increases risk of development of a crystalluria at treatment by salicylates and streptocides of short action, slows down removal by kidneys of acids, increases removal of the HP having alkali reaction (including alkaloids), reduces concentration in blood of oral contraceptives.

Increases the general clearance of ethanol which in turn reduces concentration of ascorbic acid in an organism.

The HP of a quinolinic row, CaCl2, salicylates, GKS at prolonged use exhaust reserves of ascorbic acid.

At simultaneous use reduces chronotropic action of an izoprenalin.

At prolonged use or use in high doses Disulfiramum ethanol can break interaction.

In high doses increases removal of a meksiletin kidneys.

Barbiturates and Primidonum increase removal of ascorbic acid with urine.

Reduces therapeutic action of antipsychotic HP (neuroleptics) - derivatives of a fenotiazin, a canalicular reasorbtion of amphetamine and tricyclic antidepressants.



With care: diabetes mellitus, deficit glyukozo-6-fosfatdegidrogenazy; for use in high doses - hemochromatosis, sideroblastny anemia, a thalassemia, a hyperoxaluria, oxarods, a nephrolithiasis.


Symptoms: at prolonged use of high doses (more than 1 g) - a headache, increase in excitability TsNS, sleeplessness, nausea, vomiting, diarrhea, hyperacid gastritis, an ultseration of a mucous membrane of a GIT, oppression of function of the insulyarny device of a pancreas (a hyperglycemia, a glucosuria), a hyperoxaluria, a nephrolithiasis (from oxalate calcium), damage of the glomerular device of kidneys, a moderate pollakiuria (at reception of a dose more than 600 mg/days).

Decrease in permeability of capillaries (deterioration in a trophicity of fabrics, increase in the ABP, hypercoagulation, development of mikroangiopatiya is possible).

Storage conditions:

In the dry place protected from light at a temperature not above 25 °C. A period of validity - 1 year.

Issue conditions:

Without recipe


Tablets chewing 500 mg. On 10 tablets in a plastic tuba. On 1 tuba with the application instruction in a pack from a cardboard.

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