Glucose Bufus

General characteristics. Structure:

Active ingredient: 400 mg of a dextrose monohydrate (in terms of dry matter of a dextrose).

Excipients: Acidum hydrochloricum (0,1 M Acidum hydrochloricum solution), sodium chloride, water for injections.

Pharmacological properties:

Pharmacodynamics. Glucose strengthens oxidation-reduction processes in an organism, improves anti-toxic function of a liver, covers a part of power expenses of an organism as is a source of digestible carbohydrates. Coming to fabrics it is phosphorylated, turning into glyukozo-6-phosphate which actively joins in many links of a metabolism of an organism.

Solution of 400 mg/ml is hypertensive. At introduction to a vein of hypertonic salt solution the osmotic pressure of blood increases, sokratitelny activity of a cardiac muscle amplifies, vessels extend, detoksikatsionny function of a liver improves, the diuresis increases.

Pharmacokinetics. It is acquired completely by an organism, by kidneys it is not removed (emergence in urine is a pathological sign).

Indications to use:

Hypoglycemia, insufficiency of carbohydrate food, toxicoinfection, intoxications at liver diseases (hepatitis, dystrophy and a hepatatrophia, including a liver failure), hemorrhagic diathesis; intoxication; collapse, shock.

As component of various blood-substituting and antishock liquids; for preparation of solutions of medicines for intravenous administration.

Route of administration and doses:

Intravenously kapelno – up to 30 caps/min. (1,5 ml/min.); the maximum daily dose for adults – 250 ml.

For fuller assimilation of the dextrose entered in high doses along with it appoint insulin at the rate of 1 PIECE of insulin to 4-5 g of a dextrose. Sick diabetes the dextrose is entered under control of its content in blood and urine.

Features of use:

It is impossible to enter solution of glucose quickly or a long time. If in the course of infusion of solution there is a fever, introduction should be stopped immediately. For prevention of thrombophlebitis, solution should be entered slowly, through large veins.

At a combination with other medicines it is necessary to control compatibility visually.

Sick diabetes mellitus the dextrose is entered under control of its content in blood and urine.

Side effects:

Disturbances of ionic balance, hyperglycemia, glucosuria, fever, hypervolemia, acute left ventricular failure. In an injection site – development of an infection, thrombophlebitis.

Interaction with other medicines:

At a combination with other medicines it is necessary to control visually compatibility (invisible pharmaceutical or pharmakodinamichesky incompatibility is possible).

Contraindications:

Hypersensitivity, hyperglycemia, hyper lactacidemia, overhydratation, postoperative disturbances of utilization of glucose; the circulator disturbances menacing with wet brain and lungs; wet brain, fluid lungs, acute left ventricular failure, giperosmolyarny coma, children's age.

With care – dekompensirovanny chronic heart failure, a chronic renal failure (oligo-, an anury), a hyponatremia, a diabetes mellitus.

Overdose:

Symptoms: hyperglycemia, glucosuria, hyper glycemic giperosmolyarny coma, overhydratation, disturbance of water and electrolytic balance. Treatment: to stop administration of glucose, to enter insulin, symptomatic therapy.

Storage conditions:

At a temperature from 5 to 30 °C. To store in the place, unavailable to children. A period of validity - 5 years in ampoules of neutral glass, 3 years in ampoules polymeric. Not to apply after the period of validity specified on packaging.

Issue conditions:

According to the recipe

Packaging:

Solution for intravenous administration of 400 mg/ml. On 5 ml, 10 ml in ampoules of neutral glass or in ampoules polymeric of polyethylene of high pressure, or from polyethylene of low pressure, or from polyethylene for the medical purposes, or from polyethylene or polypropylene for infusion solutions and injection drugs.

On 10 ampoules of neutral glass with the application instruction place in a box from a cardboard with a corrugated insert from paper renal. Put a knife in each box ampoule or the scarificator. When packaging ampoules with notches, rings and points ampoule or scarificators do not put knives. On 10 ampoules polymeric with the application instruction place in a pack from a cardboard.