Glucose of 7,5%

General characteristics. Structure:

Active ingredient: 75 g of glucose in 1 l of infusion solution in terms of anhydrous, 0,26 g of sodium of chloride.

Pharmacological properties:

Pharmacodynamics. Glucose belongs to monosugars. It has high energy value and at her metabolism in an organism a significant amount of energy which is used for ensuring power supply of all functions of an organism is allocated. Glucose participates in regulation of oxidation-reduction processes in an organism, improves detoksikatsionny function of a liver, increases sokratitelny activity of a myocardium. The concentrated (hypertensive) solutions of glucose have the expressed osmotic effect. At introduction to a vein of solution of glucose of 7,5% for infusions liquid current from fabrics in a circulatory bed amplifies and there is their dehydration. Hypertonic salt solution of glucose promotes vasodilatation and raises a diuresis.

Pharmacokinetics. At intravenous administration glucose quickly gets to fabrics where it is completely metabolized. At intravenous administration of large volumes of solution of glucose of 7,5% for infusions emergence of a glucosuria in patients is possible.

Indications to use:

- Hypoglycemia,
- insufficiency of carbohydrate food,
- toxicoinfection, intoxications at liver diseases (hepatitis, dystrophy and a hepatatrophia, including a liver failure),
- hemorrhagic diathesis;
- dehydration (vomiting, diarrhea, postoperative period);
- intoxication;
- collapse,
- shock.

Solution of glucose of 7,5% can be applied to infusions as independent drug, and also in combination with other medicines (methylene blue, ascorbic acid, sodium chloride, potassium chloride, magnesium sulfate, etc.). Sometimes solution of glucose of 7,5% to infusions is applied at the idiopathic hypertensia complicated by disturbances of cerebral circulation (in combination with anti-hypertensive means, diuretics, etc.)

Route of administration and doses:

Intravenously rather small volumes (to 50 ml) hypertonic salt solutions of glucose enter struyno. In need of purpose of large volumes (to 250-300 ml a day) they are entered into a vein in the drop way. It is recommended to enter solution of glucose of 7,5% for infusions with a speed up to 60 thaws/min. For more bystry assimilation a glucose organism sometimes at the same time appoint insulin (at the rate of 1 PIECE of insulin to 4-5 g of glucose).

Features of use:

At introduction of large volumes of hypertonic salt solutions of glucose it is necessary to control its level in blood of patients. For fuller and bystry assimilation of a dextrose it is possible to enter п / to 4-5 PIECES of insulin, at the rate of 1 PIECE of insulin on 4-5 g of a dextrose. At a combination with other. The hp needs to control visually compatibility (invisible chemical or therapeutic incompatibility is possible).

Side effects:

Hyperglycemia, fever, hypervolemia, acute left ventricular failure. In an injection site - development of an infection, thrombophlebitis.

Interaction with other medicines:

Solution of glucose of 7,5% for infusions can be applied to dissolution of hydrophilic medicines, and also to appoint in combination with blood-substituting and antishock liquids.

Contraindications:

Hyperglycemia, diabetes mellitus, overhydratation, postoperative disturbances of utilization of glucose; giperosmolyarny coma, hyper lactacidemia.

Overdose:

At overdose of hypertonic salt solutions of glucose development of a hyperglycemia is possible. For its correction use insulin, and also carry out symptomatic therapy.

Storage conditions:

In the dry, protected from light place at a temperature from +5 to +30 °C the Note. Freezing of drug on condition of safety of tightness of a container is not a contraindication to use. Period of validity 2 years.

Issue conditions:

According to the recipe

Packaging:

On 100 ml in polymeric containers.