Ascorbic acid of other 50 mg No. 200 of bank

General characteristics. Structure:

Active components: 0,05 g of ascorbic acid Excipients: sugar, starch syrup, sunflower oil, wax, talc, essence aromatic, dye quinolinic yellow E-104.

Pharmacological properties:

Ascorbic acid actively participates in many redoxreactions, exerts the nonspecific all-stimulating impact on an organism. Increases adaptation abilities of an organism and its resilience to infections; promotes regeneration processes.

Indications to use:

Prevention and treatment hypo - and vitamin C avitaminosis. As supportive application: hemorrhagic diathesis, nasal, uterine, pulmonary bleedings; overdose of anticoagulants; the digestive tract diseases which are followed by vitamin C absorption disturbance; inertly healing wounds. The raised exercise and intellectual stresses, the period of pregnancy and breastfeeding, the recovery period after a serious long illness.

Route of administration and doses:

Drug is accepted inside after food. For prevention: the adult on 0,05-0,1 g (1-2 dragees) a day, to children since 5 years on 0,05 g (1 dragee) a day. For treatment: the adult on 0,05-0,1 g (1-2 dragees) of 3-5 times a day, to children since 5 years on 0,05-0,1 g (1-2 dragees) 2-3 times a day. During pregnancy and breastfeeding on 0,3 g (6 dragees) a day within 10-15 days, further on 0,1 g (2 dragees a day) in day.

Features of use:

In connection with a promoting effect of ascorbic acid on synthesis of corticosteroid hormones, it is necessary to monitor function of adrenal glands and arterial pressure. At prolonged use of high doses oppression of function of the insulyarny device of a pancreas therefore in the course of its treatment it is regularly necessary to control is possible. At patients with the increased content of iron in an organism it is necessary to apply ascorbic acid in the minimum doses. Purpose of ascorbic acid to patients with quickly proliferating and intensively metastasizing tumors can aggravate the course of process. Ascorbic acid as a reducer, can distort results of various laboratory tests (content in blood of glucose, bilirubin, activity of transaminases, LDG).

Side effects:

From the central nervous system (CNS): a headache, feeling of fatigue, at prolonged use of high doses - increase in excitability of TsNS, a sleep disorder.

From the alimentary system: irritation mucous digestive tract, nausea, vomiting, diarrhea, stomach spasms.

From endocrine system: oppression of function of the insulyarny device of a pancreas (hyperglycemia, glucosuria).

From an urinary system: at use in high doses - a giperoksalaturiya and formation of urinary stones from oxalate calcium.

From cardiovascular system: thrombosis, at use in high doses - increase in arterial pressure, development of mikroangiopatiya, a myocardial dystrophy.

Allergic reactions: skin rash, it is rare - an acute anaphylaxis.

Laboratory indicators: thrombocytosis, giperprotrombinemiya, erythropenia, neutrophylic leukocytosis, hypopotassemia. Other: a hypervitaminosis, feeling of heat, at prolonged use of high doses - a delay of sodium (Na+) and liquid, disturbance of exchange of zinc (Zn2+), copper (Cu2+).

Interaction with other medicines:

Increases concentration in blood of benzylpenicillin and tetracyclines; in a dose of 1 g/days increases bioavailability of ethinylestradiol. Improves absorption in intestines of iron preparations (transfers trivalent iron to bivalent); can raise iron excretion at simultaneous use with Deferoxaminum. Acetylsalicylic acid (ASK), oral contraceptives, fresh juice and alkaline drink reduce absorption and assimilation. At simultaneous use with ASK removal with urine of ascorbic acid increases and ASK excretion decreases. ASK reduces absorption of ascorbic acid approximately by 30%. Increases risk of development of a crystalluria at treatment by salicylates and streptocides of short action, slows down removal by kidneys of acids, increases removal of the drugs having alkali reaction (including alkaloids), reduces concentration in blood of oral contraceptives. Increases the general clearance of ethanol which, in turn, reduces concentration of ascorbic acid in an organism. Drugs of a quinolinic row (a ftorkhinolona, etc.), Calcii chloridum, salicylates, glucocorticosteroids at prolonged use exhaust reserves of ascorbic acid. At simultaneous use reduces chronotropic action of an izoprenalin. At prolonged use or use in high doses Disulfiramum ethanol can break interaction. In high doses raises renal excretion of a meksiletin. Barbiturates and Primidonum increase removal of ascorbic acid with urine. Reduces therapeutic action of antipsychotic means (derivatives of a fenotiazin), a canalicular reabsorption of amphetamine and tricyclic antidepressants.

Contraindications:

Hypersensitivity to drug components, thrombophlebitises, tendency to fibrinferments, a diabetes mellitus.

Overdose:

At reception more than 1 g a day heartburn, diarrhea, the complicated urination or coloring of urine in red color, hemolysis are possible (at patients with deficit glyukozo-6-fosfatdegidrogenazy). At emergence of any side effects it is necessary to stop administration of drug and to see a doctor.

Storage conditions:

In the dry, protected from light place at a temperature not above 25 °C. To store in the place, unavailable to children.

Issue conditions:

Without recipe

Packaging:

Dragee on 0,05 g. On 200 pieces in banks from glass melt or in banks from polymeric materials. On 10 pieces in a blister strip packaging. Each can or 5 blister strip packagings together with the instruction on a medical use are placed in a pack. 150 cans are allowed or to place blister strip packagings together with the equal number of instructions in boxes from a cardboard.