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medicalmeds.eu Medicines Vitamins. Ascorbic acid (Vitamin C). Ascorbic kislota-Zdorovye, 10% solution for infection 2 ml No. 10

Ascorbic kislota-Zdorovye, 10% solution for infection 2 ml No. 10

Препарат Аскорбиновая кислота-Здоровье, 10% р-р д/ин 2мл №10. ООО "Фармацевтическая компания "Здоровье" Украина


Producer: LLC Pharmaceutical Company Zdorovye Ukraine

Code of automatic telephone exchange: A11G A01

Release form: Liquid dosage forms. Solution for injections.

Indications to use: Hemorrhagic diathesis. Hemorrhagic stroke. Cirrhosis. Hepatitis. Colitis. Cholecystitis. Psoriasis. Bronchial asthma. Pseudorheumatism.


General characteristics. Structure:

international and chemical names: ascorbic acid; L-ascorbic acid;
main physical and chemical properties: 5% solution - transparent colourless or slightly yellowish solution; 10% solution - transparent yellowish solution;
structure: 1 ml of solution contains ascorbic acid (in terms of 100% substance)
50 mg or 100 mg;
excipients: Natrii hydrocarbonas, sodium metabisulphite, dinatrium эдетат (Trilonum of B), water for injections.




Pharmacological properties:

Pharmacodynamics. The metabolic, antioxidant means regulating oxidation-reduction processes. Regulates hydrogen transport in many biochemical reactions, improves use of glucose in a cycle of tricarboxylic acids, participates in formation of tetrahydrofolic acid and an angenesis, synthesis of steroid hormones, collagen, procollagen. Maintains colloidal state of intercellular substance and normal permeability of capillaries (oppresses hyaluronidase). Activates proteolytic enzymes, participates in exchange of aromatic amino acids, pigments and cholesterol, promotes accumulation in a glycogen liver. Due to activation of respiratory enzymes in a liver strengthens its detoksikatsionny and belkovoobrazovatelny functions, increases synthesis of a prothrombin. Improves bile secretion, recovers externally secretory function of a pancreas and incretory – thyroid. Regulates immunological reactions (activates synthesis of antibodies, C3 component of a complement, interferon), promotes phagocytosis, increases body resistance to infections. Has antiinflammatory and antiallergic effect. Slows down release and accelerates degradation of a histamine, formation of prostaglandins and other mediators of an inflammation and an anaphylaxis oppresses.

Pharmacokinetics. Endogenous concentration in a blood plasma normal makes about 10-20 mkg/ml. Level of depot in an organism makes about 1,5 g. Linkng with proteins of plasma makes about 25%.
Easily gets into leukocytes, thrombocytes, and then – into all fabrics; it is deposited in a back share of a hypophysis, bark of adrenal glands, an eye epithelium, interstitial cells of seminal glands, ovaries, a liver, a brain, a spleen, a pancreas, lungs, kidneys, an intestines wall, heart, muscles, a thyroid gland. It is metabolized preferential in a liver in dezoksiaskorbinovy and further in oxalacetic and diketogulonic acids. The invariable ascorbate and metabolites are removed by kidneys, intestines, and also with then and breast milk


Indications to use:

Treatment hypo - and Page avitaminosis. Hemorrhagic diathesis, capillary toxicosis, hemorrhagic stroke, bleedings; infectious diseases, intoxications, alcoholic and infectious delirium, acute radial illness, posttranfuzionny complications; liver diseases (acute viral hepatitis, chronic hepatitis, cirrhosis), digestive tract (akhiliya, round ulcer, enterita, colitis, helminthoses), cholecystitis, adrenal insufficiency (Addison's disease); hemosiderosis, melanodermas, erythroses, psoriasis, chronic widespread dermatosis; inertly healing wounds, ulcers, fractures of bones; dystrophy, physical and intellectual overworks. As antioxidant – at atherosclerosis, bronchial asthma, diffusion diseases of connecting fabric (a pseudorheumatism, a system lupus erythematosus, a scleroderma). Overdose of anticoagulants; poisoning with streptocides, barbiturates, methyl alcohol, carbon monoxide, anaesthesin, aniline, Disulfiramum, benzene, dichloroethane, potassium permanganate, cyanhydric acid, thallium, phenols, quinine, arsenic, monk's-hood.


Route of administration and doses:

Intramusculary or intravenously. Medical doses for adults make 1 ml of 10% or 1–3 ml of 5% of solution a day. To children appoint 1–2 ml of 5% of solution. Duration of treatment is defined individually with the nature of pathological process and efficiency of therapy.
At poisonings enter 5% of solution to 60 ml. 


Features of use:

With care to use drug for treatment at patients with hypercoagulation, at a diabetes mellitus, renal failures (a giperoksalaturiya, an urolithiasis in the anamnesis, etc.). During pregnancy and feeding by a breast apply in case the potential advantage exceeds possible risk for the fruit/child.
As ascorbic acid increases iron absorption, its use in high doses can be dangerous to patients with hemochromatosis, a thalassemia, a polycythemia, leukemia and sideroblastny anemia.
Patients with the high content of iron in an organism should apply ascorbic acid in the minimum doses.
With care apply to treatment of patients with deficit glyukozo-6-fosfatdegidrogenazy.
It is necessary to apply with care ascorbic acid to treatment at patients with the progressing cancer disease as its use can aggravate the course of a disease.
During prolonged treatment control of function of kidneys, arterial pressure and level of glucose (is necessary especially at purpose of high doses).

Ascorbic acid as a reducer can distort results of various laboratory tests (content in blood of glucose, bilirubin, activity of transaminases, lactate dehydrogenases).


Side effects:

Ascorbic acid, as a rule, is well transferred. At prolonged use in high doses are not excluded: oppression of function of the insulyarny device of a pancreas (hyperglycemia, glucosuria) and synthesis of a glycogen, fibrinferments, giperprotrombinemiya, thrombogenesis, erythrocytopenia, neutrophylic leukocytosis, myocardium dystrophy, damage of the glomerular device of kidneys, allergic reactions (including acute anaphylaxis), increase in arterial pressure. At prolonged use – formation of urinary stones, disturbance of exchange of zinc, copper, increase in excitability of the central nervous system, a sleep disorder, development of mikroangiopatiya.


Interaction with other medicines:

Increases concentration in blood of salicylates (increases risk of a crystalluria), ethinylestradiol, benzylpenicillin and tetracyclines, reduces – oral contraceptives. Reduces anti-coagulative effect of derivatives of coumarin. Increases the general clearance of alcohol. Drugs of a quinolinic row, Calcii chloridum, salicylates, corticosteroids at prolonged use exhaust vitamin C reserves.


Contraindications:

The increased individual sensitivity to ascorbic acid, thromboses, thrombophlebitises.


Overdose:

At prolonged use in high doses allergic reactions, a headache are possible. In case of side effect it is necessary to stop drug use. Symptomatic treatment.


Storage conditions:

To store in the place protected from light at a temperature from 15 °C to 25 °C. To store in the place, unavailable to children.

Period of validity – 2 years


Issue conditions:

According to the recipe


Packaging:

On 2 ml in ampoules; 10 ampoules in a pack.



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