Ascorbic acid of amp. 50 mg; 100 mg/ml No. 10

General characteristics. Structure:

International and chemical names: ascorbic acid; (R) Dihydroxy-ethyl-5-[(S)-1,2] - 3,4 - dihydroxy - 5H - furan - 2 - it; main physical and chemical properties: colourless or with slightly yellowish shade of color transparent liquid. Active ingredient: 1 ml of solution contains ascorbic acid - 50 mg or 100 mg; excipients: Natrii hydrocarbonas, sodium hydrosulphite (Е 222), water for injections.

Pharmacological properties:

Pharmacodynamics. Ascorbic acid - water-soluble vitamin which promotes optimum transition of fabric exchange. Takes active part in redoxreactions, forming system of transfer of a proton of hydrogen with dehydroascorbic acid, shows properties of biooxidizer at the expense of what it provides stability of cellular membranes. Takes part in synthesis of the main substance of connecting fabric of a vascular wall, than interferes with development of hemorrhagic diathesis. At insufficient intake of Ascorbic Acid with food stuffs the odontorrhagia, mucous membranes develops. Takes part in glucose exchange, a cholesterol catabolism, synthesis of steroid hormones. At stressful reactions contents it in an organism, and in epinephral fabric in particular, considerably decreases that confirms participation of Ascorbic Acid in adaptation reactions. It is capable to show antianemic action due to influence on iron exchange. Recovers trivalent iron to bivalent, the last is transported with a blood flow.

Pharmacokinetics. It is soaked up without metabolic cost in a small intestine in the form of degid-roaskorbinovy acid. A concentration maximum in blood in 4 h. Generally collects in bodies with the increased level of exchange processes, in particular in tissue of adrenal glands. In fabrics is both in a stand-at-ease, and in the form of connections. It is brought out of an organism with urine, as in not changed type, and a type of metabolites. Content of Ascorbic Acid in fabrics goes down at alcohol intake and smoking.

Indications to use:

Ascorbic acid is applied for the purpose of treatment in all clinical situations connected with need of additional administration of vitamin C. It is appointed for treatment of a scurvy, at bleedings (uterine, pulmonary, nasal, hepatic, etc.), hemorrhagic diathesis, bleedings as a syndrome of a radial illness, various intoxications and infectious diseases, a nephropathy of pregnant women, Addison's disease, at overdose of anticoagulants, fractures of bones and vyalogranuliruyushchy wounds, various dystrophies, at pregnancy and in the period of a lactation, the increased intellectual tension and the strengthened physical activity.

Route of administration and doses:

Ascorbic acid is appointed intramusculary and intravenously struyno or kapelno.
Intravenously struyno enter within 1 – 3 min. For intravenous drop administration a single dose dissolve 0,9% of solution of sodium of chloride in 50 – 100 ml and enter by slow intravenous infusion with a speed of 30 - 40 thaws into min. Intramusculary enter deeply into a muscle.
Doses establish individually, taking into account character and disease severity.
To adults and children 12 years usually are more senior appoint 50 – 150 mg a day.
To children 12 years are younger appoint intravenously in a daily dose 5 – 7 mg/kg of body weight in the form of 5% of solution (0,5 – 2 ml). The maximum daily dose – 100 mg.
At poisonings the daily dose is raised to 500 mg. The maximum single dose – 200 mg, daily – 1 g.

Features of use:

At use in high doses control of function of kidneys, arterial pressure (stimulation by Ascorbic Acid of formation of corticosteroids), and also functions of a pancreas (oppression of the insulyarny device) is necessary. Use for pregnant women and in the period of a lactation - on doctor's orders. Therapy in high doses should not be carried out at patients with tendency to a recurrent nephrolithiasis. Patients with a renal failure for decrease in risk of a crystalluria need to provide the sufficient use of liquid (1,5 – 2 l a day). Use of high doses of Ascorbic Acid can affect results of some laboratory researches: wrong positive test for availability of sugar in urine and the negative test for existence of the occult blood in Calais, and also understating of results at a research of concentration of a lactate dehydrogenase and aminotransferase in blood serum.
At patients with the increased content of iron in an organism it is necessary to apply Ascorbic Acid in the minimum doses.
The patients who is on a diet with the low content of sodium should not appoint high doses of drug.
Purpose of Ascorbic Acid to patients with quickly proliferating and intensively metastasizing tumors, can strengthen process passing. To the patients taking a chemotherapy course, it is necessary to appoint Ascorbic Acid not earlier than in 1 – 3 day (depending on an elimination half-life of antineoplastic drug) after chemotherapy as there are no clinical data on possible interaction.

Use during pregnancy or feeding by a breast. The minimum daily need for Ascorbic Acid for the II-III trimesters of pregnancy – about 60 mg. Ascorbic acid gets through a placental barrier. It must be kept in mind that the fruit can adapt to high doses of Ascorbic Acid which are accepted by the pregnant woman, and then at the newborn development of an ascorbic disease as reactions of "cancellation" is possible. Thereof during pregnancy it is not necessary to appoint drug in the raised doses, except for cases when the potential advantage for mother exceeds possible risk for a fruit.
The minimum daily need for Ascorbic Acid in the period of a lactation – 80 mg. Mother's diet containing adequate amount of Ascorbic Acid is sufficient for prevention of deficit at the baby. Ascorbic acid is emitted with breast milk. Teoriticheski exists danger to the child if mother accepts high doses of Ascorbic Acid (it is recommended to the nursing mother not to exceed the daily need for Ascorbic Acid). In need of purpose of the raised drug doses in the period of a lactation it is necessary to stop feeding by a breast.
Children. To children 12 years are younger appoint intravenously in a daily dose 5 – 7 mg/kg of body weight in the form of 5% of solution (0,5 – 2 ml). The maximum daily dose – 100 mg.

Side effects:

Ascorbic acid, as a rule, is well transferred, but at prolonged use in high doses negative influence on a pancreas, education in uric ways of calcium oxalate, increase in arterial pressure, increase in excitability TsNS, a sleep disorder, a headache, feeling of fatigue, decrease in permeability of capillaries, nausea, diarrhea, stomach spasms, development of a mikroangiopatiya, allergic reactions, a dermahemia, an acute anaphylaxis, a hypervitaminosis With, disturbance of exchange of zinc and copper is not excluded.

Interaction with other medicines:

Ascorbic acid increases concentration in blood of salicylates (increases risk of a crystalluria), ethinylestradiol, Benzylium-penicillin and tetracyclines, reduces level in blood of oral contraceptives. Increases removal of the drugs having alkali reaction (including alkaloids). In high doses raises renal excretion of a meksiletin.
Tetracyclines and acetylsalicylic acid strengthen removal of Ascorbic Acid with urine.
At co-administration with salicylates and streptocides of short action the risk of formation of uric concrements increases.
High doses of Ascorbic Acid can reduce рН urine owing to what the canalicular reabsorption of amphetamine and the tricyclic antidepressants which are applied at the same time decreases.
Raises iron excretion at the patients accepting Deferoxaminum.
Reduces anticoagulating action of derivatives of coumarin and heparin, efficiency of antibiotics. Increases destruction and the general clearance of alcohol.
Reduces chronotropic action of an izoprenalin and therapeutic action of derivatives of a fe-notiazin.
At simultaneous use with barbiturates, Primidonum excretion of Ascorbic Acid with urine raises.

Contraindications:

Hypersensitivity to Ascorbic Acid, thromboses, thrombophlebitises. At a diabetes mellitus and diseases of a recurrent nephrolithiasis high doses of drug are not appointed.

Overdose:

Acute poisoning with Ascorbic Acid is not described. In case of side effect it is necessary to stop use of drug and to see a doctor.

Storage conditions:

To store in the unavailable to children, protected from light place, at a temperature from +15 °C to +30 °C.

Period of validity - 3 years.

Issue conditions:

According to the recipe

Packaging:

On 2 ml in an ampoule; on 10 ampoules in a pack cardboard.