Teopek

General characteristics. Structure:

Active ingredient: 100 mg, 200 mg and 300 mg of theophylline in 1 tablet.

Excipients: composition polymeric carrier (the polymethacrylic acid and macrogoal (polyethyleneglycol) interpolimerny complex), calcium stearate.

Pharmacological properties:

Pharmacodynamics. Theophylline belongs to phosphodiesterase inhibitors. Increases accumulation in fabrics ts-AMF that reduces sokratitelny activity of smooth muscles. Theophylline expands bronchial tubes, blood vessels (mainly vessels of a brain, skin and kidneys). Reduces pulmonary vascular resistance, lowers pressure in a small circle of blood circulation. Increases a renal blood stream.

Has moderately expressed diuretic effect. Oppresses aggregation of thrombocytes. Has a promoting effect on a respiratory center, increases the frequency and force of cordial reductions. The slowed-down release of active ingredient from a tablet provides achievement of therapeutic level of theophylline in blood in 3-5 hours after Teopek's reception and remains within 10-12 hours. Two times administration of drug allows to receive effective concentration of theophylline in blood within a day. Due to the long effect of drug one of important indications to use is the prevention of the night and phenomena at dawn of a bronchospasm.

Pharmacokinetics. After intake theophylline is completely soaked up (bioavailability of 90%). In blood for 40-60% it is connected with proteins. Gets through gistogematichesky barriers. It Biotrasformirutsya in a liver with formation of inactive metabolites. It is allocated from an organism, generally with kidneys, partially with breast milk.

Indications to use:

Treatment and prevention of a bronkhoobstruktivny syndrome at bronchial asthma, chronic obstructive bronchitis, emphysema of lungs, a dermatorespiratorny syndrome and other diseases of a respiratory organs.

Route of administration and doses:

Teopek apply inside after food, washing down with water. The tablet is not crushed, not chewed and not dissolved in water. The daily dose is divided into 2 receptions with an interval of 12 hours. The optimum dose is selected individually, depending on the nature of a disease, age and the patient's weight.

Drug is appointed by 2 times a day to adults and children 14 years on 300 mg are more senior; children are from 7 to 12 years old - on 200 mg, from 3 to 7 years - on 100 mg.

In the first day treatment is begun with a half of a daily dose in 2 receptions. In the absence of side reactions pass to a full daily dose.

Duration of use of drug depends on features of a course of a disease and the rendered therapeutic effect. On average the course of treatment can last from 2 weeks to 2 months.

Features of use:

At a serious illness of cardiovascular system, a liver, viral infections, and also at patients of advanced age the dose of drug should be reduced.

Efficiency of effect of theophylline can decrease at smokers.

As broncholitic action of Teopek develops gradually in 3-6 hours after reception, drug is not appointed for stopping of medical emergencies.

To be careful at the use of large numbers of kofeinsoderzhashchy products or drinks during treatment.

Side effects:

From a nervous system: dizziness, headache, bessonknitsa, excitement, uneasiness, irritability, tremor.

From cardiovascular system: Heartbeat, tachycardia (including at a fruit at reception of the pregnant woman in the III trimester), arrhythmias, a snikzheniye of arterial pressure, a cardialgia, increase in frequency of attacks of stenocardia.

From the alimentary system: a gastralgia, nausea, vomiting, a gastroesophageal reflux, heartburn, an aggravation of a peptic ulcer, diarrhea, at long reception - a loss of appetite.

Allergic reactions: skin rash, itch, fever.

Others: a stethalgia, a tachypnea, feeling of inflows to the person, an albumiknuriya, a hamaturia, a hypoglycemia, strengthening of a diuresis increased potootdelekny. Side effects decrease at a drug dose decline.

Interaction with other medicines:

Theophylline is not applied together with other derivatives of xanthine. In a combination with phenobarbital, dipheninum, rifampicin, an isoniazid, carbamazepine, Sulfinpyrazonum, Phenytoinum decrease in efficiency of theophylline is observed that increase in the applied drug doses can demand.

At simultaneous use with antibiotics of group of makkrolid, lincomycin, Allopyrinolum, Cimetidinum, izoprenaliny, beta adrenoblockers, oral contraceptives, enoksatsiny and at vaccination against flu intensity of action can increase that can demand a theophylline dose decline.

Theophylline increases probability of development of side effects of glucocorticosteroids, mineralokor-tikosteroid (hypernatremia), the means exciting the central nervous system (increases a neurotoxicity).

Drug suppresses terapevtikchesky effects of lithium carbonate and beta adrenoblockers. Theophylline exponentiates effect of diuretics due to increase in glomerular filtering and reduction of a canalicular reabsorption.

With care theophylline is appointed along with anticoagulants. Antidiarrheal drugs and enterosorbents reduce theophylline absorption.

Contraindications:

Hypersensitivity (including to other derivatives of xanthine - to caffeine, a pentoksifillin, theobromine), an acute myocardial infarction, heavy arterial hyper - or hypotension, widespread atherosclerosis of vessels, serious violations of a cordial rhythm (heavy tachyarrhythmias, premature ventricular contraction), hyperfunction of a thyroid gland, a peptic ulcer of a stomach and duodenum in aggravation stages, gastritis with a hyperoxemia, bleeding from digestive tract, epilepsy, the increased convulsive activity, a hemorrhagic stroke, an eye retinal apoplexy, pregnancy, children's age up to 3 years.

With care it is necessary to apply at heavy stenocardia, heart failure, a hypertrophic cardiomyopathy, the expressed abnormal liver functions and kidneys, a peptic ulcer of a stomach and a duodenum (in the anamnesis), bleeding from digestive tract in the recent anamnesis, a long hyperthermia, a gastroesophageal reflux, a prostatauxe.

Overdose:

Symptoms: a loss of appetite, a gastralgia, diarrhea, nausea, vomiting (including with blood), gastrointestinal bleeding, a tachypnea, a dermahemia of the person, tachycardia, ventricular arrhythmias, sleeplessness, motive excitement, uneasiness, a photophobia, a tremor, spasms. At a serious poisoning epileptoidny attacks, a hypoxia, a metabolic acidosis, a hyperglycemia, a hypopotassemia, a lowering of arterial pressure, confusion of consciousness, a renal failure with a myoglobinuria can develop.

Treatment: drug withdrawal, a gastric lavage, purpose of absorbent carbon, HP laxatives, an enteroclysis a combination of polyethyleneglycol and electrolytes, an artificial diuresis, hemosorption, a plazmosorbtion, a hemodialysis (efficiency is not high, peritoneal dialysis is not effective), symptomatic therapy (including Metoclopramidum and ондансетрон – at vomiting). When developing spasms to maintain passability of respiratory tracts and to carry out an oxygenotherapy. For stopping of an attack - in/in diazepam, 0.1-0.3 mg/kg (but no more than 10 mg). At severe nausea and vomiting - Metoclopramidum or ондансетрон (in/in).

Storage conditions:

List B. In the dry place protected from light at a temperature not above 25 °C. To store in the place, unavailable to children. A period of validity - 5 years. Not to use after a period of validity.

Issue conditions:

According to the recipe

Packaging:

Tablets of the prolonged action of 100, 200 or 300 mg. On 10 tablets in a blister strip packaging. 50 tablets on 100 and 200 mg or 40 tablets on 300 mg in banks plastic. On 5 blister strip packagings or each can with the application instruction in a pack from a cardboard. 50 cans plastic, intended for a hospital, pack together with application instructions in number of 50 pieces into a box from a cardboard.