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Biofestal

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General characteristics. Structure:

Active agents: Pancreatinum - 192-210 mg, gemitsellyulaza-50 mg, extract of bull bile-25 of mg.

Excipients: structure of a kernel - sodium chloride, lactose, starch soluble, microcrystallic cellulose, talc, magnesium stearate, silicon dioxide colloid; structure of a cover - cellulose acetate-phthalate, diethyl phthalate, a gidroksipropilmetiltsellyuloza, titanium dioxide, talc.




Pharmacological properties:

Compensates insufficiency of vneshnesekretorny function of a pancreas, has proteolytic, amylolytic and lipolytic effect. The enzymes (a lipase, alpha amylase, trypsin, chymotrypsin) which are a part of Pancreatinum promote the proteolysis to amino acids, fats to glycerin and fatty acids, starch to dextrins and monosaccharides. Improves a functional condition of digestive tract, normalizes digestion processes. Pancreatic enzymes are released from a dosage form in the alkaline environment of a small intestine since are protected from action of a gastric juice of a cover.


Indications to use:

Replacement therapy at vneshnesekretorny insufficiency of a pancreas: chronic pancreatitis, a pancreatectomy, a state after radiation, dyspepsia, Remkheld's syndrome (a gastrocardial syndrome), a mucoviscidosis, a meteorism, diarrhea of noninfectious genesis. Disturbance of digestion of food (a state after a resection of a stomach and a small intestine; for improvement of digestion of food at persons with normal function of digestive tract in case of errors in food (the use of greasy food, a large number of food, irregular food) and at disturbances of chewing function, a slow-moving way of life, a long immobilization. Preparation to radiological and to ultrasound examination of abdominal organs.


Route of administration and doses:

Inside. Drug is accepted in time or after food, without chewing and washing down with not alkaline liquid (water, fruit juice). The dose is defined individually. Duration of treatment can vary of several days (at disturbance of process of digestion owing to errors in a diet) up to several months or years (in need of continuous replacement therapy).


Features of use:

At a mucoviscidosis use of Pancreatinum in high doses owing to increase in risk of development of strictures (a fibrous colonopathy) is not recommended. The dose has to be adequate to amount of enzymes which is necessary for absorption of fats taking into account quality and amount of the consumed food.


Side effects:

Allergic reactions. Seldom - diarrhea, a lock, a sensation of discomfort in a stomach, nausea (relationship of cause and effect of development of these reactions is not established with action of Pancreatinum since the specified phenomena belong to symptoms of vneshnesekretorny insufficiency of a pancreas). At prolonged use in high doses are possible development of a hyper uricosuria, hyperuricemia. At a mucoviscidosis in case of exceeding of a necessary dose of Pancreatinum development of strictures (a fibrous colonopathy) in ileocecal department of the ascending colon is possible. At use of Pancreatinum in high doses at children emergence of perianal irritation and irritation of a mucous membrane of an oral cavity is possible.


Interaction with other medicines:

At use of Pancreatinum decrease in absorption of iron and folic acid is possible. Simultaneous use of the antiacid means containing calcium calcium a carbonate and/or magnesium hydroxide can lead to decrease in efficiency of Pancreatinum.


Contraindications:

Hypersensitivity to drug components, acute pancreatitis, an exacerbation of chronic pancreatitis, children's age up to 6 years. Use at pregnancy and a lactation. Safety of use of Pancreatinum at pregnancy is studied insufficiently. Use is possible in cases when the expected advantage for mother exceeds potential risk for a fruit. In the period of a lactation use of Pancreatinum is not contraindicated.


Overdose:

Symptoms: hyper uricosuria, hyperuricemia. Children have a lock.

Treatment: drug withdrawal, symptomatic therapy.


Storage conditions:

At a temperature not above +25 °C, in dry, protected from light, the place, unavailable to children.


Issue conditions:

Without recipe


Packaging:

Dragee. On 10 dragees in planimetric bezjyacheykovy packaging or on 10 dragees in a blister strip packaging. 1, 2, 3, 5, 10 planimetric strip or bezjyacheykovy packagings together with the application instruction place in a pack from a cardboard.



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