Ambroxol

General characteristics. Structure:

Active ingredient: 30 mg of Ambroxol of a hydrochloride (in terms of 100% contents).

Excipients: starch corn, cellulose microcrystallic, aerosil, magnesium stearate, lactose.

The broncholitic drug stimulating mukotsiliarny activity also has expectorant effect.

Pharmacological properties:

Pharmacodynamics. Expectorant mucolytic means. Has the expressed sekretolitichesky effect, stimulating serous cells of glands of a mucous membrane of bronchial tubes, increasing the maintenance of a mucous component of a phlegm. At the same time Clark's cells are stimulated and the hydrolyzing enzymes are activated that also leads to decrease in viscosity of a phlegm. Ambroxol has sekretomotorny property, stimulating work of a ciliary epithelium of bronchial tubes, thereby, providing otkhozhdeny phlegms, recovering drainage function of small bronchial tubes and bronchioles.

Indications to use:

Drug is used at the respiratory diseases which are followed by formation of the hardly separated viscous secret: acute and chronic bronchitis of a different etiology, pneumonia, bronchiectasias, atelectases of lungs, bronchial asthma, tracheitises, laryngitis, sinusitis and rhinitises.

Drug can be used at a syndrome of insufficient breath ("a shock lung") for prevention and treatment of complications after lung operations, at care of a tracheostoma, before and after a bronkhoskopiya, at a mucoviscidosis.

Route of administration and doses:

Adults and children are more senior than 12 years accept drug inside on 1 tablet (30 mg) 2 times a day, and if necessary – 3 times (in time or after food), washing down with a small amount of liquid.

If necessary for strengthening of therapeutic effect it is possible to appoint 60 mg (2 tablets) of 2 times/days.

At a severe disease the dose of drug is not reduced throughout the entire period of treatment. The course of treatment makes from 4 to 14 days.

Features of use:

It is not recommended to take along with Ambroxol drugs antibechic action (for example, containing codeine) because of difficulty of removal of a phlegm from bronchial tubes at reduction of cough.

One tablet of Ambroxol contains 147 mg of lactose of monohydrate that makes 588 mg of lactose of monohydrate in most recommended daily dose (120 mg). This drug should not be accepted to the patients having rare inborn intolerance of fructose, deficit of lactase of Lapp or bad digestion of glucose galactose.

It was reported about several cases of strong injury of skin, including Stephens-Johnson's syndrome and a toxic epidermal necrolysis associated with reception of such mucolytic means as Ambroxol a hydrochloride. These cases can be explained, as a rule, with severity of associated diseases or a concomitant use of other drugs. Besides, at an early stage of a syndrome of Stephens-Johnson and a toxic epidermal necrolysis patients can have signs of the beginning of the nonspecific disease reminding flu: fervescence, all body pain, rhinitis, cough and pharyngalgia. Emergence of these signs can bring in an unnecessary symptomatic treatment anti-cold drugs.

Therefore, at emergence of injuries of skin or mucous it is necessary to see immediately a doctor, and treatment by Ambroxol should be stopped as a precautionary measure.

At a renal failure Ambroxol can be accepted only after consultation with the doctor.

Influence on ability to driving of motor transport and to control of mechanisms. It is not known of cases of influence of drug on ability to drive the car and mechanisms. The corresponding researches were not conducted.

Wide clinical experience of use did not reveal undesirable effects of treatment by drug at pregnancy. Nevertheless, it is necessary to follow the general rules of prescription of medicines at pregnancy. Ambroxol is not recommended during the I trimester of pregnancy. Ambroxol gets into breast milk. Though an adverse effect on the child, Ambroxol is not supposed it is not recommended for use during breastfeeding.

Side effects:

From the alimentary system: seldom – nausea, vomiting, diarrhea, abdominal pains.

Allergic reactions: skin rash, small tortoiseshell, Quincke's disease.

Others: seldom - weakness, a headache.

Interaction with other medicines:

Therapeutic the Ambroxol combination with theophylline is reasonable, use of drug with cardiac glycosides, diuretics and antibiotics is possible.

Ambroxol the hydrochloride increases efficiency of ampicillin and amoxicillin, increasing their concentration in blood.

Contraindications:

— peptic ulcer of a stomach and duodenum;

— convulsive syndrome of various etiology;

— I trimester of pregnancy;

— hypersensitivity to drug;

— children's age up to 12 years.

Overdose:

It is not described. At accidental overdoses it was reported that observed symptoms correspond to possible side effects of Ambroxol at reception in the recommended doses. Nausea, vomiting, diarrhea, dyspepsia are possible.

Treatment: artificial vomiting, a gastric lavage in the first 1-2 h after administration of drug; reception of fat-containing products, symptomatic therapy.

Storage conditions:

In the place protected from moisture and light at a temperature not above 25 °C. To store in the places protected from children. Period of storage 3 years.

Issue conditions:

Without recipe

Packaging:

On 10 tablets in blister strip packagings. After 2 or 5 blister strip packagings in a cardboard pack together with the application instruction.