Dimedrol

General characteristics. Structure:

Active agent: дифенгидрамин 50 mg.

Pharmacological properties:

Blocker histamine H1 receptors. Has antiallergic activity, renders mestnoanesteziruyushchy, spasmolytic and moderate ganglioblokiruyushchy action. At intake causes sedative and somnolent effect, has moderate antiemetic effect, and also has the central cholinolytic activity.
At external use has antiallergic effect.

Pharmacokinetics. It is quickly absorbed from a GIT. Bioavailability makes 50%. Cmax is reached in 20-40 min. (in the greatest concentration is defined in lungs, a spleen, kidneys, a liver, a brain and muscles). Linkng with proteins of plasma – 98-99%. Gets through GEB. It is metabolized mainly in a liver, partially - in lungs and kidneys. T1/2 - 4-10 h During the day is completely removed by kidneys in the form of the metabolites conjugated with glucuronic acid. Essential quantities are removed with milk and can cause sedation in children of chest age (the paradoxical reaction which is characterized by hyperexcitability can be observed).

Indications to use:

Allergic reactions (urticaria, hay fever, Quincke's disease), allergic conjunctivitis, vasculomotor rhinitis, a hemorrhagic vasculitis, a serum disease, a pruritic dermatosis, sleep disorders (monotherapy or in a combination with hypnotic drugs), a chorea, sea and aeroembolism, vomiting of pregnant women, Menyer's syndrome, premedication.

Route of administration and doses:

The adult inside - on 30-50 mg of 1-3 times/days. A course of treatment - 10-15 days. As a hypnagogue - on 50 mg before going to bed. In oil - in doses of 50-250 mg; in/in kapelno - 20-50 mg.
At intake single doses for children aged till 1 year - 2-5 mg; from 2 to 5 years - 5-15 mg; from 6 to 12 years - 15-30 mg.
Outwardly apply 1-2 times/days.

Features of use:

With care apply дифенгидрамин at pregnancy and in the period of a lactation.
During treatment it is not necessary to be affected by sunlight, it is necessary to avoid alcohol intake.

Influence on ability to driving of motor transport and to control of mechanisms
With care apply at the patients who are engaged in potentially dangerous types of activity requiring special attention and bystry psychomotor reactions.

Side effects:

Perhaps: short-term numbness of a mucous membrane of an oral cavity, drowsiness, general weakness, reduction in the rate of psychomotor reaction; at children perhaps paradoxical development of sleeplessness, irritability and euphoria.

Seldom: dizziness, a headache, dryness in a mouth, nausea, a photosensitization, accommodation paresis, a lack of coordination of movements, a tremor.

Interaction with other medicines:

At simultaneous use strengthens effect of ethanol and drugs, the oppressing TsNS.
At simultaneous use MAO inhibitors increase anticholinergic activity of a difengidramin.
Antagonistic interaction is noted at joint appointment with psychostimulants.
Reduces efficiency of Apomorphinum as vomitive at treatment of poisoning. Strengthens anticholinergic effects of drugs with holinoblokiruyushchy activity.

Contraindications:

Closed-angle glaucoma, prostatauxe, the stenosing stomach ulcer and a duodenum, a bladder neck stenosis, bronchial asthma, epilepsy, hypersensitivity to a difengidramin.

Use at pregnancy and feeding by a breast
At pregnancy and in the period of a lactation (breastfeeding) дифенгидрамин apply with care, according to strict indications, in cases when the expected therapeutic effect for mother exceeds potential risk for a fruit or the baby.

Overdose:

There are no data.

Storage conditions:

List B.: In the place protected from light.

Issue conditions:

According to the recipe

Packaging:

Tablets of 50 mg: 10 or 20 pieces.