To Grippofl for cold and flu powder, No. 10 (raspberry) (in a pack)

General characteristics. Structure:

Active ingredients: paracetamol of 0,325 g, Phenylephrinum hydrochloride of 0,010 g; pheniramine maleate of 0,020 g, ascorbic acid of 0,050 g. Excipients: sugar, citric acid, sodium citrate a dihydrate, Cranberry or Malines fragrance, either "Strawberry", or "Currant", calcium the phosphate 3-replaced titanium dioxide, dye quinolinic yellow E-104, acid red 2C for the pharmaceutical purposes.

Pharmacological properties:

The combined drug. Paracetamol – non-narcotic analgesic, influences the centers of pain and thermal control. Has analgeziruyushchy and febrifugal effect. Reduces head and muscular pains, the fever phenomena, alleviates pharyngalgias. Pheniramine – a blocker of H1-histamine receptors, antiallergenic means, reduces a rhinorrhea and dacryagogue, eliminates the spastic phenomena. Fenilefrin – адреномиметик with moderate vasoconstrictive action, reduces a congestion of a nose and facilitates breath through a nose. Ascorbic acid – participates in regulation of oxidation-reduction processes, carbohydrate metabolism, coagulability of blood, increases resistance of an organism to infections, reduces vascular permeability. Improves portability of paracetamol and extends its action.

Indications to use:

Infectious and inflammatory diseases (SARS, flu) which are followed by high temperature, a fever and fever, a headache, cold, a nose congestion, sneezing and muscle pains.

Route of administration and doses:

To dissolve contents of one package in 1 glass of boiled hot water; to use hot. It is possible to add sugar to taste. It is possible to accept a repeated dose every 4 hour, but no more than 3 doses of drug within 24 hours. Reception duration as an antipyretic – no more than 3 days.

Features of use:

Without instructions of the doctor pregnant women and nursing mothers, and also the patients who are receiving medical treatment using other medicines should not use drug. In particular monoaminooxidase inhibitors. Drug is not appointed to children aged up to 12 years. At administration of drug it is not recommended to drive the car or other mechanisms, to take alcoholic drinks, means, the oppressing central nervous system (hypnagogues, tranquilizers, etc.)

Side effects:

Allergic reactions (skin rash, itch, small tortoiseshell, Quincke's disease), nausea, pains in epigastriums, anemia, thrombocytopenia, an agranulocytosis. Hyperexcitability, dizziness, increase in arterial pressure, heartbeat, backfilling disturbance. Increase in intraocular pressure, dryness in a mouth, an ischuria. At prolonged use in high doses perhaps hepatotoxic and nephrotoxic action (renal colic, a glucosuria, insterstitsialny nephrite, a papillary necrosis), hemolitic anemia, aplastic anemia, a methemoglobinemia, a pancytopenia.

Interaction with other medicines:

Strengthens effects of inhibitors of a monoaminooxidase, sedative medicines, ethanol. Ethanol strengthens sedative effect of antihistaminic medicines. Antidepressants, protivoparkinsonichesky and antipsychotic medicines, fenotiazinovy derivatives increase risk of development of an ischuria, dryness in a mouth, locks. Glucocorticosteroids increase risk of development of increase in intraocular pressure. Paracetamol reduces efficiency of uricosuric medicines and increases efficiency of indirect anticoagulants. Tricyclic antidepressants strengthen sympathomimetic action, co-administration of a halothane increases risk of development of ventricular arrhythmia. Reduces hypotensive action of a guanetidin who in turn increases alpha адреностимулирующую activity of Phenylephrinum.

Contraindications:

Arterial hypertension, diabetes mellitus, closed-angle glaucoma, serious illness of a liver, kidneys, hearts, a thyroid gland, lungs (including bronchial asthma), a bladder, a peptic ulcer of a stomach and duodenum, a disease of a pancreas, difficulty of an urination at adenoma of a prostate, a disease of system of blood, deficit of enzyme glyukozo-6-fosfatdegidrogenazy, hypersensitivity to separate components of drug. Pregnancy and period of a lactation. To children aged up to 12 years.

Overdose:

Symptoms (are caused by paracetamol): pallor of integuments, loss of appetite, nausea, vomiting; гепатонекроз. Toxic action at adults perhaps after reception over 10-15 g of paracetamol: increase in activity of "hepatic" transaminases, increase in a prothrombin time (through 12-48ch after reception); the developed clinical picture of damage of a liver is shown in 1-6 days. Seldom liver failure develops immediately and can be complicated by a renal failure (a tubular necrosis). Treatment: introduction of donators of SH – groups and predecessors of synthesis of glutathione-methionine in 8-9 h after overdose and N – Acetylcysteinum in 12 hours. Need for holding additional therapeutic actions is defined depending on concentration of paracetamol in blood, and also from time which passed after its reception.

Storage conditions:

In the dry, protected from light place at a temperature not above +30 °C. To store in the place, unavailable to children.

Issue conditions:

Without recipe

Packaging:

Powder of 13,0 g in a package from the material combined. On 10 packages in packs from a cardboard or 100 packages in boxes from a cardboard.