Ascorbic acid with glucose

General characteristics. Structure:

Active agents: ascorbic acid – 100 mg, glucose – 684 mg.

Excipients: sodium of starch glikolit 8,0 mg, calcium stearate of 8,0 mg.

Pharmacological properties:

Pharmacokinetics. Ascorbic acid is well soaked up preferential in duodenal and a jejunum. In 30 min. after introduction the content of ascorbic acid in blood considerably increases, begins intensive capture its fabrics due to initial transformation its dehydroascorbic acid which has ability to get through cellular membranes without metabolic cost and to be recovered quickly in a cell. Intracellularly ascorbic acid is defined in three forms — ascorbic, dehydroascorbic acids and an askorbigen (the combined ascorbic acid). Distribution between bodies uneven: there is a lot of it in hemadens, especially in adrenal glands, it is less - in a brain, kidneys, a liver, in cordial and skeletal muscles. Ascorbic acid is partially metabolized and emitted to 90% with kidneys in the form of oxalate, partially — in a free form.

Glucose is easily soaked up, the main ways of metabolism is glycolysis and aerobic oxidation with formation of carbon dioxide and water with release of ATP and other makroergichesky connections.

The pharmacodynamics Ascorbic acid which part the diyenolny group is has the expressed recovery properties. Its participation in oxidation-reduction processes, regulation of exchange of carbohydrates, blood coagulation process, biosynthesis of steroid hormones, an angenesis, synthesis of collagen and procollagen, normalization of permeability of capillaries is connected with it. The lack of food of ascorbic acid which is not synthesized in an organism promotes development of avitaminosis or S. Glyukoz's hypovitaminosis takes part in carbohydrate and power exchanges, improves the detoksikatsionny potential of an organism, optimizing thus a number of its functions.

Indications to use:

- hypo - and vitamin C avitaminosis;

- bleedings (uterine, pulmonary, nasal, etc.);

- hemorrhagic diathesis;

- various intoxications and infectious diseases;

- overdose of anticoagulants;

- inertly healing wounds, ulcers, fractures of bones;

- dystrophies;

- exercise and intellectual stresses;

- period of pregnancy and lactation.

Route of administration and doses:

Inside after food. For the purpose of prevention appoint the adult of 1/2-1 tablet in days; during pregnancy, in a puerperal period and at the low content of vitamin C in milk of nursing mothers appoint 3 tablets a day for 10-15 days then preventively on 1 tablet a day throughout the entire period of a lactation. Medical doses for adults make 1/2–1 tablets of 3-5 times a day.

To children from 5 years appoint with the preventive purpose ¼ tablets a day, with the medical purpose — 1/2–1 tablets 2-3 times a day.

Terms of treatment depend on character and the course of a disease.

Features of use:

As drug is widely used as supportive application, the first signs of improvement of a state depend on character and the course of a disease and efficiency of treatment. At use in high doses control of functions of kidneys and arterial pressure (stimulation by ascorbic acid of formation of corticosteroids), and also functions of a pancreas (oppression of the insulyarny device) is necessary.

With extra care appoint to patients with an urolithiasis, it is not recommended it is long to apply high doses. Use of high doses of drug can affect results of some laboratory analyses (glucose level in urine, a research a calla on the occult blood).

This dosage form of drug is not applied at children up to 5 years.

Does not influence ability to manage the vehicle or potentially dangerous mechanisms.

Side effects:

- hyperglycemia;

- glucosuria, oppression of synthesis of a glycogen;

- arterial hypertension;

- heartburn, diarrhea;

- weakness;

- skin rash;

- tranzitorny decrease рН urine;

- oppression of function of the insulyarny device of a pancreas;

- oppression of function of kidneys;

- allergic reactions;

- hypervitaminosis;

- formation of urinary, tsistinovy and oxalic stones in kidneys.

Interaction with other medicines:

Drug increases absorption of penicillin, iron, weakens effect of heparin, indirect anticoagulants, increases risk of a kristallouriya at treatment by salicylates.

At simultaneous use with estrogen - hormone level in blood serum increases. With the oral contraceptives containing estrogen the contraceptive effect decreases. It is not recommended to apply along with antibiotics of a tetracycline row (except for doxycycline), the interval between their reception has to make not less than 2 hours. Ascorbic acid with glucose increases concentration of salicylates, benzylpenicillin and tetracyclines in blood serum, reduces efficiency of oral contraceptives.

Contraindications:

- hypersensitivity to drug components;

- the increased coagulability of blood;

- thrombophlebitises, tendency to fibrinferments;

- diabetes mellitus;

- deficit glyukozo-6-fosfatdegidrogenazy.

Overdose:

Acute poisoning is not described. At prolonged use even in therapeutic doses causes considerable changes in an organism - permeability of capillaries and gistogematichesky barriers sharply decreases, function of an organ of sight decreases, prothrombin level in blood increases, reduction of quantity of erythrocytes and a considerable neutrophylic leukocytosis is noted, the myocardium trophicity is broken; in a number of bodies activity of fabric dehydrogenases decreases.

Symptoms: nausea, skin rash, itch, oppression of function of the insulyarny device of a pancreas, renal failure, increase in the ABP.

Treatment: symptomatic. It is necessary to stop administration of drug, to wash out a stomach, to give to the patient alkaline drink, absorbent carbon or other adsorbents and to see a doctor.

Storage conditions:

To store in the dry, protected from light place, at a temperature from 2 to 30 ºС.

To store in the place, unavailable to children!

Issue conditions:

Without recipe

Packaging:

Tablets on 100 mg in a blister strip packaging of 10 pieces.