Bofen

General characteristics. Structure:

Active ingredient: ibuprofen; structure: 5 ml of suspension contain 100 mg of an ibuprofen; excipients: Natrium benzoicum (Е 211), glycerin, maltit liquid, saccharin of sodium, sodium citrate, citric acid monohydrate, sodium chloride, polysorbate 80, gum xanthane, fragrance food orange, the water purified.

Pharmacological properties:

Drug has febrifugal, antiinflammatory and analgeziruyushchy effect. The mechanism of action consists in inhibition of synthesis of prostaglandins – mediators of temperature reaction, an inflammation and pain.

After intake the ibuprofen is absorbed in a digestive tract and begins to have effect through an insignificant period. Effect of drug lasts till 8 o'clock.

Indications to use:

•  Fever of various origin (including after immunization);
• pain of weak or moderate intensity (including head, a dentagra, ear and throat pain, at a teething, after an odontectomy, at stretchings, neuralgia and pain of an inflammatory origin).

Route of administration and doses:

Before each use suspension should be shaken up.

The dose depends on age and the body weight of the child. A single dose – 5-10 mg/kg of body weight.

The maximum daily dose should not exceed 30 mg/kg of body weight.

At fever and pain apply:

to children from 3 to 6 months – on 2,5 ml (50 mg) each 8 hours, but no more than 7,5 ml (150 mg) a day;

from 6 to 12 months – on 2,5 ml (50 mg) each 6-8 hours, but no more than 10 ml (200 mg) a day;  

from 1 year to 3 years – on 5 ml (100 mg) each 8 hours, but no more than 15 ml (300 mg) a day;

from 4 to 6 years – on 7,5 ml (150 mg) 3 times a day (450 mg);

from 7 to 9 years – on 10 ml (200 mg) 3 times a day (600 mg);

from 10 to 12 years – on 15 ml (300 mg) 3 times a day (900 mg).

At fever after immunization apply:

to children at the age of 3-6 months – 2,5 ml, if necessary – 2,5 more ml in 6 hours, but no more than 5 ml within 24 hours.

Duration of treatment depends on the course of a disease and usually makes 3 days.

Features of use:

Consultation of the doctor is recommended to the patients having in the anamnesis bronchial asthma, a peptic ulcer, gastritis, ulcer colitis, bleedings of digestive tract, a disease of kidneys or a liver at simultaneous use with other anesthetizing drugs, indirect anticoagulants (the means reducing coagulability of blood), drugs for a lowering of arterial pressure, diuretic, lithium drugs, a methotrexate.

It is not necessary to exceed the recommended doses.

Drug is used to children aged from 3 months up to 12 years. To children under 7 years drug is used only under observation of the doctor.

 
Use during pregnancy or feeding by a breast. Drug is used only to children up to 12 years.


Ability to influence speed of response at control of motor transport or work with other mechanisms. Drug is used only to children up to 12 years.

 
Children. Drug is used to children aged from 3 months (with body weight not less than 5 kg) up to 12 years in the doses specified in the section "Route of Administration and Doses".

Side effects:

From digestive tract: nausea, vomiting, a sensation of discomfort or pain in epigastriums, laxative effect, emergence of erosive cankers, bleedings is possible.
Allergic reactions: skin rashes, itch, urticaria, exacerbation of bronchial asthma, bronchospasm, anaphylaxis, nonspecific allergic reactions.

From the central nervous system: headache, dizziness.

From bodies of a hemopoiesis: anemia, thrombocytopenia, agranulocytosis, leukopenia.

From an urinary system: renal failure.

Interaction with other medicines:

Extra care at a concomitant use of drug is necessary Bofen with acetylsalicylic acid and other non-steroidal anti-inflammatory drugs.

Simultaneous use of Bofen with anticoagulants (the means reducing coagulability of blood) can lead to strengthening of their action.

Bofen increases concentration of digoxin, Phenytoinum, methotrexate, lithium in a blood plasma at simultaneous use with these drugs.

Bofen's use along with diuretic and anti-hypertensive means reduces their efficiency.

Drug strengthens side effects of mineralokortikosteroid and glucocorticosteroids.

Contraindications:

Hypersensitivity to an ibuprofen or to other components of drug;

• hypersensitivity to acetylsalicylic acid or to other non-steroidal anti-inflammatory drugs;
• digestive tract canker;
• exacerbation of bronchial asthma, urticaria, rhinitis owing to reception of acetylsalicylic acid (salicylates) or other non-steroidal anti-inflammatory drugs;
• blood diseases (leukopenia, hemophilia, hypocoagulation), bleeding;
• renal and/or liver failure;
• decrease in hearing;
• deficit of a glyukozo-6-phosphate-dehydrogenase;
• children's age up to 3 months.

Overdose:

Symptoms: abdominal pain, nausea, vomiting, headache, dizziness, sonitus, loss of consciousness, lowering of arterial pressure, metabolic acidosis, bradycardia, tachycardia, acute renal failure.

Treatment: a gastric lavage (only within 1 hour after reception), absorbent carbon, alkaline drink, an artificial diuresis, symptomatic therapy.

Storage conditions:

It is not necessary to use drug after the termination of the period of validity specified on packaging. To store in the place, unavailable to children, at a temperature not over 25 to a °s.posla of opening of a bottle a period of validity of drug of 30 days at a temperature not above 25 °C.   

Period of validity - 2 years.

Issue conditions:

Without recipe

Packaging:

On 100 ml in a polymeric can, 1 bank in a pack together with the spoon dosing. On 100 ml in a glass or polymeric bottle, 1 bottle in a pack together with the spoon dosing.