Ibuprofen

General characteristics. Structure:

Active ingredient: 200 mg of an ibuprofen in 1 tablet.

Excipients; magnesium stearate, potato starch, sugar, wheat flour, povidone, gelatin, acid red 2C E-122, dextrin, beeswax.

Drug has analgeziruyushchy, antiinflammatory, febrifugal effect.

Pharmacological properties:

Pharmacodynamics. Inhibits cyclooxygenase and blocks biosynthesis of prostaglandins. Analgeziruyushchy action is caused by decrease in intensity of an inflammation, reduction of development and weakening of an algogennost of bradikinin; antiinflammatory — intervention in different links of a pathogeny of an inflammation (the hyperpermeability of vessels is normalized, microcirculation improves, the liberation of a histamine, bradikinin, etc. inflammation mediators decreases, formation of ATP is slowed down that causes decrease in power supply of inflammatory process); febrifugal — reduction of excitability of the heatregulating centers of a diencephalon. Expressiveness of antipyretic effect depends on the initial body temperature and a dose. Reversibly inhibits aggregation of thrombocytes.

At a pseudorheumatism influences preferential on exudative and partly on proliferative components of inflammatory reaction, has the bystry and expressed anesthetizing effect, reduces puffiness, morning constraint and restriction of mobility in joints.

At primary dysmenorrhea reduces the intrauterine pressure and frequency of uterine reductions.

Pharmacokinetics. About 80% of the dose accepted inside are absorbed (quickly). The maximum concentration in a blood plasma is reached in 60 min. Linkng with proteins of plasma — 99%. Slowly gets into a joint cavity, but is late in synovial fabric, creating in it big concentration, than in plasma.

Is exposed to biotransformation with formation of three main metabolites. Products of metabolic disintegration are brought out of an organism quickly and completely with urine. The elimination half-life makes — 2 — 2,5 h.

Indications to use:

The pseudorheumatism deforming the osteoarthrosis ankylosing a spondylitis, a joint syndrome at an exacerbation of gout, psoriartichesky arthritis; neuralgia, mialgiya, tendovaginitis, bursitis, radiculitis, traumatic inflammation of soft tissues and musculoskeletal system.

As supportive application at infectious and inflammatory diseases of ENT organs, an adnexitis, primary dysmenorrhea, head and a dentagra.

Route of administration and doses:

To adults and children 12 years drug are more senior appoint in an initial dose 0,2 g 3 — 4 times a day. For achievement of bystry therapeutic effect the dose can be increased to 0,4 g 3 times a day. On reaching medical effect the daily dose is reduced to 0,6 — 0,8 g.

The first day dose is accepted to food, washing down with enough water for the purpose of bystry absorption of drug. Other doses accept for day after food (gradual absorption).

The maximum single dose — 0,4 g, the maximum daily dose — 1,2 g.

Features of use:

The use of alcoholic beverages during treatment is not recommended.

Side effects:

Heartburn, nausea, vomiting, meteorism, dizziness, headache, excitement, sleeplessness, skin allergic reactions, toxic amblyopia, renal failures with a delay of sodium and water are possible. Digestive tract erosive cankers are seldom observed.

At the expressed by-effects it is necessary to stop administration of drug and to see a doctor.

Interaction with other medicines:

Reduces anti-hypertensive activity of APF inhibitors, natriuretic — furosemide and hypothiazid. Can increase toxicity of a methotrexate and drugs of lithium.

At combined use with anticoagulants of coumarinic type and alcohol increases risk of hemorrhagic complications, the combined use with the tableted glucocorticoids increases danger of gastrointestinal bleeding.

Increases concentration of digoxin in plasma. Caffeine strengthens analgeziruyushchy effect of an ibuprofen.

Contraindications:

Hypersensitivity (including to acetylsalicylic acid and other NPVS); the bronchial asthma provoked by reception of acetylsalicylic acid; diseases of an optic nerve; a peptic ulcer of a stomach and/or intestines in an aggravation phase, thrombocytopenia, hemorrhagic diathesis, nonspecific ulcer colitis, portal hypertensia, scotoma, an amblyopia, the last trimester of pregnancy, a lactation (it is necessary to suspend breastfeeding).

Overdose:

Symptoms: abdominal pains, nausea, vomiting, block, drowsiness, depression, headache, sonitus, metabolic acidosis, coma, acute renal failure, hypotension, bradycardia, tachycardia, fibrillation of auricles, apnoea.

Treatment: a gastric lavage (within 1 hour after reception), absorbent carbon (for absorption reduction), alkaline drink, an artificial diuresis and symptomatic therapy (correction of KShchR, the ABP, gastrointestinal bleeding).

Storage conditions:

In the place protected from moisture and light at a temperature not above 25 °C. To store in the place, unavailable to children. Period of validity 3 years. Not to use after the period of validity specified on packaging.

Issue conditions:

Without recipe

Packaging:

Tablets, coated, 200 mg in a blister strip packaging No. 10х5.