Компливит® D3 Calcium
Producer: JSC Pharmstandart Russia
Code of automatic telephone exchange: [A12AX]
Release form: Firm dosage forms. Tablets.
General characteristics. Structure:
Active components:
|
Calcium (in the form of carbonate calcium) |
- 500 mg - 1,250 g |
|
Kolekaltsiferol (D3 vitamin) in the form of the granulate containing: колекальциферол, butyl hydroxytoluene, sucrose, gelatin, sodium aluminosilicate, triglycerides of an average chain, the starch modified water. |
0,005 mg (200 ME) |
Excipients: milk sugar (lactose), polyvinylpirrolidone low-molecular (povidone), potato starch, вивасол (croscarmellose sodium), citric acid, aspartame, magnesium stearate, fragrance orange (powder).
Description . Chewable tablets with a rough porous surface of a round biconvex form from color, white to white with a creamy shade, with impregnations of gray color with a slight fruit smell.
Pharmacological properties:
The combined drug which effect is caused by the components which are its part. Regulates exchange of calcium and phosphates, reduces a resorption and increases density of a bone tissue, compensates for the deficiency of calcium and D3 vitamin of an organism, strengthens absorption of calcium in intestines and a reabsorption of phosphates in kidneys, promotes a mineralization of bones.
Calcium – participates in formation of a bone tissue, a blood coagulation, in maintenance of stability of cordial activity, in implementation of processes of transfer of nervous impulses.
D3 vitamin (колекальциферол) – promotes absorption of calcium in intestines, to formation and a mineralization of a bone tissue and tissue of teeth.
Use of calcium and D3 vitamin interferes with increase in production of parathyroid hormone which is a stimulator of the raised bone resorption.
Pharmacokinetics. D3 vitamin is soaked up in a small intestine. Calcium is soaked up in the ionized form in proximal department of a small intestine by means of active D-vitamin of the dependent transport mechanism.
Indications to use:
Prevention and complex therapy of osteoporosis (menopauzny, senile, "steroid", idiopathic).
Prevention and treatment of deficit of calcium and/or D3 vitamin.
Route of administration and doses:
Inside, chew or swallow entirely, it is preferential during food.
Adult: at treatment of osteoporosis – on 1 tablet 2-3 times a day, for prevention of osteoporosis – on 1 tablet 2 times a day.
At deficit of calcium and vitamin D:
- To adults and children 12 years – on 1 tablet 1-2 times a day are more senior.
- To children from 5 to 12 years - on 1-2 tablets a day.
- To children from 3rd to 5 years – a dosage according to recommendations of the doctor.
Features of use:
Компливит® D3 Calcium contains aspartame which in an organism is transformed to phenylalanine therefore the patients suffering from a fenilketonuriya should not accept drug.
During treatment it is necessary to control constantly removal of calcium with urine and concentration of calcium and creatine in a blood plasma (in case of the calciuria exceeding 7,5 mmol/days (300 mg/days) it is necessary to reduce a dose or to stop reception).
At elderly people the need for calcium makes 1500 mg/days, in D3 vitamin – 0,5-1 thousand. ME/days.
In order to avoid overdose it is necessary to consider additional intake of D3 vitamin from other sources.
Use during pregnancy and breastfeeding
During pregnancy the daily dose should not exceed 1500 mg of calcium and 600 ME D3 vitamins.
Vitamin D and its metabolites can get into breast milk.
Overdose
Side effects:
Allergic reactions. Dispeptic frustration from digestive tract (locks, a meteorism, nausea, a stomach ache, diarrhea). A hypercalcemia and a hypercalcuria (the increased content of calcium in blood and urine).
Interaction with other medicines:
Activity of D3 vitamin can decrease at its simultaneous use with Phenytoinum or barbiturates.
At simultaneous treatment by cardiac glycosides control of an ECG and clinical state since drugs of calcium can exponentiate therapeutic and toxic effects of cardiac glycosides is necessary.
Drugs of calcium and D3 vitamin can increase absorption of tetracyclines from digestive tract. Therefore time interval between administrations of drugs has to be not less than 3 hours.
For prevention of decrease in absorption of drugs of bisfosfonat or sodium fluoride it is recommended to accept Komplivit® D3 Calcium not earlier than in two hours after their reception.
Glucocorticosteroids reduce absorbability of calcium therefore treatment by glucocorticosteroids can demand increase in a dose of the drug Komplivit® D3 Calcium.
Simultaneous treatment by drugs of Colestyraminum or purgatives on the basis of mineral or vegetable oil can reduce D3 vitamin absorption.
At simultaneous use of diuretics of a thiazide row the risk of emergence of a hypercalcemia as they increase a canalicular reabsorption of calcium increases. Furosemide and other "loopback" diuretics, on the contrary, increase calcium removal by kidneys.
Contraindications:
Hypersensitivity to drug components, a hypercalcemia, a hypercalcuria, calcic нефроуролитиаз, a hypervitaminosis D, the decalcifying tumors (a myeloma, bone metastasises, a sarcoidosis), the osteoporosis caused by an immobilization, a fenilketonuriya (contains aspartame), a pulmonary tuberculosis (an active form), a chronic renal failure, children's age up to 3 years.
With care:
Pregnancy, lactation period.
Overdose:
Symptoms: thirst, polyuria, loss of appetite, nausea, vomiting, lock, dizziness, weakness, headache, unconscious states, coma; at prolonged use: calcification of vessels and fabrics. Laboratory indicators at overdose: a hypercalcuria, a hypercalcemia (calcium in plasma about 2,6 mmol).
Treatment: a regidratation, "loopback" diuretics, glucocorticosteroid drugs, a calcitonin, bisfosfonata, a diet with calcium restriction, carrying out a hemodialysis.
In case of detection of symptoms of overdose to see a doctor.
Storage conditions:
To store in dry, protected from light, the place, unavailable to children, at a temperature not higher than 25 ° C.
Period of validity - 2 years. Not to use after a period of validity.
Issue conditions:
Without recipe
Packaging:
Chewable tablets [orange].
On 30, 60, 90, 100 or 120 tablets in banks polymeric. Banks cork the cover screwed. Each can fitted by a cap protective thermoshrinkable together with the instruction on a medical use is placed in a pack from a cardboard.
Or banks on 60, 90, 100 or 120 tablets with the multipage label, the containing full text of the instruction on a medical use fitted by a cap protective thermoshrinkable place in a transport container.
