Ascorbic acid

General characteristics. Structure:

Active ingredient: 1 g of ascorbic acid.

The drug containing ascorbic acid.

Pharmacological properties:

Pharmacodynamics. Ascorbic acid participates in oxidation-reduction processes, takes part in formation of an active form of folic acid, protects hemoglobin and oxyhemoglobin, iron of tsitokhrom P450.

Ascorbic acid plays an important role in biosynthesis of collagen, serotonin, hormones of adrenal glands, a kannitina, promotes release of iron from the connected state with transferrin and to its absorption from intestines.

Vitamin C is extracellular and intracellular antioxidant, actively connects free radicals. Antioxidant effect of ascorbic acid amplifies at combined use of tocopherol and Retinolum. Vitamin C promotes increase in body resistance to an adverse effect of the environment, improves overall health, increases efficiency of action of various therapeutic actions, has radio tire-tread properties, reduces hemorrhagic manifestations of a radial illness and stimulates a krovoobrazovaniye.

Pharmacokinetics. Ascorbic acid is soaked up throughout digestive tract, is preferential in a small intestine: in 30-60 min. A vitamin C elimination half-life - 4 - 7 hours after its reception. Surplus is removed with urine in the form of acid ascorbic and its metabolites: treonovy, xylonic, lyxonic and oxalic acids. With increase in a dose up to 200 mg and more absorbability of ascorbic acid decreases. Absorption can be also broken at intestinal diskineziya, enterita and an akhiliya.

Indications to use:

Prevention and treatment hypo - and vitamin C avitaminosis Ensuring the increased need of an organism for vitamin C during pregnancy, feedings by a breast at high exercise and intellectual stresses, overfatigue, stressful states, during recovery after a long serious illness. It is applied in complex therapy at hemorrhagic diathesis, bleedings, including at overdose of anticoagulants, vyalozazhivayushchy wounds and fractures of bones.

Route of administration and doses:

Drug is accepted inside after food in the form of solution. 1 package (0,5 g) is dissolved in 0,5 l of boiled water or 1 package (1,0 g) in 1 l.

In the preventive purposes appoint adult 100 ml (100 mg) a day, to children 6 years - 50 ml (50 mg) a day are more senior.

Medical doses for adults make on 100 ml 2 times a day (200 mg), for children over 6 years on 50 ml 2 times a day (100 mg).

Features of use:

Simultaneous use of drug with alkaline drink (mineral waters) reduces vitamin C absorption.

Ascorbic acid can influence results of various laboratory researches, for example, when determining content in blood of glucose, bilirubin, activity of transaminases, lactatedihydrogenases.

Side effects:

Allergic reactions are possible. At long use in high doses there can be a hyperglycemia, a glucosuria, arterial hypertension. Contraindications. Hypersensitivity to drug. It is not necessary to appoint high doses of drug the patient with the increased coagulability of blood, thrombophlebitises, tendency to fibrinferments. And also at the diabetes mellitus and states which are followed by the increased content of sugar in blood.

Interaction with other medicines:

Ascorbic acid reduces toxicity of sulfanamide drugs, reduces effect of heparin of indirect anticoagulants, increases penicillin absorption, strengthens effect of side effect of salicylates (risk of emergence of a crystalluria).

Use of oral contraceptives reduces vitamin C level in an organism. At simultaneous use of low doses of vitamin C and B1, B2 vitamins and in, mutual strengthening of therapeutic action is defined. Vitamin P (routines) considerably improves digestion of vitamin C.

It is necessary to avoid simultaneous use of ascorbic acid with therapeutic doses of B12, PP, B6 vitamins, with an Euphyllinum, iron preparations and copper.

Overdose:

The overdose promotes the raised thrombogenesis. Long, uncontrolled use of drug can lead to oppression of the insulyarny device of a pancreas, causes considerable change in a metabolism. It needs to be considered, appointing ascorbic acid a sick diabetes mellitus.

Storage conditions:

In dry, protected from light, the place, unavailable to children, at a temperature not above 25 °C. Period of validity 2 years. Not to use drug after the termination of the period of validity specified on packaging.

Issue conditions:

Without recipe

Packaging:

On 1 g of powder in the thermostuck together aluminum packages, on 20 bags in a cardboard pack together with the application instruction.