Antikataral

General characteristics. Structure:

Main physical and chemical properties: white homogeneous powder without lumps, after dissolution in water has an orange flavor;
Active agent: 1 bag contains paracetamol 650 mg, Phenylephrinum of a hydrochloride of 10 mg, chlorphenaminum of a maleate of 4 mg; excipients: aerosil 200, anhydrous citric acid, sodium saccharinate, sucrose, sodium cyclomate anhydrous, fragrance orange.

Pharmacological properties:

Pharmacodynamics. The combined drug which effect is caused by effects of the components entering it. Paracetamol — an analgetic antipyretic — has the expressed analgesic, febrifugal effect. The specified effects of paracetamol are connected with its influence on the center of thermal control in a hypothalamus, ability to inhibit synthesis of prostaglandins in TsNS. Fenilefrina a hydrochloride — a sympathomimetic — has vasoconstrictive effect, reduces puffiness of a mucous membrane of a nose and adnexal bosoms. Chlorphenaminum a maleate — a blocker histamine _{H1 receptors} — have antiallergic effect, reduce expressiveness of local exudative processes, eliminate dacryagogue, allocations from a nose, an itch in eyes and in a nose, possess moderate broncholitic action.

Pharmacokinetics. It was not studied.

Indications to use:

Symptomatic treatment of flu and the acute respiratory infections which are followed by fervescence, muscle and joints pain, a headache, a nose congestion, cold, dacryagogue.

Route of administration and doses:

To adults and children 12 years are more senior appoint on one bag each 6-8 hours, but no more than 6 bags a day. Before reception contents of one bag need to be dissolved in half of glass of warm water. More than 5 days are not recommended to accept drug.

Features of use:

It is not necessary to exceed the recommended drug doses. At emergence of side effects use of drug should be stopped. During administration of drug it is not recommended to accept other paratsetamolsoderzhashchy drugs, sympathomimetics (Phenylephrinum, pseudoephedrine, etc.), barbiturates, tranquilizers, and also to take alcohol. With care appoint Antikataral to patients with diseases of cardiovascular system, a liver, kidneys, a thyroid gland, to the persons suffering from a diabetes mellitus, a chronic obstructive disease of lungs, bronchial asthma, glaucoma, a prostatauxe with disturbance of an urination, anemia. Active ingredient of drug, Phenylephrinum, is capable to yield positive analytical take of a drug test. Drug can be used not earlier than in 15 days after the end of treatment by MAO inhibitors, tricyclic antidepressants and metildopy.

Pregnancy and feeding by a breast. Pregnancy and feeding by a breast are contraindications to Antikataral's use. In need of purpose of drug in the period of a lactation feeding by a breast is recommended to be stopped for all term of use of drug.
Influence on ability to manage vehicles or to work with difficult mechanisms. During administration of drug it is necessary to refrain from control of vehicles and from work with potentially dangerous mechanisms.

Use for children up to 18 years. In the presence of indications Antikataral it is possible to apply at children from 12 years.

Side effects:

Can be noted: drowsiness, a sleep disorder, a headache, hypererethism, euphoria, a lack of coordination of movements, pain in epigastric area, nausea, anorexia, jaundice, a skin itch, rash, a Quincke's edema, hemolitic anemia, thrombocytopenia, an agranulocytosis, a leukopenia, feeling of dryness in a mouth, difficulty of an urination, accommodation disturbance, increase in intraocular pressure, tachycardia, a sleep disorder, increase in arterial pressure.

Interaction with other medicines:

Simultaneous use of Antikataral with monoamine oxidase inhibitors (MAO), tricyclic antidepressants, metildopy can lead to the expressed arterial hypertension, tachycardia, a hyperthermia, dysfunction of the main vitals that can lead to death. Drug strengthens effects of sedative and antiepileptic drugs, ethanol and etanolsoderzhashy drugs. At simultaneous use of Antikataral with antihypertensives efficiency of the last can decrease. At simultaneous use with some hypnotic drugs, barbiturates, antiepileptic drugs, rifampicin, ethanol non-toxic doses of paracetamol can cause injury of a liver. At simultaneous use of paracetamol with azidothymidine development of a neutropenia is possible. At simultaneous use paracetamol strengthens a chloramphenicol hepatotoxic. Drug exponentiates effect of indirect anticoagulants. Simultaneous use with ß adrenoblockers can cause arterial hypertension and bradycardia.

Contraindications:

Hypersensitivity to drug components, a serious illness of a liver or kidneys, uncontrollable arterial hypertension, the expressed atherosclerosis, pregnancy, the feeding period a breast, children's age up to 12 years.

Overdose:

Perhaps hepatotoxic and nephrotoxic action, disturbances of a cordial rhythm, excitement, dizziness, sleep disorder, nausea, anorexia, stomach ache, drowsiness, weakness, lack of coordination of movements, increase or lowering of arterial pressure, is very rare — thrombocytopenia, hemolitic anemia. The overdose of paracetamol can cause injury of a liver, jaundice, гепатонекроз. In case of overdose drug is cancelled, carry out a symptomatic treatment. It is necessary to wash out a stomach and to enter 30-50 g of absorbent carbon that considerably reduces paracetamol absorption. Antidotes of paracetamol are Acetylcysteinum and methionine.

Storage conditions:

To store at a temperature not above +25 °C. To store in the place, unavailable to children. A period of validity — 3 years. The deadline of the validity is specified on packaging after the words "Use to …"

Issue conditions:

According to the recipe

Packaging:

On 10 bags in a cardboard pack.