Rederm

General characteristics. Structure:

Active ingredients: 0,05 g of betamethasone of Dipropionas in terms of betamethasone, 3 g of salicylic acid.

Excipients: liquid paraffin (liquid paraffin), vaseline (vaseline white, paraffin white soft).

The drug for topical administration rendering antiinflammatory, antiallergic, antipruritic, keratolytic actions.

Pharmacological properties:

Pharmacodynamics. The combined drug for external use which action is caused by the components which are its part; drug renders antiinflammatory, antiallergic, antipruritic, keratolytic actions. Betamethasone slows down release of mediators of an inflammation, prevents regional accumulation of neutrophils, reduces inflammatory exudate and products of cytokines, reduces migration of macrophages, leading to reduction of processes of infiltration and granulation.

Thanks to availability of salicylic acid softens skin, eliminates horn stratifications and promotes deeper penetration of betamethasone.

Indications to use:

Rederm is shown for use at therapy of the subacute and chronic dermatosis which is followed by a hyperkeratosis and a peeling: psoriasis, disgidrotichesky dermatitis, eczema, neurodermatitis, red flat deprive, an ichthyosis and ichthyotic damages of skin, atopic dermatitis, diffusion neurodermatitis; simple and allergic dermatitis; small tortoiseshell, multiformny exudative erythema; chronic deprive idle time (limited neurodermatitis). The dermatosis which is not giving in to treatment by other glucocorticosteroids (especially red warty deprive), a skin dyshydrosis.

Route of administration and doses:

Outwardly. Apply on affected areas from calculation: a column of ointment 0,5 cm long on the site of skin about 7 cm x 7 cm in size, slightly rubbing, a thin layer 2 times a day. Other frequency of use can be established by the doctor, proceeding from disease severity. In mild cases ointment is enough to be applied, as a rule, once a day; at more severe defeats more frequent use can be necessary.

If necessary apply occlusive bandages which are changed by each 24 h.

Duration of treatment depends on efficiency and portability of therapy and makes 2-4 weeks.

If clinical improvement does not occur, it is necessary to specify the diagnosis.

Features of use:

Use at pregnancy and in the period of a lactation. Safety of use of local glucocorticosteroids for pregnant women is not established. Appointment of this group of medicines during pregnancy is justified only if the potential advantage for mother surpasses potential risk for a fruit. During pregnancy drugs of this group should not be used in high doses or a long time.

It is not established whether topical administration of glucocorticosteroids the reason of emergence them in mother's milk therefore it is necessary to resolve an issue of the breastfeeding termination can become.

Use in pediatrics. To children from 2 years drug is appointed only according to strict indications and under medical control as development of the system side effects connected with betamethasone is possible. Duration of treatment has to be the shortest. At use of drug on extensive surfaces and/or under an occlusive bandage function suppression гипоталамо - pituitary and adrenal system and development of symptoms of a hypercorticoidism is possible, decrease in excretion of a growth hormone, increase in intracranial pressure can be observed.

To avoid hit of drug in eyes, it is impossible to apply on skin near eyes and on mucous membranes. Drug is not intended for use in ophthalmology.

At long treatment, when putting drug on the extensive surfaces of skin, when using occlusive bandages system absorption of glucocorticosteroids is possible.

Prolonged use on face skin – possibly development of dermatitis as a rozatse, perioral dermatitis, an atrophy of skin and an acne is not recommended; to avoid use in anogenitalny area.

Ointment is most suitable for treatment of patients with dry and brittle skin.

If the signs of hypersensitivity or irritation of skin connected using drug are noted it is necessary to stop treatment and to pick up to the patient adequate therapy.

At long use of drug its cancellation should be carried out gradually.

Side effects:

Burning, irritation, dryness, hypopigmentation, skin itch, folliculitis, hypertrichosis, dermatitis, aknepodobny rashes.

At use of occlusive bandages – maceration of skin, a striya, a skin atrophy, secondary infection, a heat rash.

At prolonged use – a skin atrophy, a local hirsutism, teleangiectasias, a purpura, hypopigmentation, a hypertrichosis.

When drawing on big surfaces – system manifestations of side effects of glucocorticosteroids (a growth inhibition, an Icenco-Cushing syndrome, increase in intracranial pressure after the end of treatment, a hyperglycemia, a glucosuria, a hypopotassemia, increase in arterial pressure) or salicylates (pallor, increased fatigue, drowsiness, a hyperventilation against the background of a tachypnea, nausea, vomiting, a hearing disorder, confusion of consciousness).

Interaction with other medicines:

Interaction of drug with other medicines is not revealed.

Contraindications:

Children's age up to 2 years, the lactation period, hypersensitivity, open wounds, bacterial, viral and fungus skin diseases (a pyoderma, syphilis, a tuberculosis cutis, chicken pox, herpes, an actinomycosis, a zymonematosis, a sporotrichosis); postvaccinal skin reactions, perioral dermatitis, a rozatse, trophic ulcers against the background of chronic venous insufficiency, a skin tumor (a carcinoma cutaneum, a nevus, an atheroma, an epithelioma, a melanoma, a hemangioma, a xanthoma, sarcoma).

With care. A liver failure, children's age (2 years are more senior), long therapy, especially with use of occlusive bandages.

Overdose:

The acute overdose is improbable, however, at excessive or prolonged use of drug the chronic overdose which is followed by hypercorticoidism signs is possible: hyperglycemia, glucosuria, reversible oppression of function of bark of adrenal glands, manifestation of a syndrome of Cushing.

Treatment. The corresponding symptomatic treatment is shown. In case of chronic toxic action gradual drug withdrawal is recommended.

Storage conditions:

In the place, unavailable to children, at a temperature not above 25 °C. Period of validity 2 years. Not to use after a period of validity.

Issue conditions:

Without recipe

Packaging:

Ointment for external use. On 5 g, 15 g or 30 g in tubas aluminum. Each tuba together with the application instruction is placed in a pack from a cardboard.