Antigrippin-orvi

General characteristics. Structure:

Active agent:

the capsule A - ascorbic acid of 300 mg, acetylsalicylic acid of 250 mg, rutoside of 20 mg;
the capsule B - дифенгидрамин 20 mg, calcium a gluconate of 100 mg, metamizol sodium of 250 mg.

Pharmacological properties:

The combined drug. Action is caused by the components which are a part of drug.
Acetylsalicylic acid possesses anesthetic, febrifugal and antiinflammatory action, slows down aggregation of thrombocytes.
Ascorbic acid plays an important role in regulation of oxidation-reduction processes, carbohydrate metabolism, coagulability of blood, an angenesis, promotes increase in body resistance.
Metamizole sodium (analginum) possesses anesthetic, febrifugal and weak antiinflammatory action which mechanism is connected with oppression of synthesis of prostaglandins.
Difengidramin (Dimedrol) renders antiallergenic, antiedematous, mestnoanesteziruyushchy (reduces permeability of vessels, eliminates puffiness and a hyperemia of a mucous membrane of a nose, irritation in a throat, allergic reactions from upper respiratory tracts) action.
Calcium the gluconate is the regulator of exchange of calcium and phosphorus, has antiallergenic effect (the mechanism is not clear), reduces permeability of vessels. For treatment of allergic diseases or complications its combined use with antihistaminic drugs is recommended.

Indications to use:

— the symptomatic treatment at adults and children is more senior than 15 years of catarrhal diseases, flu, a SARS.

Route of administration and doses:

Inside, after food, washing down with water, 2-3 times a day within 3-5 days before disappearance of symptoms of a disease.
To adults and children 15 years are more senior appoint 2 capsules to reception: 1 yellow capsule (from the blister A) and 1 white capsule (from the blister B).
In the absence of improvement of health administration of drug it is necessary to stop and see a doctor.

Features of use:

Drug is not appointed as an antipyretic - to children up to 15 years with the acute respiratory diseases caused by viral infections because of danger of development of a syndrome Reja (encephalopathy and acute fatty dystrophy of a liver with acute development of a liver failure).
At long use of drug control of peripheral blood and a functional condition of a liver is necessary. As acetylsalicylic acid has anti-aggregation effect, the patient if surgical intervention is necessary to it, has to warn the doctor about administration of drug in advance. Acetylsalicylic acid in low doses reduces removal of uric acid. It can provoke a gout attack in some cases.
During treatment it is necessary to refuse the use of alkogolsoderzhashchy drinks (increase in risk of gastrointestinal bleeding).
Acetylsalicylic acid has teratogenic influence: at use in the I trimester of pregnancy leads to a malformation - splitting of the upper sky; in the III trimester - braking of patrimonial activity (inhibition of synthesis of prostaglandins), closing of an arterial channel at a fruit that causes a hyperplasia of pulmonary vessels and hypertensia in vessels of a small circle of blood circulation. Acetylsalicylic acid is emitted with breast milk that increases risk of developing of bleedings at the child owing to dysfunction of thrombocytes.
In connection with a promoting effect of ascorbic acid on synthesis of corticosteroid hormones, it is necessary to monitor function of kidneys and arterial pressure. Purpose of ascorbic acid to patients with quickly proliferating and intensively metastasizing tumors can aggravate the course of process. Ascorbic acid as a reducer, can distort results of various laboratory tests (content in blood of glucose, bilirubin, activity of "hepatic" transaminases, LDG).
At the patients having bronchial asthma and pollinoses development of hypersensitivity reactions is possible.
During use of drug it is necessary to abstain from the active types of activity connected with need of concentration of attention and the increased speed of psychomotor reactions.

Side effects:

Anorexia, nausea, vomiting, gastralgia, diarrhea, GIT erosive cankers, gastrointestinal bleedings, liver and/or renal failure, increase in arterial pressure, tachycardia. Allergic reactions: skin rash, Quincke's edema, bronchospasm. At long reception (more than 7 days) - dizziness, a headache, vision disorders, a sonitus, a leukopenia, thrombocytopenia, an agranulocytosis; at tendency to a bronchospasm provoking of an attack is possible; decrease in aggregation of thrombocytes, hypocoagulation, a hemorrhagic syndrome (nasal bleeding, bleeding of gums, purple, etc.), damage of kidneys with a papillary necrosis; deafness; an acute anaphylaxis, Stephens-Johnson's syndrome, a toxic epidermal necrolysis (Lyell's disease), a syndrome Reja at children (a hyper pyrexia, a metabolic acidosis, disturbances from a nervous system and mentality, vomiting, abnormal liver functions). The renal failure, oliguria, anury, protenuriya, intersticial nephrite, coloring of urine in red color due to allocation of a metabolite is possible.

It is necessary to report about all side (unusual) effects including which are not stated above to the attending physician and to stop administration of drug.

Interaction with other medicines:

In need of joint reception with other medicines - previously to consult with the doctor.

Strengthens effect of heparin, peroral anticoagulants, Reserpinum, steroid hormones of hypoglycemic means. Reduces efficiency of Spironolactonum, furosemide, hypotensive drugs, the antigouty means promoting removal of uric acid.

Strengthens side effects of glucocorticosteroids, derivative sulphonylurea, a methotrexate, non-narcotic analgesics and non-steroidal anti-inflammatory drugs.

It is necessary to avoid a drug combination with barbiturates, antiepileptic means, a zidovudine, rifampicin and alkogolsoderzhashchy drinks (the risk of hepatotoxic effect increases).

Ascorbic acid improves absorption in intestines of iron preparations. Tricyclic antidepressants, contraceptives for intake and Allopyrinolum break metabolism of metamizol in a liver and increase its toxicity. Metamizol strengthens effects of alkogolsoderzhashchy drinks.

Radiopaque substances, colloid blood substitutes and penicillin should not be applied during treatment by metamizol.

Simultaneous use of metamizol with cyclosporine reduces the level of the last in blood. Thiamazolum and sarcolysine increase risk of development of a leukopenia.

Sedatives and tranquilizers strengthen the anesthetizing effect of metamizol.

Contraindications:

— erosive cankers (in an aggravation phase) a GIT;
— gastrointestinal bleeding;
— the increased tendency to bleedings;
— the bronchial asthma, diseases which are followed by a bronchospasm, "aspirinovy asthma";
— hemopoiesis oppression (agranulocytosis, neutropenia, leukopenia);
— heavy abnormal liver functions or kidneys;
— the hereditary hemolitic anemia connected with deficit glyukozo-6-fosfatdegidrogenazy;
— hemorrhagic diathesis (hemophilia, angiohemophilia, telangiectasia, prothrombinopenia, thrombocytopenia, Werlhof's disease);
— the stratified aortic aneurysm;
— portal hypertensia;
— a hypercalcemia (concentration of calcium ions should not exceed 12 mg of % or 6 ¼Ø¬ó/l);
— hypercalcuria;
— nephrolithiasis (calcic);
— sarcoidosis;
— intoxication cardiac glycosides (risk of developing of arrhythmia);
— deficit of vitamin K;
— deficit glyukozo-6-fosfatdegidrogenazy.;
— pregnancy and period of breastfeeding;
— children's age up to 15 years;
— hypersensitivity to drug components.

With care - a hyperuricemia, an uratny nephrolithiasis, gout, a peptic ulcer of a stomach and/or duodenum (in the anamnesis), dekompensirovanny heart failure.

Use at pregnancy and feeding by a breast
It is contraindicated during pregnancy and in the period of a lactation:
Acetylsalicylic acid has teratogenic influence: at use in the I trimester of pregnancy leads to a malformation - splitting of the upper sky; in the III trimester - braking of patrimonial activity (inhibition of synthesis of prostaglandins), closing of an arterial channel at a fruit that causes a hyperplasia of pulmonary vessels and hypertensia in vessels of a small circle of blood circulation. Acetylsalicylic acid is emitted with breast milk that increases risk of developing of bleedings at the child owing to dysfunction of thrombocytes.

Use at abnormal liver functions
It is contraindicated at heavy abnormal liver functions.

Use at renal failures
It is contraindicated at heavy renal failures. With care - an uratny nephrolithiasis.

Use for children
It is contraindicated to children up to 15 years.

Overdose:

Symptoms: nausea, vomiting, stomach aches, perspiration, pallor of integuments, tachycardia. At slight intoxications - a ring in ears; heavy intoxication - drowsiness, a collapse, spasms, a bronchospasm, the complicated breath, an anury, bleedings, the progressing paralysis of breath and the dissociation of oxidizing phosphorylation causing respiratory acidosis. At suspicion of poisoning it is necessary to ask for medical assistance immediately.

Treatment: to cause vomiting, to make a gastric lavage, to accept salt laxatives, absorbent carbon. In the conditions of medical institution - carrying out an artificial diuresis, hemodialysis, at development of a convulsive syndrome - intravenous administration of diazepam and barbiturates.

Storage conditions:

In dry, protected from light, the place, unavailable to children, at a temperature of 25 °C.

Issue conditions:

According to the recipe

Packaging:

Kombinir. unitary enterprise. (set of capsules of two types), including:; капс. And yellow color: 10 pieces; капс. B of white color: 10 pieces.