Laslonvita

General characteristics. Structure:

Active agents:  

isoniazid                                of 75 mg                                
Pyrazinamidum                          of 400 mg                              
rifampicin                           of 150 mg                              
Ethambutolum hydrochloride         of 275 mg                                
pyridoxine hydrochloride         of 20 mg

Pharmacological properties:

The combined antituberculous remedy.
The isoniazid has bactericidal effect on actively sharing Mycobacterium tuberculosis cells, synthesis of the mikoliyevy acids which are a component of a cell wall oppresses, possesses moderate action on slowly and fast-growing atypical mycobacteria. For mycobacteria of tuberculosis of MPK makes 0.025-0.05 mg/l.
Rifampicin has bactericidal effect on inside - and vnekletochno the located microorganisms, oppresses a DNA-dependent RNA polymerase of microorganisms. For MPK tuberculosis mycobacteria - 2 mg/l.
Pyrazinamidum has bactericidal activity, previously turning into an active form - pirazinovy acid. A target of Pyrazinamidum is the gene of a sintetaza of the I mikobakterialny fatty acid participating in biosynthesis of mikoliyevy acid. Affects intracellularly located mycobacteria, well gets into tuberculous focuses. In the MPK acid environment makes 20 mg/l.
Ethambutolum - bacteriostatic drug, is effective concerning typical and atypical mycobacteria of tuberculosis. Suppresses synthesis of a cell wall, blocking inclusion in it of mikoliyevy acids. MPK makes 0.78-2 mg/l.
Pyridoxine - vitamin means; participates in a metabolism. It is necessary for normal functioning of TsNS and a peripheral nervous system. Antitubercular medicines can reduce concentration of a pyridoxine, in this regard the daily need for vitamin increases to 60 mg.

Indications to use:

— the tuberculosis (for the first time revealed any forms).

Route of administration and doses:

Inside, in the morning, on an empty stomach in 30-40 min. prior to food. Dosing is carried out on rifampicin - 10 mg/kg of body weight, but no more 5th tablet Course of treatment - 2-4 months.
At body weight more than 80 kg the isoniazid is in addition appointed in the evening (the general daily dose of an isoniazid - 10 mg/kg).
If necessary it is possible to combine with administration of streptomycin in oil in a dose 15 mg/kg of 1 times/days.

Features of use:

There are no data.

Side effects:

Isoniazid
- From TsNS and a peripheral nervous system: a headache, dizziness, it is rare - fatigue, weakness, irritability, euphoria, sleeplessness, paresthesias, numbness of extremities, peripheral neuropathy, an optic neuritis, a polyneuritis, psychoses, emotional lability, a depression, increase of attacks at patients with epilepsy.
- From cardiovascular system: heartbeat, stenocardia, increase in the ABP.
From the alimentary system: nausea, vomiting, gastralgia, toxic hepatitis.
- Allergic reactions: skin rash, itch, hyperthermia, arthralgia.
- Other: very seldom - a gynecomastia, a menorrhagia, tendency to bleedings and hemorrhages.

Rifampicin
- From the alimentary system: nausea, vomiting, diarrhea, a loss of appetite, erosive gastritis, a pseudomembranous coloenteritis, increase in activity of hepatic transaminases in blood serum, a hyperbilirubinemia, hepatitis.
- Allergic reactions: urticaria, eosinophilia, Quincke's disease, bronchospasm, arthralgia, fever.
- From a nervous system: headache, decrease in visual acuity, ataxy, disorientation.
- From an urinary system: нефронекроз, intersticial nephrite, acute renal failure.
- Other: leukopenia, dysmenorrhea, induction of a porphyria, myasthenia, hyperuricemia, exacerbation of gout, grippopodobny syndrome, skin reactions, hemolitic anemia, Werlhof's disease.

Pyrazinamidum
- From the alimentary system: nausea, vomiting, diarrhea, metal smack in a mouth, an abnormal liver function (a loss of appetite, morbidity of a liver, a hepatomegalia, jaundice, a yellow hepatatrophia), an aggravation of a round ulcer.
- From a nervous system: dizziness, a headache, sleep disorders, a hyperexcitability, depressions, in some cases - hallucinations, spasms, confusion of consciousness.
- From bodies of a hemopoiesis: thrombocytopenia, sideroblastny anemia, vacuolation of erythrocytes, porphyria, hypercoagulation, splenomegaly.
- From a musculoskeletal system: arthralgia, mialgiya.
- From an urinary system: dysuria, intersticial nephrite.
- Allergic reactions: skin rash, small tortoiseshell.
- Other: hyperthermia, acne, hyperuricemia, exacerbation of gout, photosensitization, increase in concentration of serumal iron.

Ethambutolum
- From a nervous system: weakness, a headache, dizziness, consciousness disturbance, a disorientation, hallucinations, a depression, peripheral neuritis (paresthesias in extremities, numbness, paresis, an itch).
- From sense bodys: an optic neuritis (decrease in visual acuity, disturbance of color perception, generally - green and red colors, color-blindness, scotoma).
- From the alimentary system: loss of appetite, nausea, vomiting, gastralgia, increase in activity of hepatic transaminases.
- Allergic reactions: dermatitis, skin rash, itch, arthralgia, fever, anaphylaxis.
- Other: hyperuricemia, exacerbation of gout.

Pyridoxine
- Allergic reactions, hypersecretion of hydrochloric acid, numbness, emergence of feeling of a prelum of extremities - a symptom of "stockings" and "gloves", it is rare - rash, a skin itch.

Interaction with other medicines:

Reception of an isoniazid, rifampicin, Ethambutolum and, especially, Pyrazinamidum in the combined dosage form considerably increases antimicrobic activity concerning tuberculosis mycobacteria.

Rifampicin induces some enzymes of system of P450 cytochrome, accelerating metabolism of Prednisolonum, Phenytoinum, quinidine, peroral anticoagulants, hormonal contraceptives, antifungal drugs, Cimetidinum, cyclosporine.

The isoniazid reduces communication of rifampicin with proteins of plasma, Pyrazinamidum slows down rifampicin excretion.

PASK worsens rifampicin absorption.

Reception of rifampicin with lomefloksatsiny and ofloksatsiny leads to decrease in antimicrobic activity of these combinations concerning tuberculosis mycobacteria.

Antacids, opioid analgetics reduce bioavailability of rifampicin.

Isoniazid: MAO inhibitors increase risk of development of side effects from TsNS, cardiovascular system.

The pyridoxine, glutaminic acid reduce risk of development of side effects of an isoniazid.

Joint reception of an isoniazid and Cycloserinum increases risk of development of neurotoxic side effects.

Pyrazinamidum increases concentration of an isoniazid and rifampicin in blood serum, slowing down their excretion. At reception of rifampicin together with Pyrazinamidum a hepatotoxic raises.

Aluminum hydroxide reduces absorption of Ethambutolum.

Reception of Ethambutolum with aminoglycosides, ciprofloxacin, imipenemy, carbamazepine, lithium salts, quinine strengthens risk of neurotoxic effect of medicines.

Ethambutolum increases antimicrobic activity of other antituberculous remedies.

The pyridoxine weakens action of a levodopa at their combined use, reduces risk of development of toxic action of antituberculous remedies on TsNS and a peripheral nervous system.

Contraindications:

— hypersensitivity;
— diseases of a liver and a GIT in an acute stage;
— TsNS diseases (including epilepsy, other diseases with tendency to convulsive attacks);
— diseases of organs of sight (optic neuritis, cataract, diabetic retinopathy, inflammatory diseases of eyes);
— children's age (up to 13 years);
— pregnancy;
— lactation period.

With care: hypothyroidism, hyperuricemia, gout.

Use at pregnancy and feeding by a breast
Contraindications: pregnancy; lactation period.

Use at abnormal liver functions
Contraindication — diseases of a liver of an acute stage.

Use for children
Contraindication — children's age (up to 13 years).

Overdose:

There are no data.

Storage conditions:

List B.: In the dry, protected from light place, at a temperature not above 25 °C. At the controlled room temperature, far from sources of heat and moisture.

Issue conditions:

According to the recipe

Packaging:

Tablets, покр. film obol.: 100 pieces.