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Mebendazolum

Препарат Мебендазол. SC Balkan Pharmaceuticals SRL (Балкан Фармасьютикалс) Республика Молдова


Producer: SC Balkan Pharmaceuticals SRL (Balkans Pharmasyyutikals) Republic of Moldova

Code of automatic telephone exchange: P02CA01

Release form: Firm dosage forms. Tablets.

Indications to use: Enterobiosis. Ascaridosis. Ankilostomidoz. Strongyloidosis. Trichuriasis. Nematodoses. Echinococcosis. Teniosis. Alveococcosis. Kapillyarioz. Gnatostomoz. Trichinosis. Helminthoses.


General characteristics. Structure:

Active ingredient: 100 mg of Mebendazolum in 1 tablet.

Drug with a wide range of protivogelmintny action.




Pharmacological properties:

Pharmacodynamics. Interferes with synthesis of a cellular tubulin, breaks utilization of glucose and slows down formation of ATP at helminths.

Pharmacokinetics. Slowly it is also incomplete (5–10% of a dose) it is soaked up from a GIT. T1/2 is 2,5–5,5 h. In blood for 90% contacts proteins. It is distributed on bodies unevenly. Collects in fatty tissue, a liver, larvae of helminths. In a liver about 2 amin derivatives biotransformirutsya. More than 90% of a dose are removed in not changed view with a stake.


Indications to use:

Enterobiosis, ascaridosis, ankilostomidoza, strongyloidosis, trichuriasis, multiple nematodoses, echinococcosis, teniosis, alveococcosis, капилляриоз, гнатостомоз, trichinosis, the mixed helminthoses.


Route of administration and doses:

Inside. At an enterobiosis: to adults and children 10 years — 100 mg once are more senior, children are 2–10 years old — 25–50 mg once. In case of high probability of a repeated invasion — repeatedly in 2–4 weeks in the same doses. It is recommended to carry out simultaneous treatment of all family members.

At an ascaridosis, a trichuriasis, an ankilostomidoza, a teniosis, a strongyloidosis and the mixed helminthoses: on 100 mg in the morning and in the evening within 3 days.

At a trichinosis: 200–400 mg 3 times a day within 3 days, and from the 4th on the 10th — on 400–500 mg 3 times a day.

At an echinococcosis: on 500 mg 2 times a day the first 3 days and 3 times a day in the next 3 days. Further the dose is raised to maximum (at the rate of 25–30 mg/kg/days) in 3–4 receptions.


Features of use:

Use at pregnancy and feeding by a breast. Category of action on a fruit on FDA — C. For the period of treatment it is necessary to stop breastfeeding.

The periodic research of smears of proctal area and calla after the end of treatment is obligatory: therapy is considered effective in the absence of helminths or their eggs within 7 next days. It is necessary to avoid joint use with alcohol and greasy food, laxative drugs. It is necessary to control a pattern of peripheral blood, function of a liver and kidneys.


Side effects:

Dizziness, nausea, abdominal pain. At use in high doses for a long time: vomiting, diarrhea, headache, increase in activity of hepatic transaminases, hypercreatinemia, leukopenia, anemia, eosinophilia, hair loss, hamaturia, cylindruria, allergic reactions (skin rash, small tortoiseshell, Quincke's disease).


Interaction with other medicines:

Carbamazepine and other inductors of metabolism lower, and Cimetidinum — increases concentration in fabrics.


Contraindications:

Hypersensitivity, nonspecific ulcer colitis, disease Krone, a liver failure, pregnancy, feeding by a breast, children's age up to 2 years.


Overdose:

Symptoms: nausea, vomiting, diarrhea, abdominal pain. At prolonged use in high doses: reversible abnormal liver functions, hepatitis, neutropenia.

Treatment: gastric lavage, enemas, reception of absorbent carbon; there is no specific antidote.


Storage conditions:

To store at a temperature of 15-25 °C, in dry, protected from light and the place, unavailable to children. Period of validity 3 years. Not to use after the expiry date specified on packaging.


Issue conditions:

Without recipe


Packaging:

Tablets of 100 mg, 10 tablets in each blister, on one, two or three blisters together with the application instruction in cardboard packaging.



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