Mebendazolum

General characteristics. Structure:

Active ingredient: 100 mg of Mebendazolum.

Excipients - starch corn, sodium glikolit starch, calcium phosphate double-base, povidone, talc, magnesium stearate fragrance pineapple (dry).

Highly effective means.

Pharmacological properties:

Pharmacodynamics. Affects different types of helminths, but it is most effective at an enterobiosis and a trichuriasis. It can also be applied at an ascaridosis, an ankilostomidoza, a teniidoza and the mixed invasions.

Drug selectively strikes cytoplasmatic mikrotubula of helminths, assimilation by helminths of glucose oppresses and slows down education in their organism of ATP.

After intake Mebendazolum is a little absorbed. A small part of active agent, getting to blood, for 90% contacts proteins of plasma and it is metabolized in a liver. Drug is badly soaked up in intestines and is almost completely emitted with a stake (only in insignificant quantities with urine).

Pharmacokinetics. Practically it is not soaked up in intestines. T1/2 is 2.5-5.5 h. Communication with proteins of plasma - 90%. It is distributed on bodies unevenly, collects in fatty tissue, a liver, larvae of helminths. In a liver about 2 amin derivatives are metabolized. More than 90% of a dose are allocated with a fecal masses in not changed look. The soaked-up part (5-10%) is removed by kidneys.

Indications to use:

Enterobiosis, trichuriasis, ascaridosis, анкилостомидоз, a strongyloidosis, a trichinosis, a teniosis, an echinococcosis, multiple nematodes, an alveococcosis, капилляриоз, гнатостомоз, the mixed helminthoses.

Route of administration and doses:

Inside, with a small amount of water.

To adults and children 10 years at an enterobiosis are more senior - once, on 100 mg. To children aged from 2 up to 10 years - once, on 25-50 mg. In case of high probability of a repeated invasion accept repeatedly in 2-4 weeks in the same dose. It is recommended to carry out simultaneous treatment of all family members.

At an ascaridosis, a trichuriasis, a dochmiasis, a teniosis, a strongyloidosis and the mixed helminthoses - in the morning and in the evening on 100 mg within 3 days.

At a trichinosis - 3 times a day on 200-400 mg within 3 days, and from 4 to 10 day - 3 times on 400-500 mg.

At an echinococcosis in the first 3 days - on 500 mg 2 times a day, in the next 3 days increase a dose to 500 mg 3 times a day; further the dose is raised to maximum (at the rate of 25-30 mg/kg/days) and accepted in 3-4 receptions.

Features of use:

It is necessary to avoid joint use with alcohol and greasy food, laxative drugs.

At use of Mebendazolum observance of a diet is not required.

Children to 1 годаМебендазол should appoint only if the helminthic invasion exerts serious negative impact on process of food and physical development.

The periodic research of smears of proctal area and calla after the end of treatment is obligatory: therapy is considered effective in the absence of helminths or their eggs within 7 next days.

It is necessary to control a pattern of peripheral blood, function of a liver and kidneys.

Side effects:

Dizziness, nausea, abdominal pain.

At use in high doses for a long time: vomiting, diarrhea, headache, allergic reactions (skin rash, small tortoiseshell, Quincke's disease), hair loss; hepatitis; increase in activity of "hepatic" transaminases, giperkreatininemiya; leukopenia, anemia, neutropenia, eosinophilia, hamaturia, cylindruria.

Can exert negative impact on fetation.

Interaction with other medicines:

Joint appointment with Cimetidinum can lead to strengthening of effect of Mebendazolum at the expense of inhibition of metabolism of Mebendazolum in a liver and increases in concentration in plasma.

Mebendazolum reduces the need for insulin at patients with a diabetes mellitus.

It is necessary to avoid joint appointment with lipophilic substances.

Carbamazepine, etc. inductors of metabolism lower concentration of Mebendazolum in fabrics.

Contraindications:

- hypersensitivity,
- nonspecific ulcer colitis, disease Krone,
- children's age till 1 year,
- pregnancy,
- lactation period;
- the expressed abnormal liver functions, a liver failure.

Overdose:

Simptomy:bol in a stomach, nausea, vomiting, diarrhea. At use in high doses for a long time: reversible abnormal liver functions, hepatitis, neutropenia.

To remove with Lecheniye:neobkhodimo drug from a stomach, having caused vomiting or having made a gastric lavage, reception of absorbent carbon.

Storage conditions:

List B. In the place protected from moisture and light at a temperature not above +25 °C.
To store in the place, unavailable to children. Period of storage 3 years.

Issue conditions:

According to the recipe

Packaging:

On 6 tablets in blister strip packagings, on 1 packaging in a cardboard pack.