Vormil

General characteristics. Structure:

Active ingredient: 200 mg of an albendazl in 10 g of powder.

Excipients: sakhroza, sorbite (Е 420), silicon dioxide colloid anhydrous, sodium citrate, citric acid monohydrate, sodium chloride, oranzh fragrance, yellow decline (supra of E110), xanthane gum, aspartame (E951).

Protivogelmintny drug with a broad spectrum of activity.

Pharmacological properties:

Pharmacodynamics. Vormil - protivogelmintny drug with a broad spectrum of activity. Active agent – albendazole. Albendazole is effective at fabric and intestinal forms of parasitic diseases. Affects both adults of helminths, and their larvae and eggs. The Protivogelmintny effect is caused by ability of albendazole to suppress polymerization of a tubulin that causes disturbance of metabolism of helminths with their further death.

Shows action concerning intestinal helminths (a nematode of Enterobius vermicularis, Ascaris lumbricoides, Trichiurus trichiura, Strongiloides stercoralis, Necator americanus, Cutaneous Larva Migrans Ancylostoma duodenale; cestodes of Taenia solium, Hymenolepsis nana, Taenia saginata; trematodes of Clonorchis sinensis and Opisthorhis viverrini), and also the elementary organisms (Giardia lamblia). It is active at fabric helminthoses (Echinococcus granulosus – a cystic echinococcosis and Echinococcus multilocularis - an alveolar echinococcosis). Albendazole also with is effective in therapy of an invasion of larvae of T. Solium (нейроцистецеркоз) and Gnatostoma spinigerum (капилляриоз). At Vormil's use decrease in sizes or cysts of a granular echinococcus are liquidated.

Pharmacokinetics. After internal reception albendazole from digestive tract is soaked up badly – approximately to 5%. At the use of greasy food, simultaneous with albendazole, increase in absorption of substance is observed. At primary passing through a liver it is quickly metabolized. The main metabolite – albendazole sulfate – is active for 50% of effect of primary substance. An elimination half-life – 8,5 hours. Metabolites of albendazole are brought out of an organism with bile (preferential) and urine (small amounts). At reception for a long time (in high doses for treatment of cysts) removal of metabolites from cysts is observed for several weeks.

Indications to use:

At parasitic invasions (a dochmiasis, an enterobiosis, a necatoriasis, a teniosis, a strongyloidosis, a hymenolepiasis, an ascaridosis, trichinosis, капилляроз, a trichinosis, the skin migrating larvae, a clonorchosis, гнатостомоз, токсокароз, a lambliasis at children).

Route of administration and doses:

The dose is established individually.

At an enterobiosis, a dochmiasis, a necatoriasis, an ascaridosis, trichinosis at adults and children 2 years are more senior use drug inside on 400 mg of 1 times a day for 3–5 days.

At a strongyloidosis, a teniosis and a hymenolepiasis to adults and children 2 years drug are more senior appoint 400 mg of 1 times a day for 3 days.

At the confirmed hymenolepiasis the course of treatment is repeated in 3 weeks.

At an opisthorchosis and a clonorchosis to adults and children 2 years drug are more senior appoint 400 mg 2 times a day for 3 days. The specified scheme of treatment is effective also at the mixed invasion of Opisthorchis viverrini and Chlonorchis sinensis.

At a lambliasis at children at the age of 2–12 years drug is used on 400 mg of 1 times a day for 5 days.

At system helminthic invasions the dose of drug depends on a species of a parasite, body weight of the patient and disease severity.

At a cystic echinococcosis at patients with body weight more than 60 kg Vormil apply on 1 tablet 2 times a day for 28 days. To patients with body weight less than 60 kg — in a daily dose of 15 mg/kg in 2 receptions (the maximum dose — 800 mg/days). The course of treatment can be repeated with an interval of 14 days, if necessary it is possible to carry out 3 such cycles.

At an alveolar echinococcosis at patients with body weight more than 60 kg Vormil apply on 1 tablet 2 times a day throughout 3 cycles for 28 days with 14-day breaks. At patients with body weight less than 60 kg Vormil apply in a daily dose 15 mg/kg in 2 receptions (the maximum dose of 800 mg/days). If necessary treatment is continued within several months or years.

At the skin migrating larvae (Cutaneous larva migrans) drug is used on 1 tablet for 1 - 3 days.

At a neyrotsistetsirkoza at patients with body weight more than 60 kg Vormil apply on 1 tablet 2 times a day for 7–30 days depending on result, with body weight less than 60 kg — in a daily dose of 15 mg/kg in 2 receptions (the maximum dose — 800 mg/days). The course of treatment can be repeated in 1–2 weeks.

Features of use:

Short-term treatment of intestinal infections and skin syndrome of Larva Migrans. To prevent Vormil's reception during early durations of gestation, women of reproductive age, it is necessary to treat in the first week after periods or after the negative test for pregnancy. During therapy reliable contraception is necessary.

Treatment by albendazole can find existence of already existing neurocysticercosis, especially in territories with the high level of infection with Tenia solium strains. Patients can have neurologic symptoms, for example spasms, increases in intracranial pressure and focal symptoms, as a result of the inflammatory reaction caused by death of parasites in a brain. Symptoms can quickly arise after treatment therefore it is necessary to begin immediately the corresponding therapy with corticosteroids and anticonvulsant drugs.

Long-term treatment of system infections of helminths. Treatment by albendazole is followed by weak or moderate increase in level of liver enzymes that is usually normalized after the treatment termination. Therefore the level of liver enzymes should be checked before each course of treatment and at least each 2 weeks during treatment. If the level of liver enzymes considerably increases (more than twice in comparison with an upper limit of norm), treatment by albendazole should be stopped. Treatment can be updated after normalization of level of enzymes, but the condition of the patient should be controlled carefully.

Albendazole can attract oppression of marrow therefore it is necessary to carry out blood tests of the patient as in an initiation of treatment, and each 2 weeks during 28-day to a cycle. Patients with a liver disease, including a hepatic echinococcosis, more inclined to oppression of marrow, result of what are emergence of a pancytopenia, aplastichny anemia, an agranulocytosis and leukemia which predetermines need of careful control of indicators of blood. In case of considerable falling of indicators of blood treatment should be stopped.

It is possible to apply when carrying out deworming before vaccination, and also to preventive treatment and 2 times for a year.

Patients with neurocysticercosis who are treated by albendazole can have symptoms (for example spasms, increases in intracranial pressure and focal symptoms) connected with the inflammatory reaction caused by death of parasites. It it is necessary to treat corticosteroids and anticonvulsant drugs. Within the first week of treatment it is recommended to apply peroral or intravenous corticosteroids to prevention of emergence of cases of increase in cerebral pressure.

To prevent Vormil's use to women on early durations of gestation, and also to women of reproductive age, it is necessary to begin treatment only after the negative test for pregnancy; to prevent about need use of effective remedies of contraception during treatment by drug and within a month after its cancellation.

Ability to influence speed of response at control of motor transport or work with other mechanisms. Considering existence of such side reaction as dizziness, it is recommended to abstain for use of albendazole from control of motor transport or work with other mechanisms.

Side effects:

From the alimentary system: vomiting, dryness in a mouth, stomatitis, heartburn, a meteorism, nausea, an abdominal pain, diarrhea, a lock.

From a nervous system: headache, drowsiness or sleeplessness, dizziness, disorientation, confusion of consciousness, hallucination, spasm.

From an organ of sight: decrease in visual acuity.

Hypersensitivity reactions: urticaria, dermatitis, itch, pemphigus, fever.

System of blood: pancytopenia, leukopenia.

Interaction with other medicines:

Increase in concentration of metabolites of albendazole at a combination to a prazikvantel, Cimetidinum and dexamethasone is possible.

Contraindications:

• pregnancy and feeding by a breast;
• reactions of hypersensitivity to albendazole or other components of Vormil;
• age up to 2 years;
• pregravidarny period.

Overdose:

At Vormil's overdose the following symptoms are possible: a vision disorder, vomiting, nausea, drowsiness, visual hallucinations, dizziness, a hepatomegalia, disturbance of the speech, a loss of consciousness, jaundice, orange or brown-red coloring of urine, skin, saliva, sweat, got down also a calla.

Treatment: a gastric lavage, purpose of enterosorbents, the supporting and symptomatic therapy.

Storage conditions:

To store in the place protected from light and children at a temperature not over 25 ºС. Period of validity 2 years.

Issue conditions:

According to the recipe

Packaging:

On 10 g of powder in a bag, on 10 bags in a paper pack together with the application instruction.