Retinolum acetate kaps. 33 000 ME, No. 25 of bank (in a pack)

General characteristics. Structure:

One capsule contains: active components: Retinolum acetate solution for intake and external use of oil 8,60% - 0,132 ml (33000 ME) excipients: the sunflower oil refined deodorized structure of a cover: gelatin, глицерол (glycerin), methylparahydroxybenzoate (нипагин), dye quinoline yellow (dye quinolinic yellow E-104).

Pharmacological properties:

Vitamin A has fortifying effect, normalizes fabric exchange; participates in oxidation-reduction processes (owing to a large number of unsaturated bonds), in synthesis of mucopolysaccharides, proteins, lipids, in mineral exchange, processes of formation of cholesterol. Strengthens development of a lipase and trypsin, strengthens a myelopoiesis, processes of cellular division. Exerts positive impact on function of the lacrimal, grease and sweat glands; increases resistance to diseases of mucous membranes of respiratory tracts and intestines; increases resistance of an organism to an infection. Strengthens division of epithelial cells of skin, rejuvenates cell population, slows down processes of keratinization, strengthens synthesis of glikozaminoglikan, activates interaction of immunocompetent cells among themselves and epidermis cells. Stimulates regeneration of skin. Participates in photoreception processes (promotes adaptation of the person to darkness). Local action is caused by existence on a surface of cells of an epithelium of specific retinolsvyazyvayushchy receptors.

Indications to use:

Hypovitaminosis, A. V avitaminosis of complex therapy: - infectious and inflammatory diseases (dysentery, flu, tracheitises, bronchitis, etc.); - defeats and diseases of skin (skin cracks, an ichthyosis, a hyperkeratosis, seborrheal dermatitis, psoriasis, neurodermatitis, some forms of eczema, a tuberculosis cutis); - diseases of eyes (a pigmental retinitis, a hemeralopia, a xerophthalmia, a keratomalacia, eczematic defeats a century); - gastrointestinal diseases (an erosive gastroduodenit, a peptic ulcer of a stomach and a duodenum); - cirrhosis.

Route of administration and doses:

Use of drug needs to be carried out under observation of the doctor. Drug is accepted inside after food early in the morning or late at night. Medical doses for adults at avitaminosis easy and moderate severity make to 33000 ME/days. At diseases of eyes appoint the adult - 100000 ME Retinolums of acetate a day and at the same time 0,02 g of Riboflavinum. At diseases of skin appoint the adult in days 100000 ME Retinolums of acetate. The daily dose for adults should not exceed 100000 ME.

Features of use:

Do not accept at the same time other polyvitaminic complexes containing vitamin A in overdose avoidance.

Side effects:

Allergic reaction to drug components, a hypervitaminosis And.

Interaction with other medicines:

During long therapy tetracyclines do not recommend to appoint vitamin A (the risk of development of intracranial hypertensia increases). Salicylates and glucocorticosteroids reduce risk of development of side effects. Colestyraminum, колестипол, mineral oils, Neomycinum reduce vitamin A absorption (increase in a dose can be required). Oral contraceptives increase concentration of vitamin A in plasma. Izotretionin increases risk of emergence of toxic effect. Weakens effect of the drugs Sa2+, increases risk of development of a hypercalcemia. Vitamin E reduces toxicity, absorption, deposition in a liver and vitamin A use; high doses of vitamin E can lower vitamin A reserves in an organism.

Contraindications:

Hypersensitivity to drug components, a hypervitaminosis And, pregnancy, cholelithiasis, chronic pancreatitis, acute inflammatory diseases of skin, children's age.

Overdose:

Symptoms of acute overdose (develop in 6 h after introduction): hypervitaminosis And: adults have a drowsiness, slackness, doubling in eyes, dizziness, a severe headache, nausea, pernicious vomiting, diarrhea, irritability, osteoporosis, an odontorrhagia, dryness and an ulceration of a mucous membrane of an oral cavity, a peeling of lips, skin (especially palms), confusion of consciousness, increase in intracranial pressure (children of chest age have a hydrocephaly, protrusion of a fontanel). Symptoms of chronic intoxication: appetite loss, an ostealgia, cracks and a xeroderma, lips, dryness of a mucous membrane of an oral cavity, a gastralgia, vomiting, a hyperthermia, an adynamy, increased fatigue, a headache, photosensitivity, a pollakiuria, a nocturia, a polyuria, an acrimony, a hair loss, yellow-orange spots on soles, palms, in the field of a nasolabial triangle, the hepatotoxic phenomena, intraocular hypertensia, an oligomenorrhea, portal hypertensia, hemolitic anemia, changes of bones on roentgenograms, spasms; fetotoksichesky phenomena: malformations of an urinary system, growth inhibition, early closing of epiphyseal regions of growth. Treatment: drug withdrawal, symptomatic therapy.

Storage conditions:

List B. In dry, protected from light and the place, unavailable to children, at a temperature not above 25 °C.

Issue conditions:

Without recipe

Packaging:

Capsules 33000 ME. On 25 or 50 capsules in the banks from glass melt of orange glass corked by polyethylene covers. On 10 capsules in a blister strip packaging from a film of polyvinyl chloride and aluminum foil. Each can or 3 or 5 blister strip packagings together with the application instruction are placed in a pack from a cardboard.