Риназолин® (drops of 0,1 mg/ml)

General characteristics. Structure:

Active ingredient: oxymetazoline;

1 ml of drops contains hydrochloride oxymetazoline in terms of 100% substance of 0,1 mg;

excipients: a benzalkoniya chloride, sodium chloride, sodium dihydrophosphate a dihydrate, sodium hydrophosphate dodecahydrate, water for injections.

Pharmacological properties:

Rinazolin treats group of local vasoconstrictors (dekongensant). Renders alpha адреномиметическое action.

Narrows vessels in a site of application, reduces a rhinedema and upper respiratory tracts, reduces allocations from a nose. Recovers nasal breath. Promotes recovery of aeration of adnexal bosoms, a tympanic cavity that prevents development of bacterial complications (antritis, sinusitis, average otitis).

Oxymetazoline renders antiviral, antiinflammatory, immunomodulatory and antioxidant action. Thanks to this combined action mechanism during conduct of clinical trials more bystry and effective elimination of symptoms of acute rhinitis (a nose congestion, a rhinorrhea, sneezing, deterioration in health) was proved.

At topical nasal administration in therapeutic concentration does not irritate a mucous membrane of a nose, does not cause a hyperemia. Action duration – till 12 o'clock.

Indications to use:

The acute respiratory diseases which are followed by a nose congestion; allergic rhinitis, vasculomotor rhinitis; for recovery of a drainage and nasal breath at diseases of adnexal bosoms of a nasal cavity, an eustachitis at children till 1 year. For elimination of hypostasis before diagnostic manipulations in the nasal courses at children till 1 year.

Route of administration and doses:

Just before use it is necessary to take a bottle with drug in a palm to warm up it to body temperature. Before administration of drug it is necessary to clean a nose carefully. Prior to use densely not to twist a cap! Before the first use of drug it is necessary to twirl a bottle cap for formation of an opening. After an instillation the cap needs to be twirled densely. The cap is unscrewed, removed and, slightly pressing on the bottle case, dig in 1-2 drops of solution in a nose.

The newborn aged up to 4 weeks appoint on 1 drop 0,01% of solution in each nasal course 2-3 times a day. From the 5th week of life to 1 year – on 1-2 drops in each nasal course 2-3 times a day.

Efficiency of such procedure is proved: depending on age 1-2 drops of 0,01% of solution apply on vatu and wipe the nasal courses.

It is necessary to use drug no more than 5-7 days. Drug can be used repeatedly only in several days.

Features of use:

Use during pregnancy or feeding by a breast. During pregnancy and feeding by a breast drug is used with extra care. Exceeding of the recommended dosing is not allowed.

Ability to influence speed of response at control of motor transport or work with other mechanisms. After prolonged use of oxymetazoline in the doses exceeding recommended it is impossible to exclude the general influence on cardiovascular system. In such cases ability to manage the vehicle can decrease.

Children. To apply Rinazolin 0,01% to children till 1 year.

Side effects:

From respiratory system: discomfort in a nose, burning or a xeromycteria, sneezing, nasal bleeding.

After the effect of Rinazolin's use comes to an end, the feeling of a strong congestion of a nose can be observed (reactive hyperemia). An apnoea at newborns and children of younger age (especially in case of overdose).

From a nervous system: a headache, drowsiness, fatigue, spasms, hallucinations (especially at children).

From cardiovascular system: topical nasal administration can cause system effects, such as palpitation, tachycardia, arterial hypertension.

From immune system: emergence of allergic reactions, including rashes, an itch, a Quincke's disease is possible.

Interaction with other medicines:

Not to use the MAO inhibitors and other drugs promoting increase in arterial pressure because of risk of increase in arterial pressure. Joint purpose of other vasoconstrictive medicines increases risk of development of side effects.

Contraindications:

Hypersensitivity to drug components, atrophic rhinitis. At use of monoamine oxidase inhibitors and for 2 weeks after the treatment termination by MAO inhibitors, and also other drugs which promote increase in arterial pressure. With the increased intraocular pressure, especially at closed-angle glaucoma. At severe forms of cardiovascular diseases (for example coronary heart disease, arterial hypertension). Pheochromocytoma. Metabolic disturbances (hyperthyroidism, diabetes mellitus, porphyria). Prostate hypertrophy.

Appropriate security measures at use

 

It is necessary to avoid prolonged use and overdose of drug. Prolonged use of an antiedematous for a nose can lead to weakening of effect of drug. Abuse of this means can cause a mucosal atrophy and a reactive hyperemia with medicamentous rhinitis.

After use of drug special observation of patients with chronic rhinitis and in cases of elimination of hypostasis before diagnostic manipulations is necessary. Doses are higher than recommended, it is necessary to apply only under observation of the doctor.

Overdose:

After considerable overdose or accidental intake there can be such symptoms: a mydriasis, nausea, vomiting, cyanosis, fervescence, spasms, tachycardia, palpitation, arrhythmia, cardiovascular insufficiency, a cardiac standstill, the raised potovydeleniye, agitation, convulsions, arterial hypertension, a fluid lungs, respiratory disturbances, pallor, a miosis, a hyposmia, mental disorders.

Besides, there can be an oppression of functions of the central nervous system which is shown drowsiness, decrease in body temperature, bradycardia, arterial hypotension, an apnoea and possible development of a coma.

Therapeutic measures at overdose: gastric lavage, reception of absorbent carbon, ventilation of the lungs. At lowering of arterial pressure to apply phentolamine. It is not necessary to accept angiotonic means. If necessary anticonvulsant therapy is shown.

Storage conditions:

Period of validity 3 years. Not to use drug after the termination of the period of validity specified on packaging. To store in the place protected from light at a temperature not over 25 ºС. To store in the place, unavailable to children.

Issue conditions:

Without recipe

Packaging:

On 10 ml in a bottle polyethylene. On 1 bottle in a pack.