Aevitum

General characteristics. Structure:

Active ingredients: 100 mg an alpha - tocopherol of acetate (vitamin E), 100 000 PIECES of Retinolum of palmitate (vitamin A).

Excipients: oil sunflower.

Structure of a cover of a gelatin capsule: gelatin pharmaceutical, глицерол, methylparahydroxybenzoate, пропилпарагидроксибензоат, the water purified dyes: red charming E - 129, quinolinic yellow E - 104, diamond blue E - 133.

Pharmacological properties:

Pharmacodynamics. The combined drug which effect is defined by properties of the fat-soluble vitamins A which are its part and E.

Retinolum (vitamin A) - fat-soluble vitamin, as a cofactor plays an important role in oxidation-reduction processes, participates in synthesis of mucopolysaccharides, proteins, lipids. It is necessary for normal reproductive function, embryonic development, proliferation and a differentiation of an epithelium and bone formation. Participates in formation of the rhodopsins necessary for normal twilight and color sight. Retinolum increases immunity, weakens effects of a number of infectious diseases, can interfere with development of malignant new growths.

α-tocopherol acetate (vitamin E) has antioxidant properties, interfering with action of free radicals on biological membranes participates in protein synthesis, proliferation of cells, tissue respiration. Maintains stability of erythrocytes and prevents their hemolysis, interferes with a hyperpermeability and fragility of capillaries, increases resistance of fabrics to a hypoxia, favorably influences the broken lipidic exchange.

Vitamin E promotes prevention of a misbirth, normalization of function of gonads at men, to recovery of skeletal muscles at muscular dystrophy and other damages of muscles. At cardiovascular diseases in complex therapy vitamin E contributes to normalization of metabolism in a heart muscle, increases blood-groove speed in arterioles, supports tension in venules.

Pharmacokinetics. Retinolum palmitate is well soaked up in upper parts of a small intestine, gets into lymphatic ways and comes to a liver. After introduction the maximum concentration in plasma is reached in 4 hours. Retinolum is distributed in an organism unevenly. Its greatest number is in a liver and a retina, it is found in kidneys, fat depos, adrenal glands and other hemadens. Products of exchange of Retinolum are allocated with kidneys. An elimination half-life – 9,1 hours.

α-tocopherol acetate is soaked up in a GIT, the most part gets to a lymph, is quickly distributed in all fabrics, allocated with bile and in the form of metabolites with urine.

Indications to use:

- Hypo - and avitaminosis of A and E,

- conditions of the increased need of an organism for vitamins A and E and/or decrease in their receipt in an organism,

- at the raised exercise and intellectual stresses, stressful states;

- during recovery after the long and/or hard proceeding diseases, including infectious;

- at asthenic conditions of various etiology;

- at unbalanced and defective food.

Route of administration and doses:

The Aevitum capsules accept inside, irrespective of meal, daily on 1 capsule within 20-40 days with intervals of 3-6 months.

Features of use:

With care appoint at cholecystitis, acute and chronic nephrite, states with a hyperpermeability of vessels, to patients with a myocardial infarction.

It is not recommended to appoint for a long time together with other polyvitaminic drugs since the overdose of fat-soluble vitamins is possible (And yes E).

It is necessary to observe strictly instructions on dosing since the hypervitaminosis is possible And.

The teratogenic effect of the raised doses of vitamin A remains also after the termination of its reception therefore it is recommended to plan pregnancy at drug use only in 6-12 months.

At use of drug it is necessary to consider high content of vitamin A in it (100 thousand ME) and also that it is medical, but not preventive medicine.

Does not influence a possibility of driving of the car and work with the equipment.

Side effects:

At prolonged use high doses of vitamin A can cause the phenomena of a hypervitaminosis And (drowsiness, slackness, a headache, short-term temperature increase, a skin peeling, skin rashes, disorders of gait, morbidity in the lower extremities). In rare instances the dispeptic phenomena in the form of feeling of discomfort in epigastric area, nausea, vomitings can be observed.

Interaction with other medicines:

At simultaneous use vitamin A weakens effect of the drugs Ca2+, increases risk of development of a hypercalcemia.

Colestyraminum, колестипол, mineral oils, Neomycinum reduce adsorption of vitamin A and E (increase in their dose can be required).

Oral contraceptives increase concentration of vitamin A in plasma.

Retinolum lowers antiinflammatory action of glucocorticoids.

Izotretinoin increases risk of development of intoxication by vitamin A.

Simultaneous use of tetracycline and vitamin A in high doses (50 thousand. Pieces and above) increase risk of development of intracranial hypertensia.

Vitamin E strengthens effect of GKS, NPVP, antioxidants, increases efficiency and reduces toxicity of vitamins A, D, cardiac glycosides.

Vitamin E increases efficiency of antiepileptic HP at patients with epilepsy (at whom the content in blood of products of peroxide oxidation of lipids is increased).

Simultaneous use of vitamin E in a dose more than 400 PIECES/days with anticoagulants (derivatives of coumarin and an indandion) increases risk of development of a prothrombinopenia and bleedings. High doses of Fe strengthen oxidizing processes in an organism that increases the need for vitamin E.

acetate it is not recommended to accept α-tocopherol in combination with drugs of gold, silver, shchelochnoreagiruyushchy means.

Corticosteroid drugs, antibiotics of tetracycline group, and also ethanol and etanolsoderzhashchy drugs at combined use with Aevitum reduce therapeutic effect.

Contraindications:

Contraindications to use of the Aevitum capsules are the hypervitaminosis of A and E, a thyrotoxicosis, a chronic glomerulonephritis, chronic heart failure, hypersensitivity to drug components, a sarcoidosis in the anamnesis, children's age up to 14 years.

Drug is contraindicated at pregnancy.

Overdose:

Symptoms of acute overdose of vitamin A (develop in 6 h after introduction) at adults - drowsiness, slackness, a diplopia, dizziness, a severe headache, nausea, pernicious vomiting, diarrhea, irritability, osteoporosis, an odontorrhagia, dryness and an ulceration of a mucous membrane of an oral cavity, a peeling of lips, skin (especially palms), excitement, confusion of consciousness, increase in intracranial pressure; children of chest age have a hydrocephaly, protrusion of a fontanel.

Symptoms of chronic intoxication vitamin A: anorexia, an ostealgia, cracks and a xeroderma, lips, dryness of a mucous membrane of an oral cavity, a gastralgia, vomiting, a hyperthermia, an adynamy, a headache, a photosensitization, a pollakiuria, a nocturia, a polyuria, irritability, a hair loss, yellow-orange spots on soles, palms, in the field of a nasolabial triangle, the hepatotoxic phenomena, increase in intraocular pressure, an oligomenorrhea, portal hypertensia, hemolitic anemia, changes on roentgenograms of bones, spasms; fetotoksichesky phenomena: the person has malformations of an urinary system, a growth inhibition, early closing of epiphyseal regions of growth; at animals - malformations of TsNS, a backbone, thorax, heart, an eye, the upper sky, urinogenital system.

Vitamin E overdose symptoms: at reception during the long period in doses of 400-800 PIECES/days - an illegibility of visual perception, dizziness, a headache, nausea, diarrhea, a gastralgia, an adynamy; at reception more than 800 PIECES/days during the long period - increase in risk of development of bleedings in patients with a hypovitaminosis To, disturbance of metabolism of thyroid hormones, disorders of sexual function, thrombophlebitis, a thrombembolia, necrotic colitis, sepsis, a hepatomegalia, a hyperbilirubinemia, a renal failure, hemorrhage in a mesh cover of an eye, a hemorrhagic stroke, ascites.

Treatment: drug withdrawal; symptomatic therapy.

Storage conditions:

In the dry place protected from light at a temperature from 15 to 25 °C. To store in the place, unavailable to children. Period of validity 2 years.

Issue conditions:

Without recipe

Packaging:

On 10 capsules in a blister strip packaging, on the 2nd blister strip packagings together with the application instruction in a pack from a cardboard bandbox.