DE   EN   ES   FR   IT   PT Medicines Combination vitamins B with various substances. Kardonat


Препарат Кардонат. СП ООО "Сперко Украина" Украина

General characteristics. Structure:

Active ingredient: 1 capsule contains Cobamamidum (a dibenkosid, B12 coenzyme) - 1 mg, cocarboxylase (chloride) (B1 coenzyme) - 50 mg, piridoksal-5-phosphate (B6 coenzyme) - 50 mg; a chloride carnitine - 100 mg, a hydrochloride lysine - 50 mg; excipients: talc, aerosil. main physical and chemical properties: powder from whitish-yellow till light orange color with dark and/or white impregnations;

Pharmacological properties:

Pharmacodynamics. Kardonat — the combined drug which effect is caused by synergy effects of the components which are its part. The L-carnitine trimetilammoniyevy (betainovy) derivative γ-amino-β-gidroksimaslyany acid, belongs to means with anabolic action. It is synthesized in a liver, kidneys and the central nervous system from amino acids of a lysine and methionine with participation of iron and ascorbic acid, in a blood plasma is present at a free form and in the form of atsilkarnitinovy ethers. The carnitine is the main cofactor and the regulator of metabolism of fatty acids in a myocardium, a liver and skeletal muscles, a uniform carrier of dlinnotsepochny fatty acids in a mitochondrion where there is their beta oxidation to atsetil-KOA which is substrate for formation of ATP in a tricarbonic acid cycle. Promotes allocation from cytoplasm of metabolites and toxics, improves metabolic processes. In the conditions of normal oxygen providing transfers metabolism of cells to oxidation of fatty acids as most power-intensive substrate, and in the conditions of a hypoxia the L-carnitine brings toxic metabolites of fatty acids out of mitochondrions, transferring metabolism of a cell to glucose oxidation, carrying out thus anti-hypoxemic action. Increases working capacity, accelerates growth, causes increase in mass of muscles and a degrowth of fatty tissue due to lipolytic action, reduces peripheral effect of thyroid hormones, normalizes standard metabolism at a hyperthyroidism. Reduces symptoms of a physical and mental overstrain, renders neuro, gepato-and cardiotyre-tread action, shows anti-ischemic action, limits a heart attack zone, improves processes of transfer of nervous impulse in synapses and axons by increase in synthesis of sincaline and acetylcholine, glutaminic acid, reduces concentration of ammonia in nervous tissue, stimulates cellular immunity. Eliminates functional disturbances of a nervous system at patients with chronic intoxications, including alcoholic genesis, softens a current of an abstinence syndrome, slows down dystrophic changes of vessels of a retina. The carnitine shows anti-ketogenic action, reducing products of ketonic bodies of higher fatty acids.
The lysine — irreplaceable amino acid, takes part in all processes of assimilation and growth, promotes ossification and growth of a bone tissue, stimulates a mitosis of cells, improves an ovogenesis and a spermatogenesis, has direct antiviral effect on herpes simplex viruses.
B12 vitamin coenzyme (Cobamamidum) has anabolic activity, activates exchange of carbohydrates, proteins and lipids, participates in synthesis of labile methyl groups, in formation of sincaline, methionine, nucleic acids, creatine, promotes accumulation in erythrocytes of connections with sulphhydryl groups. As the growth factor stimulates function of marrow that is necessary for a normoblastny erythrogenesis. Cobamamidum contributes to normalization of the broken functions of a liver and a nervous system, shows anti-ketogenic action, activates system of a blood coagulation, in high doses causes increase in activity of thromboplastin and a prothrombin.
B1 vitamin coenzyme (cocarboxylase) has the regulating effect on exchange processes in an organism. Plays especially important role in carbohydrate and a lipometabolism, first of all in oxidizing decarboxylation of ketonic acids (pyroracemic, α-keto-glutaric, etc.), and also in a pentozofosfatny way of disintegration of glucose. Reduces the level of lactic and pyruvic acid in an organism, improves digestion of glucose, a trophicity of nervous tissue, shows cardiotyre-tread action.
B6 vitamin coenzyme (piridoksal-5-phosphate) plays an important role in a metabolism, is necessary for normal functioning of the central and peripheral nervous system. Is a coenzyme of a large amount of the enzymes operating on not oxidizing exchange of amino acids (processes of decarboxylation, interamination, etc.). Takes part in exchange of tryptophane, methionine, cysteine, glutaminic and other amino acids. Is of great importance for exchange of a histamine as histaminase coenzyme, contributes to normalization of lipidic exchange, increases quantity of a glycogen in a liver, improves its detoksitsiruyushchy properties. Catabolizes neuromuscular processes which are especially important at children's age at a delay of intellectual and physical development, at chronic fatigue and an adynamy.

Pharmacokinetics. It was not investigated.

Indications to use:

Regulation broken carbohydrate, proteinaceous and a lipometabolism, including congenital genetic anomalies of metabolism of higher fatty acids; lag in intellectual and physical development of children (a hypotrophy, anorexia, a growth inhibition, an adynamy); a physical and intellectual overstrain, including at athletes, decrease in working capacity (muscular dystrophy, an atony); anorexia at adults owing to a mental and physical overstrain; coronary heart disease (as a part of a combination therapy of stenocardia, a myocardial infarction); chronic heart failure (as a part of a combination therapy); metabolic cardiopathies, including dishormonal; bronchial asthma and a chronic obstructive disease of lungs (as an immunomodulator as a part of a combination therapy); as a part of a combination therapy of a syndrome of alcohol addiction, including at abstinence; as a part of a combination therapy of acute and chronic disorders of cerebral circulation (brain strokes and chronic disturbances of cerebral circulation, distsirkulyatorny encephalopathy); hyperthyroidism; liver diseases (hepatitises, cirrhoses); a liver and renal failure (as a part of a combination therapy); peripheral neuritis, neuralgia, radiculopathies; the states demanding improvement carbohydrate and a lipometabolism; iron deficiency and B12-scarce anemia (as a part of a combination therapy); gestoses of pregnant women; fetoplacental insufficiency and delay of pre-natal growth of a fruit; an asthenic syndrome, a condition of reconvalescence after the postponed somatic and infectious diseases, during the postoperative period; atsetonemichesky syndromes of various genesis; for improvement of ossification in complex therapy of osteoporosis and fractures of bones; gipergomotsisteinemiya; as means of replacement therapy by a carnitine at a hemodialysis; the prevention and treatment of the neyropatiya and encephalopathy caused by use of antitubercular drugs of the GINK group (an isoniazid, etc.).

Route of administration and doses:

Drug is accepted inside to or after food. It can be washed down with water, tea or fruit juice. To adults and children 15 years are more senior appoint inside 1-2 capsules 3 times a day after food. To children at the age of 5-15 years appoint on 1 capsule 2 times a day. Reception of the contents of 1 capsule once a day which are previously dissolved in 50-100 ml of any fruit juice or sweet water is recommended to children from 1 year to 5 years. At difficulty of a proglatyvaniye of the capsule (children, patients during the postoperative period, faces which had a stroke and so forth) also Kardonat it is necessary to dissolve in the above-stated way. At treatment of states with reduced appetite it is better to accept drug in 15-20 minutes prior to meal. The average duration of a course of treatment makes from 3 weeks to 3 months.

Features of use:

It is not necessary to exceed the recommended drug doses.

Pregnancy and feeding by a breast. Drug is widely used at pregnant women in complex treatment of gestoses and fetoplacental insufficiency. During use of drug of negative influences on mother and a fruit it is not recorded.

Influence on an opportunity to drive the car or to work with difficult mechanisms. Does not influence.

Side effects:

Drug is usually well transferred, but in rare instances, as a rule, at individual hypersensitivity, the skin itch, abdominal distention, dispeptic frustration, a cardiopalmus, excitement, fluctuations of arterial pressure can be noted.

Interaction with other medicines:

At simultaneous use with a levodopa its therapeutic action due to interaction with piridoksaly can decrease. Kardonat can potentsiirovat action of antihypertensives, cardiac glycosides, peripheral vazodilatator, insulin and other gipoglikemiziruyushchy means.


Hypersensitivity to drug components, malignant new growths. Children's age till 1 year.


Tachycardia, dispeptic frustration, excitement, increase or the lowering of arterial pressure which are disappearing later drug withdrawals and not demanding holding medical actions are possible.

Storage conditions:

To store at a temperature from 15 °C to 25 °C. To store in the place, unavailable to children.
Period of validity — 2 years. The deadline of the validity is specified on packaging after the words "Use to..."

Issue conditions:

Without recipe


On 30 and 60 capsules in plastic containers and cardboard packs.

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