Subcorneal пустулез Sneddona-Wilkinson
Contents:
Description:
Subcorneal пустулез Sneddona-Wilkinson - the chronic recurrent disease which is found to a bowl at women is more senior than 40 years.
The disease was described for the first time in 1956 by the English dermatologists of Sneddon and Wilkinson. Until recently in literature the question was discussed whether the disease of an independent nosological form of a dermatosis is or under his mask pustular psoriasis, herpetiform impetigo of Gebr, a pustular form of dermatitis of Dyuringa and some other diseases of skin disappear.
Reasons of a subcorneal pustulez of Sneddona-Wilkinson:
The reasons and pathogeny of a subcorneal pustulez are unknown. In developing of a disease an important role is played by the accompanying infections, immunological and endocrine disturbances.
Symptoms of a subcorneal pustulez of Sneddona-Wilkinson:
The beginning of a disease is sometimes connected with the hormonal disturbances accompanying a thyrotoxicosis, pregnancy and childbirth at some patients - with mental injuries. Skin of a trunk and proximal departments of extremities is surprised generally. Rashes are presented by the pustules surrounded with a narrow rim of a hyperemia, sometimes grouped. Pustules are quickly opened, and result of what in a clinical picture the polycyclic erosion covered with crusts with scraps of tires of pustules on the periphery prevail. After healing of zroziya often there is a hyperpegmentation. The disease has more high-quality current in comparison with other forms of generalized pustulez, the condition of patients is broken slightly. The combination to a gangrenous pyoderma is described.
Subcorneal пустулез it is characterized by formation of superficially located pustules - phlyctenas which arise on the erythematic basis, have tendency to group and a herpetiform arrangement. Favourite localization of rashes - skin of a trunk, extremities, inguinal and axillary folds. Tires of pustules quickly burst, and their contents shrink in yellowish crusts on which periphery there are scraps of a corneous layer of epidermis. After permission of elements there are pinkish, and then poorly pigmented spots in the beginning. In contents of phlyctenas akantolitichesky cells are found. Nikolsky's symptom can be positive. Emergence of rash and its further development usually is not followed by subjective feelings, Sometimes there is a non-constant and insignificant itch of skin. Pustules in typical cases are sterile. Mucous membranes are surprised exclusively seldom. The disease flows is long, with remissions. General condition of patients satisfactory. Aggravations arise in the summer more often.
Histopathology of a subcorneal pustulez. Pustules are located direct under a corneous layer that is most characteristic of this dermatosis. In an upper part actually skin are noted only the most insignificant phenomena of a nonspecific inflammation.
Treatment of a subcorneal pustulez of Sneddona-Wilkinson:
There are no effective therapeutic methods of treatment. Use antibiotics, sulphones, glucocorticoids, retinoids, phototherapy or a combination of phototherapy to retinoids. Outwardly appoint the aniline dyes and ointments containing corticosteroids and antibiotics.
