Allopyrinolum
Application instruction:
Allopyrinolum – antigouty medicine, promotes reduction of concentration of uric acid.
Form of release and structure
Allopyrinolum is issued in tablets a dosage of 100 and 300 mg.
Indications to use
Drug is appointed at diseases to which the increased content of uric acid is peculiar (hyperuricemia):
- Gout;
- Stones in uric ways and kidneys.
The indication to use of Allopyrinolum is primary and secondary hyperuricemia which develops at:
- Disturbances of exchange of purines and pyrimidines;
- Acute leukosis;
- To lymphosarcoma;
- Chronic myeloid leukosis;
- Lesh-Nikhena's syndrome;
- Psoriasis;
- Extensive injuries;
- Adverse reactions at treatment by glucocorticoids and their synthetic analogs;
- Chemotherapy of tumors.
Contraindications
According to the instruction, Allopyrinolum has the following contraindications to use:
- Hypersensitivity to drug components;
- The expressed renal and liver failure;
- Pregnancy and period of a lactation.
Drug is not appointed to children up to 15 years, except cases of performing cytostatic therapy of malignancies and treatment of heavy fermental disturbances.
Route of administration and dosage
According to the instruction, Allopyrinolum should be accepted inside after food. The dosage is established individually and averages 100-900 mg a day for adults and 100-400 mg or 10-20 mg/kg a day for children, depending on expressiveness of symptoms of a disease and the general condition of the patient. The standard daily rate of drug should be broken into 2-4 receptions.
Side effects
According to the instruction, Allopyrinolum in certain cases can cause the following by-effects:
- From system of digestion: diarrhea, vomiting, nausea, dyspepsia, abdominal pains, a superactivity of transaminases in blood serum, hepatitis, stomatitis;
- From cardiovascular system: bradycardia, arterial hypertension;
- From the central and peripheral nervous system: headaches, weakness, dizziness, drowsiness, spasms, depression, neuropathies, vision disorder, cataract;
- From urinogenital system: intersticial nephrite, hamaturia, hypostases, uraemia;
- From system of a hemopoiesis: thrombocytopenia, aplastic anemia, agranulocytosis, leukopenia;
- From endocrine system: impotence, infertility, diabetes mellitus, gynecomastia;
- Allergic manifestations: rash, itch, hyperemia of integuments, arthralgia, temperature increase, eosinophilia, Lyell's disease, Stephens-Johnson's syndrome;
- Dermatological reactions: alopecia, furunculosis, decolouration of hair.
Special instructions
With extra care persons should use drug with disturbances of functions of kidneys and a liver and with hyperfunction of a thyroid gland.
During treatment drug recommends to use not less than 2 liters of liquid a day.
Use of Allopyrinolum demands the increased care at management of transport and difficult mechanisms.
For the period of passing of a course of treatment it is necessary to exclude alcohol intake.
Analogs
Drug analogs at the moment do not exist.
Conditions and periods of storage
Allopyrinolum is recommended to be stored in the place protected from impact of a sunlight at air temperature not above 30 °C.
The period of validity of drug makes 3 years of date of production.
Name of drug
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