Tseftriakson

Tseftriakson – cephalosporin of the 3rd generation.

Structure and form of release of Tseftriakson

Drug produce in the form of powder for preparation of solution in glass bottles on 1 g containing active agent – цефтриаксон 1 g.

Pharmacological action

According to the instruction Tseftriakson is the semi-synthetic antibiotic belonging to cephalosporins of the 3rd generation. Drug is steady against action beta лактамаз, and also gram-negative and gram-positive microorganisms. Possesses broad bactericidal action.

Indications to use

Tseftriakson according to the instruction appoint at such infectious and inflammatory diseases as:

• wound fevers;

• infectious diseases of skin and soft tissues;

• meningitis;

• infectious diseases at patients with the weakened immunity;

• sepsis;

• infectious diseases of joints and bones;

• the disseminated Lyme's borreliosis at early and late stages;

• infectious diseases of abdominal organs (infection of bilious ways and GIT, peritonitis);

• infectious diseases of urinary tract and kidneys;

• infectious diseases of bodies of a small pelvis;

• infectious diseases of an ear, throat, nose;

• gonorrhea;

• infectious diseases of generative organs;

• infectious diseases of respiratory tracts;

The indication to Tseftriakson is prevention of infections after the performed operations.

Contraindications

Tseftriakson's use is contraindicated at hypersensitivity to cephalosporins.

According to reviews Tseftriakson it is necessary to appoint with care at renal failures and a liver, at NYaK, at the colitis and enteritis caused by reception of antibacterial medicines and also to newborn children with a hyperbilirubinemia.

During Tseftriakson's reception according to indications it is forbidden to take alcoholic drinks.

Route of administration of Tseftriakson and mode of dosing

According to the instruction Tseftriakson apply to intravenous or intramuscular administration.

To children 12 years are more senior and the adult appoint treatment Tseftriaksony in a dosage of 1-2 g once a day. At especially heavy infections increase in a daily dosage up to 4 g is allowed.

The newborn aged up to two weeks the dosage makes 20-50 mg on weight kg once a day. The maximum daily dosage makes 50 mg on weight kg.

To babies and children up to 12 years Tseftriakson's dosage makes 20-80 mg on weight kg once a day.

To children weighing more than 50 kg the dosage is calculated, as well as for adults.

Dosages of 50 mg on kg of weight and more at intravenous administration enter kapelno throughout, at least, half an hour.

Duration of treatment depends on indications to Tseftriakson. After an eradikation of the activator and normalization of body temperature treatment by Tseftriakson should be continued on an extent of 2-3 days.

At bacterial meningitis at babies the dosage of drug makes 100 mg/kg of weight once a day.

At Lyme's borreliosis to children 12 years are more senior and the adult appoint 50 mg to weight kg once a day. Duration of treatment by Tseftriakson makes two weeks.

At gonorrhea Tseftriakson is according to reviews effective in a dosage of 250 mg intramusculary once.

For prevention of infections during the postoperative period the drug is administered in a dosage 1-2 g once for one or one and a half hours before operation.

Side effects

According to reviews Tseftriakson causes the following side reactions:

• Allergies: fever or fever, urticaria, eosinophilia, bronchospasm, serum disease, exudative mnogoformny erythema, acute anaphylaxis, skin rash, itch.

• System of a hemopoiesis: leukopenia, anemia, neutropenia, leukocytosis, thrombocytosis, lymphopenia, hemolitic anemia, thrombocytopenia, hypocoagulation.

• System of digestion: meteorism, lock or diarrhea, nausea, vomiting, abdominal pains, disturbance of flavoring feelings, pseudomembranous coloenteritis, dysbacteriosis, abnormal liver function.

• Urinary system: anury, renal failure, oliguria.

• Local reactions: at intravenous administration – morbidity on the vein course, phlebitis, at intramuscular – pain in the place of a prick.

In addition to above-mentioned side reactions Tseftriakson according to reviews can cause nasal bleeding, dizziness, superinfection, a headache and candidiasis.

Medicinal interaction of drug Tseftriakson

At simultaneous use of Tseftriakson with:

• the medicines reducing aggregation of thrombocytes there is an increased risk of bleedings;

• anticoagulants action of the last amplifies;

• the risk of development of nephrotoxic effect arises "loopback" diuretics;

Tseftriakson's use during pregnancy and breastfeeding

Treatment by Tseftriakson at pregnancy is possible only according to strict indications.

Using drug in the period of a lactation it is necessary to stop breastfeeding.

Storage conditions

Tseftriakson treats list B drugs. Store it at the room temperature in the dry place not longer than three years.