Differin

Differin – outside medicine with komedonolitichesky and antiinflammatory action.

Form of release and structure

• Gel for external use of 0,1%: white color (on 30 g in plastic tubas, in a cardboard pack 1 tuba);
• Cream for external use of 0,1%: white color (on 30 g in plastic tubas, in a cardboard pack 1 tuba).

Active agent: адапален, in 1 g of gel and 1 g of cream – 1 mg.

Gel excipients: dinatrium эдетат, carbomer 940 P, half-oxameasures 182, phenoxyethanol, sodium hydroxide, methylparahydroxybenzoate, propylene glycol, the water purified.

Cream excipients: глицерол, a methyldextrose macrogoal sesquistearate, squalane natural, dinatrium эдетат, phenoxyethanol, пропилпарагидроксибензоат, циклометикон, methyldextrosums sesquistearate, sodium hydroxide, methylparahydroxybenzoate, carbomer 974P (934 P), the water purified.

Indications to use

Differin – drug for treatment of acne rash (easy degree – as monodrug, average and heavy degree – as a part of complex therapy along with antibacterial and anti-androgenic agents).

Also it is applied to therapy of comedones.

Contraindications

• Skin new growths;
• Damages and burns of skin;
• Seborrheal dermatitis;
• Eczema;
• Children's age;
• Pregnancy and lactation;
• Simultaneous use of drugs of systemic action from group of retinoids;
• Hypersensitivity to drug components, retinoids or synthetic analogs of retinoic acid.

Route of administration and dosage

Differin is applied outwardly. Drug is applied pointwise on inflammatory elements or, if necessary, on all person. It is forbidden to rub means in skin! Before putting gel/cream it is necessary to clean a face (without use of soap and spirit lotions).

It is necessary to use drug 1 time a day, it is desirable for the night. The therapeutic effect is shown within 4-8 weeks of treatment, permanent improvement is noted 3 months of therapy later.

According to the recommendation of the doctor a repeated course can be conducted.

Side effects

Side effects are more often shown at the beginning of Differin's use and over time decrease. As a rule, reactions are reversible and do not demand drug withdrawal.

Possible undesirable phenomena: irritation, a peeling and a xeroderma, burning and an itch in the place of application, an erythema, eczema, an exacerbation of acne rash, contact dermatitis, allergic conjunctivitis.

Special instructions

In the form of gel Differin is recommended to apply to people with fat type of skin, in the form of cream – with dry skin.

It is necessary to put means with the thinnest layer, excess of drug if necessary can be removed by means of a napkin. It is important to know that from excess amount of drug the effect amplifies, but expressiveness of side effects increases.

It is possible to apply Differin on face skin, area of a decollete, shoulders and a back.

During drawing means it is necessary to be careful not to allow its hit in eyes, on a mucous membrane of a nose and a red border of lips.

In case of bad portability of drug or emergence of irritation it is recommended to reduce the frequency of applications or to suspend treatment before disappearance of unpleasant symptomatology.

Differin increases probability of emergence of sunblisters therefore during therapy it is necessary to avoid stay in the sun. In need of solar exposure it is necessary to take a break in drug use (not to put means 1 day to and 1 day after exposure, and also during its carrying out).

Cold and wind can promote strengthening of irritation of skin during Differin's use therefore it is recommended to avoid long stay on the street in bad weather or to try to protect as much as possible skin from influence of negative factors of the environment.

It is not necessary to apply at the same time means which dry skin: salicylic acid, drugs of zinc or sulfur, spirit means, and also spirits.

Differin applied in the evening it is possible to combine with the drugs for treatment of acne rash applied in the morning.

At an excessive xeroderma it is possible to use the moistening means containing panthenol – it will help to improve health, to remove tightness and burning of skin, to reduce expressiveness of side effects.

Cosmetics during treatment it is possible to use only nekomedogenny.

If 10 weeks of use of drug later the effect is absent, it is necessary to consult with the doctor concerning expediency of continuation of therapy.

Medicinal interaction

Differin it is possible to combine with antibacterial agents of systemic action.

If necessary it is possible to use at the same time the outside drugs containing erythromycin, clindamycin phosphate, benzoyl peroxide, but to do between applications intervals (for example, Differin – in the evening, other drug – in the morning) not to allow their physical interaction.

Side effects of an adapalen strengthen drugs with the irritating and drying action: means on the basis of salicylic acid, alcohol, sulfur, zinc, resorcin.

Komedogenny oils can reduce efficiency of an adapalen.

Terms and storage conditions

To store at a temperature up to 25 ºС. Not to freeze. To protect from children.

Cream period of validity – 2 years, gel – 3 years.