Furadonin

Furadonin – the drug from group of nitrofurans breaking permeability of a cell membrane and synthesis of a protein at bacteria, rendering bactericidal, bacteriostatic effect. Drug contains active ingredient – nitrofurantoin. Has activity concerning the following microorganisms: Staphylococcus spp., Streptococcus spp., Salmonella paratyphi B, Salmonella paratyphi A, Salmonella typhi, Enterobacter spp., Escherichia coli, Proteus, Shigella sonnei. In clinical trials high antibacterial performance of Furadonin is proved.

Indications to Furadonin's use

In the instruction to Furadonin such indications to use are specified:

• therapy of the infectious and inflammatory pathology of urinary tract caused by microorganisms, sensitive to Furadonin: pyelitis, pyelonephritis, urethritis, cystitis;
• prevention of infectious pathology during the carrying out urological operations, tsistoskopiya, catheterizations.

Contraindications to Furadonin's use

According to the instruction to Furadonin, this drug is contraindicated at:

• hypersensitivity to nitrofurantoin;
• chronic heart failure;
• chronic renal failure;
• cirrhosis;
• chronic hepatitis;
• acute porphyria;
• insufficiency glyukozo-6-fosfatdegidrogenazy;
• pregnancies, lactations;
• aged up to 1 month.

Route of administration, dosage

Furadonin is intended for oral administration. This drug in the tableted form is produced. It is recommended to wash down Furadonin's tablet with the large volume of water. The one-time dosage of Furadonin makes 0,1-0,15g. Frequency rate of reception – 3-4 times a day. The maximum daily dosage makes 0,6 g, one-time – 0,3. The average duration of a course of therapy – 7 days. The dosage in a specific clinical situation, and also duration of therapy is defined by the doctor. The dosage in case of preventive and antirecurrent use makes from 1 to 2 mg/kg. According to indications Furadonin can be appointed in pediatrics in a dosage from 5 to 8 mg/kg a day. The daily dosage is appointed in four receptions.

Side effect

At Furadonin's use emergence of allergic reactions (rash, a volchanochnopodobny syndrome, an arthralgia, a mialgiya, an eosinophilia, a Quincke's disease, an anaphylaxis), vomitings, nausea, dizzinesses, a headache, an adynamy, a nystagmus, an asthma, a bronkhoobstruktivny syndrome, intersticial changes of pulmonary fabric, fever, drowsiness, thorax pain, cough, pancreatitis, hepatitis, a cholestatic syndrome, a peripheral neuropathy, a pseudomembranous coloenteritis is registered. Emergence of a multiformny erythema, abdominal pains was extremely seldom noted.

Side effects sometimes serve as the reason of negative comments on Furadonin from patients, however when using drug according to the instruction and under medical control he is quite well had, and easy side effects do not demand drug withdrawal.

Furadonin's use during pregnancy

Drug Furadonin is contraindicated at pregnancy, a lactation. In need of treatment by Furadonin in the period of a lactation it is recommended to resolve an issue of the termination of natural feeding.

Furadonin's interaction with other drugs

At simultaneous use of the antiacid drugs (containing magnesium trisilicate), and also Acidum nalidixicum the antibacterial effect of Furadonin decreases. It is impossible to apply Furadonin with antibiotics of group of ftorkhinolon. At use of the medicines blocking canalicular secretion the antibacterial effect due to decrease in concentration of drug in urine decreases. At the same time Furadonin's toxicity also amplifies.

Overdose

At Furadonin's overdose vomiting develops. At treatment of overdose of this drug the hemodialysis and an artificial diuresis is effective.

Responses

Comments on Furadonin from patients and doctors positive as this drug has high performance at infectious pathology of uric ways, and at rational use in an adjusted dosage Furadonin is safe.

Storage conditions

Drug Furadonin needs to be stored at the room temperature out of access for children.

Special instructions

When using Furadonin's in treatment of the patients having anemia, a diabetes mellitus, disturbances of electrolytic balance, a hypovitaminosis In the probability of development of a peripheral neuropathy increases.

Furadonin is not used for treatment of purulent paranephrites, prostatitises, and also pathology of cortical substance of kidneys.

For decrease in risk of development of side effect from a GIT it is recommended to accept drug along with food or milk.

Before use of drug it is necessary to study the instruction to Furadonin. Use of this medicine is possible only on doctor's orders.