Pyrogenal

Pyrogenal – drug with immunomodulatory action.

Form of release and structure

Dosage forms of production of Pyrogenal:

• Suppositories rectal: a homogeneous consistence, yellow-white color, have the cone-shaped form with the pointed end, diameter – to 1 cm (on 5 or 10 pieces of one concentration in blister strip packagings, on 1 packaging in a cardboard pack; a set of 5 pieces of different concentration (2 pieces on 100 mkg, 1 piece on 150 mkg, 2 pieces on 200 mkg) in blister strip packagings, on 1 packaging in a cardboard pack; a set of 12 pieces of different concentration (on 3 pieces on 50, 100, 150 and 200 mkg) in blister strip packagings, on 1 packaging in a cardboard pack);
• Solution for intramuscular introduction: colourless, transparent (on 1 ml in ampoules, on 10 ampoules of one concentration in a cardboard pack complete with an ampoule knife).

Is a part of 1 suppository:

• Active ingredient: bacterial (from Salmonella typhi cells) липополисахарид – 50, 100, 150 or 200 mkg;
• Additional components: lanolin, cocoa butter, the purified water.

Is a part of 1 ml of injection solution:

• Active ingredient: bacterial (from Salmonella typhi cells) липополисахарид – 10, 25, 50 or 100 mkg;
• Additional components: buffer phosphatic saline solution (рН 6,7-7,3).

Indications to use

All dosage forms

• Liver diseases in a chronic current;
• Burn disease;
• Strictures of ureters and urethra;
• Adhesive desease of an abdominal cavity;
• Prostatitises and uretrita in a chronic current;
• Venereal diseases;
• Secondary infertility;
• Diseases of appendages of a uterus of an inflammatory etiology.

Suppositories (in addition)

• Human papillomavirus infection;
• Incomplete recovery after the postponed acute viral and bacterial diseases (immunorehabilitation and immunoprevention).

Solution for injections (in addition)

• Traumatic damages peripheral and central nervous system;
• Herpesviridae infection of eyes;
• Tuberculosis in a slow form in a rassasyvaniye phase;
• Chronic diseases of skin, including psoriasis;
• Iridocyclites;
• Opacification of a cornea;
• Uveites;
• Need of carrying out pyrotherapy (as the pyrogenic drug).

Contraindications

All dosage forms

• Feverish diseases in an acute current;
• Pregnancy;
• Hypersensitivity to drug components.

Solution for injections (in addition)

• Chronic diseases in a stage of a decompensation and an aggravation, except the diseases which are the indication to purpose of Pyrogenal;
• Blood diseases;
• Lactation period.

At chronic diseases of cardiovascular system, kidneys, and also diabetes Pyrogenal is appointed under observation of the doctor.

In the presence of anamnestic data on febrile spasms or at convulsive readiness use of drug is possible against the background of performing anticonvulsant treatment.

Route of administration and dosage

Suppositories
In this dosage form Pyrogenal is applied rektalno.

Single dose – 1 suppository a day. Drug, depending on appointment of the doctor, is applied daily or every other day.

Single initial/maximum dose – 50/200 mkg.

If there are no other appointments of the doctor, Pyrogenal is applied with gradual increase in a dose: 50, 100, 150 and 200 mkg, at this suppository of one concentration it is necessary to apply 3 times (only 12 pieces on a course).

If drug is used as monotherapy for immunorehabilitation and immunoprevention at incomplete recovery after the postponed acute bacterial and viral diseases, usually appoint concentration of 50 or 100 mkg (5-10 suppositories to a course).

On doctor's orders perhaps combined use with injection administration of Pyrogenal.

Solution for injections
The drug is administered intramusculary.

Frequency rate of use – once a day. Injections should be carried out every other day. In case of need before introduction drug is dissolved by 0,9% with sodium chloride solution for injections. Solution cannot be stored in the opened ampoule.

The doctor appoints a therapeutic dose individually.

Initial adult single dose – 2,5 mkg. Further it is gradually increased by 2,5-5 mkg. As much as possible – 100 mkg a day.

To children Pyrogenal appoint 0,5-1,5 mkg in a single dose. Further it is gradually increased by 0,5-1,5 mkg or 2,5 mkg (depending on age). As much as possible – 25-30 mkg a day.

Duration of a course makes 10-30 injections for adult patients and 10-15 injections – for children. In 2-3 months carrying out repeated courses is possible.

If Pyrogenal is appointed for a pyrotherapy, solution should be entered once a day. Injections on doctor's orders carry out in 1-2 days. An initial dose – 5-10 mkg, gradually increase it to 100-150 mkg.

Side effects

As a rule, drug is transferred without development of side reactions.

Suppositories
In some cases perhaps slight increase of temperature (do37-37,6 °C) and development of an easy indisposition.

Solution for injections
Possible side effects:

• Seldom: the temperature increase to 37,5 °C proceeding with a slight indisposition and a fever. This state can proceed 3-8 hours. The dose which caused it in the next days should be repeated before the termination of reaction to its introduction (as a rule, 1-3 injections), then the dose is consistently increased;
• Very seldom: the temperature increase to 39,5 °C proceeding with a strong fever, a headache, back pains. This state can proceed 6-8 hours, then it passes independently. In this case the dose needs to be lowered.

The reactions described above when using Pyrogenal for a pyrotherapy are allowed.

Special instructions

To children 5 years are younger and patients need to appoint more senior than 60 years injection solution of Pyrogenal in the reduced dose. Its increase is possible only under observation of the specialist and at good tolerance of drug.

Medicinal interaction

Pyrogenal can be combined with all drugs which are usually used for treatment of the specified diseases.

At use as a part of complex therapy Pyrogenal strengthens effect of the specific drugs used at chemotherapy.

Terms and storage conditions

To store in protected from light, the place, unavailable to children, at a temperature of 2-10 °C.

Period of validity – 2 years.