Retinolum acetate

Retinolum acetate – vitamin A.

Form of release and structure

Dosage forms:

• drops for intake and external use of 3,44% and 8,6%: oily liquid from dark yellow till light yellow color with transparent structure, without rancid smell (on 10, 15, 30, 50 ml in glass bottles of dark color or on 10, 30 or 50 ml in bottles with a cover dropper, in a cardboard pack 1 bottle);
• solution for intake and external use of oil 3,44% and 8,6%: transparent from dark yellow till light yellow color oily liquid without rancid smell (on 10, 15, 30, 50 or 100 ml in glass bottles of dark color or on 10 ml in a bottle dropper, in a cardboard pack 1 bottle; on 10 ml (3,4% of solution) in a polymeric bottle, in a cardboard pack 1 bottle);
• capsules: yellow color, spherical shape, without mechanical pollution and leak-ins; contents of capsules – oily liquid from light yellow till dark yellow color, in a smell are absent rancidity (on 10 pieces in a blister strip packaging, in a cardboard pack of 1-3 or 5 packagings; on 25 or 50 pieces in glass jars of dark color, in a cardboard pack of 1 bank).

For intake and external use of 3,44% and 8,6% contains in 1 ml of drops:

• active agent: Retinolum acetate (including butyl hydroxytoluene and peanut butter) 100 000 International units (ME) and 250 000 ME respectively;
• auxiliary components: butylhydroxyanisole, sunflower oil (sunflower oil the refined deodorized).

For intake and external use of oil 3,44% and 8,6% contains in 1 ml of solution:

• active agent: Retinolum acetate of 100 000 ME (34,4 mg) and 250 000 ME respectively;
• auxiliary components: the frozen sunflower oil refined deodorized brands P.

Contains in 1 capsule:

• active agent: Retinolum acetate solution for intake and external use of oil 8,6% – 0,132 ml (33 000 ME);
• auxiliary components: sunflower oil the refined deodorized;
• structure of a cover: glycerin (глицерол), methylparahydroxybenzoate (нипагин), gelatin, dye quinolinic yellow (E-104).

Indications to use

Use of Retinolum of acetate is shown at A avitaminosis, a hypovitaminosis and as a part of complex therapy:

• eye pathologies: a hemeralopia, a pigmental retinitis, a xerophthalmia, eczematic defeats a century, a keratomalacia at the accompanying deficit of vitamin A;
• diseases and damages of skin: ulcers, ichthyosis, psoriasis, hyperkeratosis, tilotichesky (mozolevidny, horn) eczema, subacute and acute stages of eczema, neurodermatitis, burns, frostbites, erosion, cracks, wounds.

Besides, to intake and external use oil and capsules apply solution as a part of complex therapy:

• seborrheal dermatitis, tuberculosis cutis;
• gastrointestinal diseases: the peptic ulcer of a stomach and duodenum, erosive gastroduodenit;
• catarrhal and infectious and inflammatory (including chronic forms) diseases (including measles, dysentery, tracheitis, flu, bronchitis).

Also capsules accept at treatment of cirrhosis, and appoint drops as a part of complex therapy of atopic dermatitis.

Contraindications

• acute inflammatory diseases of skin;
• cholelithiasis;
• A hypervitaminosis;
• chronic pancreatitis;
• pregnancy period;
• age up to 7 years;
• individual intolerance of components of drug.

With care, only after consultation of the attending physician, it is possible to apply Retinolum acetate at cirrhosis, alcoholism, a viral hepatitis, a renal failure, at advanced age.

Besides, patients should be careful at purpose of solution and capsules with heart failure of II and III degrees, at nephrite.

Route of administration and dosage

Use of Retinolum of acetate is carried out only under observation of the attending physician.

Drops for intake and external use of 3,44% and 8,6%
Drops accept inside after food, 10-15 minutes later.

The recommended dosing:

• easy and average degree of avitaminosis: the adult – on 11,35mg (33 000 ME) that corresponds to 0,33 ml of drops with concentration of 3,44% (13 drops from an eyedropper or 10 drops from a cover dropper) or 0,13 ml of 8,6% of drug (5 drops from an eyedropper or 4 drops from a cover dropper) in days;
• diseases of eyes: adults – on 17,2-34,4 mg (50 000-100 000 ME) that corresponds to 0,5-1 ml of drops with concentration of 3,44% (20-40 drops from an eyedropper or 14-28 – from a cover dropper) or 0,2-0,4 ml with concentration of 8,6% (8-16 drops from an eyedropper or 6-8 – from a cover dropper) in days; children (taking into account age) – on 0,34-1,72 mg (1000-5000 ME) that corresponds to 0,01-0,05 ml of drug of 3,44% (1-2 drops from an eyedropper or 1 drop from a cover dropper) or 0,004-0,02 ml of drug with concentration of 8,6% (1 drop from an eyedropper or from a cover dropper) in days;
• skin pathologies: adults – on 17,2-34,4 mg (50 000-100 000 ME) that corresponds to 0,5-1 ml of 3,44% of drug (20-40 drops from an eyedropper or 14-28 – from a cover dropper) or 0,2-0,4 ml of drops of 8,6% (8-16 drops from an eyedropper or 6-8 – from a cover dropper) in days; children – on 1,72-6,88 mg (5000-20 000 ME) that corresponds to 0,05-0,2 ml of drops of 3,44% (2-8 drops from an eyedropper or 2-6 drops – from a cover dropper) or 0,02-0,08 ml of drug with concentration of 8,6% (1-4 drops from an eyedropper or 1-2 drops – from a cover - a dropper) in days.

The doctor determines treatment duration individually.

At treatment of ulcers, burns and frostbites it is at the same time recommended to carry out processing of sites of damage of skin by acetate Retinolum Solutio oleosa. For this purpose a day apply drug on previously cleared surface of defeat of 5-6 times and cover with a gauze. Frequency rate of frequency of greasing in process of epithelization and scarring is reduced to 1 time a day.

Solution for intake and external use of oil 3,44% and 8,6%
Solution is accepted inside, in 10-15 minutes after food (early in the morning or late at night).

The recommended dosing:

• easy and moderate severity of avitaminosis: adults – to 33 000 ME, children are more senior than 7 years – on 5000 ME in days;
• diseases of eyes: adults – on 50 000-100 000 ME a day with a concomitant use of 20 mg of Riboflavinum;
• skin pathologies: adults – on 50 000-100 000 ME, children – from 5000 to 20 000 ME in days. At treatment of burns, frostbites and ulcers, except intake, appoint local applications with drug which impose on the cleared affected areas of 5-6 times a day during the acute period of a state, then in process of healing reduce frequency rate of procedures.

The single dose should not exceed for adult 50 000 ME, for children – 5000 ME, daily – 100 000 ME and 20 000 ME respectively.

Capsules
Capsules accept inside after food late at night or early in the morning.

The recommended dosing:

• avitaminosis easy and moderate severity: on 1 piece (33 000 ME) a day;
• pathologies of eyes: adults – on 3 pieces (100 000 ME) a day in a combination from 20 mg of Riboflavinum;
• skin diseases: adults – on 3 pieces (100 000 ME) a day.

The maximum daily dose for adults – 100 000 ME.

Side effects

Against the background of Retinolum therapy by acetate development of a hypervitaminosis of A, allergic reactions is possible, at prolonged use the risk of intoxication increases.

A hypervitaminosis symptoms:

• adults: drowsiness, headache, slackness, nausea, vomiting, hyperemia of the person, disturbance of gait, ostealgia of the lower extremities;
• children: skin rashes, temperature increase, vomiting, drowsiness, perspiration.

Special instructions

Retinolum acetate cannot be applied in combination with other polyvitaminic drugs containing vitamin A not to allow a hypervitaminosis.

For adults daily requirement of Retinolum makes 0,9 mg, for children – 0,4-1 mg.

For the feeding women and children living on Far North, the dose is recommended to be raised for 50%.

Use of drug in the recommended doses does not exert impact on ability of the patient to control of vehicles and mechanisms.

Medicinal interaction

It is not recommended to appoint vitamin A drugs at long therapy tetracyclines as such combination can cause intracranial hypertensia.

At simultaneous use of Retinolum of acetate:

• oral contraceptives – promote increase in level of concentration of vitamin A in a blood plasma;
• glucocorticosteroids, salicylates – reduce risk of emergence of undesirable effects;
• колестипол, Colestyraminum, Neomycinum, mineral oils – reduce drug absorption (there can be a need of increase in a dose of Retinolum of acetate);
• изотретиноин – increases risk of development of toxic effect;
• calcium drugs – reduce the therapeutic effect, causing risk of development of a hypercalcemia;
• vitamin E – causes decrease in deposition in a liver and uses of vitamin A, toxicity of drug and its absorption, reception of high doses of vitamin E can lower vitamin A reserves in an organism.

Terms and storage conditions

To protect from children.

To store at a temperature: drops and solution – to 10 °C, the capsule – to 25 °C, in the place protected from light to protect capsules from moisture.

Period of validity: drops – 3 years, solution and capsules – 2 years.