Reserpinum

Reserpinum – the drug from group of sympatholytics having hypotensive and sedative effect, strengthening effects of analgetics and hypnagogues.

Form of release and structure

Dosage form – tablets (on 50 pieces in packaging, on 1000 pieces in a container).

Active ingredient: Reserpinum – 0,1 or 0,25 mg in 1 tablet.

Indications to use

• Arterial hypertension;
• Hyperkinetic syndrome;
• Psychoses against the background of the increased arterial pressure;
• Mental diseases of a vascular etiology.

Also Reserpinum is applied sometimes in the following cases:

• Easy forms of heart failure with tachycardia (in a combination with cardiac glycosides);
• Thyrotoxicosis (along with thyreostatic drugs, for reduction of neurovegetative frustration and an urezheniye of pulse);
• Hyper sympathicotonia;
• Persistent sleeplessness;
• Schizophrenia (in a combination with neuroleptics);
• Alcoholic psychoses.

Contraindications

• Congestive heart failure;
• Serious illness of cardiovascular system;
• Bradycardia;
• AV blockade;
• Depression;
• Ulcer colitis in an aggravation phase;
• Aggravation of a peptic ulcer of a stomach and 12-perstny gut;
• Diseases of kidneys with disturbance of their function;
• Bronchial asthma;
• Nephrosclerosis;
• Atherosclerosis of cerebral vessels;
• The period before carrying out a countershock;
• Period of pregnancy and lactation;
• Simultaneous use of monoamine oxidase inhibitors and 1 week after their cancellation;
• Hypersensitivity to drug.

Route of administration and dosage

Reserpinum should be accepted inside after food.

Specific doses and duration of treatment are defined individually.

At early stages of arterial hypertension appoint 0,05-0,1 mg 2-3 times a day. Further if necessary (but on condition of good tolerance of drug) the dose is gradually raised. The maximum daily dose – 1 mg. If within 10-14 days of hypotensive effect it is not possible to achieve, drug is cancelled. After achievement of effect the daily dose is gradually reduced: at first to 0,5 mg, then – to 0,2 mg, further – to 0,1 mg. For a maintenance therapy appoint minimal effective doses. Treatment will move courses for 2-3 months to 4 times a year.

At neurosises Reserpinum is appointed in a dose from 0,25 mg 2-3 times a day to 0,5 mg by 3-4 times a day.

At mental diseases in the first day appoint 0,25-2 mg, further depending on a clinical situation raise a daily dose to 10-15 mg.

The maximum doses for adults: one-time – 2 mg, daily – 10 mg.

Drug is shown to children depending on age and indications in a daily dose of 0,1-0,4 mg in 2-4 receptions.

Side effects

• From the alimentary system: abdominal pains, nausea, diarrhea, vomiting, ultseration mucous digestive tract; at long reception in high doses – an abnormal liver function;
• From an urinary system: increase of an urination or ischuria;
• From cardiovascular system: bradycardia; at reception in high doses – strengthening of symptoms of stenocardia;
• From the central and peripheral nervous system: dryness and puffiness of mucous membranes, fatigue, weakness, alarm, dizziness, sleeplessness or drowsiness, depressions; at reception in high doses – dreadful dreams, parkinsonism;
• Dermatological reactions: skin itch, herpes;
• Others: nose congestion, hyperemia of mucous membranes of eyes, asthma, increase in body weight, decrease in a potentiality and libido.

Special instructions

Because of a low performance and numerous side effects sympatholytics (Reserpinum including) carry to cure of the second row for arterial hypertension and psychoses.

During treatment it is necessary to control arterial pressure.

Medicinal interaction

• Beta adrenoblockers: mutual strengthening of pharmacological effects is noted;
• Adreno-and sympathomimetics: mutual decrease of the activity is noted;
• Anti-hypertensive means: the anti-hypertensive effect is exponentiated;
• Bromocriptinum: its influence on prolactin level decreases (dose adjustment is necessary);
• The alcohol and means oppressing the central nervous system: the depressive effect amplifies;
• Non-steroidal anti-inflammatory drugs (especially indometacin): anti-hypertensive action decreases;
• Anticholinergics: influence on gastric secretion decreases;
• The means causing extrapyramidal frustration: frustration amplify;
• Levodopa: its effect decreases (increase in a dose is required);
• Quinidine, cardiac glycosides: the pro-arhythmic effect develops;
• Furasolidone, Procarbazinum, and also monoamine oxidase inhibitors, including селегилин: there is a risk of development of sudden hypertensia and a hyper pyrexia.

Terms and storage conditions

To store in cool, protected from light, the place, unavailable to children.

Period of validity – 3 years.