Trichopolum

Trichopol – the synthetic means with antimicrobic and antiprotozoan action applied at treatment of serious infectious diseases.

Pharmacological action of Trichopolum

Active component of Trichopolum is metronidazole which has effect on bacteria thanks to biochemical recovery 5 nitrogroups intracellular transport proteins of the elementary and anaerobic microorganisms. The recovered 5 nitrogroup interacts with deoxyribonucleic acid of cells of an organism, inhibits synthesis from nucleic acids and destroys bacteria.

Form of release of Trichopolum

The medicine Trichopolum is released in tablets and in the form of solution:

• One tablet of Trichopolum according to the instruction contains 250 mg of metronidazole, is issued in cellular packagings in packs on 10 pieces;
• One 20 ml the ampoule transparent, with yellowish-green coloring of a medicine contains metronidazole 500 mg, hydrosodium phosphate, monohydrate of citric acid, sodium chloride, water for injections, is issued on 10 ampoules in cardboard packs;
• One 100 ml the bottle of Trichopolum contains metronidazole 500 mg, is issued in 100 ml polyethylene bottles.

Trichopolum analogs

Trichopolum analogs on active component are:

• Бацимекс;
• Klionum;
• Metrogil;
• Metron;
• Siptrogil;
• Flagyl;
• Efloranum.

On pharmacological group and the had effect treat Trichopolum analogs:

• Atrikan;
• Gayro;
• Dazolik;
• Lornizol;
• Nitazolum;
• Orniona;
• Tiberal;
• Kvinizol.

Indications to use of Trichopolum

The drug Trichopolum is used at prevention and treatment of mephitic gangrenes at surgical intervention, a combination therapy of the mixed aerobic-anaerobic infections, and also at treatment:

• Sepsis;
• Gas gangrene;
• Peritonitis;
• Gynecologic infections;
• Osteomyelitis;
• Abscesses of a small pelvis;
• Skin infections;
• Brain abscesses;
• Severe form of an intestinal and hepatic amebiasis;
• The abscessing pneumonia;
• Infections which are caused by microorganisms, sensitive to a medicine.

Trichopolum route of administration

On the basis of the instruction Trichopolum in tablets is applied inside, without chewing, in time or after food. The dosage of means depends on age and a disease, namely:

• At treatment of trichomoniasis tablets the adult and children's dosage (of 10 years) makes 1 tablet three times a day, or within a week it is necessary to take 4 pill divided into two receptions. The course of treatment a medicine if necessary can be repeated in a month;
• The same dosage is applied also at treatment of a bacterial vaginosis. In this case the single dose of eight tablets is also possible;
• At treatment of an amebiasis the medicine dosage Trichopolum makes 3 tablets three times a day for children 10 years and adults are more senior. To children 10 years, as a rule, are younger appoint the reduced dosages. Irrespective of age duration of a medical course makes five days;
• At treatment of amoebic abscess of a liver and other forms of an abenteric amebiasis usually appoint the dosage reduced twice which makes 1,5 tablets three times a day. The medical course is expected five days. The same dosage is usually applied also at treatment of an asymptomatic carriage of cysts, but duration of treatment can make 10 days;
• On one tablet of Trichopolum three times a day children accept 10 years and adults are more senior at treatment of an infection of a periodontium and acute dontogenous infections. Duration of treatment is defined by the doctor and can vary from three to seven days.

Treatment of the infections caused by anaerobic bacteria is usually begun with intravenous infusions with Trichopolum which replace then with tablets. The medicine dosage for children is more senior than 10 years and adults 2 tablets make 3-4 times a day a course of no more than 7 days.

According to indications Trichopolum is entered intravenously in cases of a heavy course of infections, or at impossible reception of a medicine inside. The adult dosage of Trichopolum according to the instruction at intravenous administration makes 500 mg with rate of administering of 5 ml a minute, with the 8th hour interval of introduction. The maximum dose makes no more than 4 g a day. For children 12 years a dosage of infusions of Trichopolum are younger makes 7,5 mg of medicine on 1 kg of body weight in 3 receptions with rate of administering of 5 ml a minute.

According to indications Trichopolum in the form of solution is not recommended to be applied to infusions with other medicines.

Contraindications to use of Trichopolum

According to the instruction Trichopolum is contraindicated to use at:

• Leukopenias;
• Renal failure;
• Liver failure;
• Organic lesion of the central nervous system;
• Hypersensitivity to active component – metronidazole and its derivatives.

The drug Trichopolum according to the instruction with care is appointed in the second and third trimesters of pregnancy. The first trimester of pregnancy and the period of a lactation are a contraindication to use of a medicine.

Side effects

Use of Trichopolum according to reviews leads to complications from various systems of an organism in overdose cases, namely:

• Digestive tract: a loss of appetite, nausea, dryness in a mouth, jaundice, a glossitis, intestinal colic, pancreatitis, stomatitis, epigastric pains, taste disturbance, locks, vomiting, anorexia, cholestatic hepatitis and diarrhea;
• Central nervous system: depression, spasms, sleep disorder, encephalopathy, headache, ataxy, hallucinations, incoordination of movements, weakness, dizziness, peripheral neuropathy, drowsiness, hyperexcitability and confusion of consciousness;
• Urinogenital system: urine discoloration, polyuria, colpodynia, vulvovaginal candidiasis, cystitis, incontience of urine and dysuria;
• Musculoskeletal device: arthralgias and mialgiya;
• Circulatory system: agranulocytosis, pancytopenia, leukopenia, thrombocytopenia and neutropenia.

Besides, Trichopolum according to reviews can cause thrombophlebitis, skin rash, fever, toxicity, a gynecomastia, a mnogoformny exudative erythema, an itch, pustulous rashes and a congestion of a nose.

Storage conditions

According to indications Trichopolum is released only on doctor's orders. It is necessary to store medicine in the unavailable to children dry, aired and protected from light hit room, at the room temperature to 25 °C.