Vazar
Application instruction:
Vazar – the drug used at arterial hypertension.
Form of release and structure
Vazar release in the form of tablets, coated (30 or 90 tablets in packaging).
Active agent – валсартан is a part of 1 tablet: yellow color of a tablet with contents – 40 and 160 mg, pink – 80 mg.
The auxiliary components which are a part of tablets: talc, magnesium stearate, monohydrate of lactose, sodium of a kroskarmeloz, microcrystallic cellulose, povidone, silicon dioxide colloid.
Indications to use
- Arterial hypertension;
- The diseases of cardiovascular system which are followed by the phenomena of chronic heart failure.
Contraindications
- Renal failure and outflow of bile;
- Cirrhosis;
- Heavy functional disturbances of a liver;
- Pregnancy and period of a lactation;
- Hypersensitivity to components.
Vazar is contraindicated to the patients who is on a hemodialysis.
Route of administration and dosage
At arterial hypertension drug is accepted once a day in an average therapeutic dose of 160 mg which if necessary can be increased twice. Perhaps simultaneous use of Vazar with other hypotensive medicines.
At chronic heart failure the initial dose of drug makes 40 mg 2 times a day. If necessary it is possible to increase a dose gradually to 160 mg 2 times a day.
After the postponed myocardial infarction the initial dose makes 20 mg 2 times a day. Gradually it is increased to 160 mg by 2 times a day.
Side effects
At Vazar's use development of such side effects as is possible:
- Accession of infections of adnexal bosoms of a nose and upper respiratory tracts (pharyngitis, antritis);
- Orthostatic hypotension.
In some cases during therapy arise: heart failure, hypotension, diarrhea, abdominal pains, cough, dorsodynia, arthritis, mialgiya, adynamy, headache, conjunctivitis.
Vazar's reception can cause development of neurologic frustration in the form of sleeplessness, depressions, a syncope, neuralgia. The hyperpotassemia and thrombocytopenia leading to developing of nasal bleedings and bleedings of other localization can be observed.
Extremely seldom during treatment develop: Quincke's disease, acute renal failure and other functional disturbances of kidneys, gastroenteritis.
Special instructions
Care at use of tablets by patients with a renal artery stenosis in case of a concomitant use of kaliysberegayushchy diuretics and drugs of potassium is required.
Use of high doses of diuretics can cause symptomatic hypotension (at the reduced volume of the circulating blood and level of sodium).
At the initial stage of treatment of chronic heart failure, at cirrhosis, in the postinfarction period and at co-administration of APF inhibitors careful use of Vazar and medical control is required.
At liver diseases the most admissible dose of drug – 80 mg.
Efficiency and safety of use of Vazar by children and teenagers is not studied.
Medicinal interaction
At simultaneous use of Vazar with kaliysberegayushchy diuretics, the potassium drugs, medicines increasing potassium level it is necessary to be careful and take measurements of potassium concentration in blood.
In case of combined use with Cimetidinum, indometacin, atenololy, furosemide, warfarin, digoxin, Hydrochlorthiazidum, Glibenclamidum and amlodipiny, applied to treatment of arterial hypertension, interaction is not observed.
At purpose of other hypotensive medicines increase in anti-hypertensive action of Vazar is possible.
Use of non-steroidal anti-inflammatory drugs, simultaneous with valsartany, leads to decrease in hypotensive action, a renal failure (has temporary reversible character). In some cases at patients with a renal failure and patients of advanced age the acute renal failure can develop.
Terms and storage conditions
To store in protected from light, the place, dry, unavailable to children, at a temperature up to 25 °C.
Period of validity – 4 years.
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