Coated tablets with the maintenance of 250 mg, 500 mg or 875 mg of amoxicillin, 125 mg of clavulanic acid and excipients: silicon of dioxide colloid, krospovidona, croscarmellose sodium, magnesium stearate, talc, MKTs. In blisters and bottles of dark glass;
Powder for preparation of suspension for intake with contents in 5 ml of ready suspension of amoxicillin and clavulanic acid in the ratio 125 mg / 31,25 mg, 250 mg / 62,5 mg, 400 mg / 57 mg and excipients: citric acid, sodium citrate, MKTs and karmelloza of sodium, xanthane gum, silicon of dioxide colloid, fragrance of wild cherry and fragrance lemon, saccharinate of sodium, Mannitolum. In bottles of dark glass;
Powder for preparation of solution for injections with contents in 1 bottle of amoxicillin and clavulanic acid in the ratio 500 mg / 100 mg, 1000 mg / 200 mg.

Indications to use

According to the instruction, Amoxiclav is appointed at treatment of the infectious and inflammatory diseases caused by microorganisms, sensitive to medicine. Drug is shown at gynecologic, dontogenous infections, and also infections:

ENT organs and upper parts of respiratory tracts, including acute and chronic sinusitis, average otitis, tonsillitis, retropharyngeal abscess, pharyngitis;
Connecting and bone tissue;
Lower parts of respiratory tracts, including chronic bronchitis, an acute bronchitis with bacterial superinfection, pneumonia;
Urinary tract;
Skin and soft tissues, including stings of animals and the person;
Bilious ways.

Use of Amoxiclav in the form of injections is shown:

At infections of an abdominal cavity;
At infections, sexually transmitted – gonorrhea, a venereal ulcer;
For prevention of development of infections after surgical interventions.

Contraindications

Amoxiclav is not appointed at the cholestatic jaundice and hepatitis connected with reception of penicillinic antibitiotik. Besides, means is contraindicated at:

Sensitivity to penicillinic drugs, clavulanic acid, amoxicillin, other components of Amoxiclav;
Infectious mononucleosis;
Lymphoid leukosis.

Amoxiclav is appointed with care at:

Pseudomembranous colitis in the anamnesis;
Liver failure;
Heavy renal failures.

The possibility of use of Amoxiclav by pregnant women and the reproaching women should be solved with the doctor individually.

Route of administration and dosage

The mode of reception of Amoxiclav and duration of therapy is defined depending on severity of an infection, age, function of kidneys of the patient and body weight. The medicine in tablets and suspension is recommended to be accepted during food that will allow to reduce risk of development of side effects from the alimentary system.

Average course of treatment – of 5-14 days. More long treatment is possible only after performing repeated medical examination.

The recommended mode of dosing of Amoxiclav in tablets for children is younger than 12 years – 40 mg/kg a day which is divided into 3 receptions. More than 40 kg are shown to children with body weight adult dosages of a medicine. For children 6 years are younger more preferably to use Amoxiclav in the form of suspension.

Two schemes of reception of Amoxiclav by adults at the easy and medium-weight course of an infection are possible:

Each 8 hours on 1 tablet of 250+125 mg;
Each 12 hours on 1 tablet of 500+125 mg.

Against the background of the heavy course of an infection and at respiratory infections it is necessary to accept each 8 hours on 1 tablet of 500+125 mg or each 12 hours on 1 tablet of 875+125 mg.

At dontogenous infections within 5 days reception of 1 tablet of 250+125 mg each 8 hours or 1 tablets of 500+125 mg each 12 hours is shown.

To newborns and children up to 3 months Amoxiclav is appointed in the form of suspension at the rate of 30 mg/kg a day (on amoxicillin). Medicine is taken by each 12 hours. For observance of a dosage it is necessary to use the dosing pipette attached to packaging.

The daily dosage for children is more senior than 3 months makes:

At easy and moderately severe diseases – from 20 mg/kg a day;
At the heavy course of an infection and at treatment of lower respiratory tract infections, average otitis, sinusitis – to 40 mg/kg (on amoxicillin) in day.

It must be kept in mind that when calculating dosages it is necessary to rely not on age of the child, and on the mass of his body and severity of disease.

Side effects

Use of Amoxiclav can lead to development of side effects:

System of a hemopoiesis: anemia, eosinophilia, thrombocytopenia, agranulocytosis, leukopenia;
Alimentary system: diarrhea, meteorism, gastritis, nausea, dyspepsia, glossitis, stomatitis, anorexia, coloenteritis, vomiting;
Nervous system: alarm, inadequate behavior, overexcitation, spasms, the confused consciousness, sleeplessness, a hyperactivity, dizziness, a headache;
Integuments: urticaria, hypostasis, rash; more rare – exfoliative dermatitis, an epidermal toxic necrolysis, Stephens-Johnson's syndrome, a multiformny erythema;
Urinary system: intersticial nephrite, hamaturia.

Development of superinfection is also possible (including candidiasis).

In most cases side effects against the background of performing therapy by Amoxiclav have slight and passing character.

Special instructions

Reception of Amoxiclav during food reduces probability of development of side effects from digestive tract.

At course therapy it is necessary to control functions of a liver, a hemopoiesis and kidneys.

Against the background of heavy renal failures the doctor has to correct the mode of dosing or increase an interval between reception of a medicine.

Analogs

Analogs of Amoxiclav are:

On active agent – Baktoklav, Klamosar, Arlette, Panklav, Medoklav, Liklav, Augmentin, Rapiklav, Fibell, Ekoklav, Amovikomb, Amoksivan;
On the action mechanism – Libaktsil, Oksamp, Santaz, Ampioks, Tazotsin, Timentin, Sulatsillin, Ampisid.