Azidrop

Azidrop – the antibacterial drug of a broad spectrum of activity belonging to a class of azaleads active concerning gram-positive bacteria (except for the strains steady against erythromycin); it is applied in ophthalmology.

Form of release and structure

Dosage form – drops eye: transparent oily colourless or light yellow color liquid (on 0,25 g in one-dose bottles from polyethylene of low density, 6 soldered among themselves in the form of a tape of the bottles packed into packages from the combined material; 1 package in a pack cardboard).

Contains in 1 g of drops:

• Active ingredient: azithromycin a dihydrate – 15 mg (14,3 mg of azithromycin are equivalent);
• Auxiliary components: triglycerides srednetsepochny.

Indications to use

Azidrop – an antibiotic for treatment of the conjunctivitis caused by the microorganisms sensitive to azithromycin, including Chlamydia trachomatis.

Contraindications

Drug is contraindicated to children till 1 year, to patients with hypersensitivity to any component of Azidrop or other antibiotics of group of macroleads.

Route of administration and dosage

Drops Azidrop are applied locally.

Drug needs to be dug in in a conjunctival sac of the affected eye on 1 drop 2 times a day (in the morning and in the evening) within 3 days.

Dose adjustment is not required to children till 1 year at tracheomatous conjunctivitis. At purulent bacterial conjunctivitis at children 2 years are younger than experience of use of drug insufficiently.

Precautionary measures:

• To carefully wash hands before instillation and after the procedure;
• Not to concern a tip a dropper of an eye, a century and other surfaces;
• To throw out one-time a tube dropper even if in them there is a solution.

Side effects

Classification of side effects by frequency: very often (more than 1/10), it is frequent (more than 1/100, less than 1/10), infrequently (more than 1/1000, less than 1/100), is very rare (less than 1/10000):

• From an organ of sight: very often – eye discomfort after an instillation (a pricking, burning and an itch); often – feeling of a foreign body in an eye, feeling of adhesion a century, sight misting; infrequently – dacryagogue; very seldom – the century, a conjunctiva hyperemia, an erythema, a keratitis, eczema, conjunctivitis (including allergic), an eye allergy swelled;
• From immune system: very seldom – a Quincke's edema, hypersensitivity reactions.

Special instructions

System exposure to azithromycin insignificant therefore the adverse effect of drug on the course of pregnancy is not expected. Azidrop can be applied to treatment of pregnant women on doctor's orders after careful assessment of a ratio of advantage and possible risks.

There are limited data that azithromycin is emitted with breast milk, however considering low system availability and low doses of Azidrop, impact on an organism of newborns extremely insignificant therefore drug can be used when breastfeeding.

Drops Azidrop should not be accepted inside or to enter in the form of injections.

The drug cannot be administered peri-and intraokulyarno.

In case of development of allergic reactions treatment should be stopped.

At co-administration of other ophthalmologic drugs Azidrop the last should dig in, in 15 minutes after instillation of other means.

At the conjunctivitis caused by Neisseria gonorrhoeae, and the conjunctivitis of not tracheomatous origin caused by Chlamydia trachomatis system treatment is required.

Azidrop is not recommended to appoint to children of 1-2 years, except for need of treatment of tracheomatous conjunctivitis.

This drug is not intended for prevention of bacterial conjunctivitis at newborns.

Each patient to whom Azidrop is appointed needs to be warned that the course of treatment lasts 3 days. Even if after the last instillation there are symptoms of bacterial conjunctivitis, therapy cannot be continued.

After an instillation perhaps passing misting of sight, in this case right after instillation (before sight recovery) is recommended to refrain from driving and performance of potentially dangerous types of works.

Patients with bacterial conjunctivitis should not carry contact lenses.

Medicinal interaction

Researches on an occasion of interaction of Azidrop with specific medicines were not conducted.

Due to the topical administration of Azidrop the defined concentration of azithromycin in a blood plasma are absent therefore interaction with one of drugs which interacted with azithromycin at its intake is not expected.

Terms and storage conditions

To store in the place, unavailable to children, at a temperature up to 25 ºС.

Period of validity – 1,5 years.