Bicillinum

Pharmacological action

Bicillinum is a natural antibiotic of group of penicillin. Drug suppresses synthesis of a cellular cover and wall of microorganisms that interferes with growth and reproduction of bacteria. Bicillinum is active concerning many gram-positive and some gram-negative microorganisms, however the majority of gram-negative bacteria, viruses, mushrooms, mycobacteria, the elementary is steady against effect of this drug.

Bicillinum represents powder for preparation of the solution intended for intramuscular introduction. Depending on structure distinguish three types of this drug:

• Bicillinum 1 contains бензатин benzylpenicillin in concentration of 300, 600 or 1200 thousand. Pieces.
• Bicillinum 3 consists of a benzatin of benzylpenicillin, benzylpenicillin of sodium salt and benzylpenicillin of novocainic salt. All substances are presented in equal proportions – on 200 or 400 thousand. Pieces.
• Bicillinum 5 represents a combination of a benzatin of benzylpenicillin and benzylpenicillin of novocainic salt in a proportion of 1200 and 300 thousand. Piece respectively.

Slow absorption after introduction and receipt in blood throughout the long period is characteristic of Bicillinum 1. Drug begins to work in 3-6 hours after use, and reaches the maximum concentration in 12-24 hours.

Bicillinum 3 is also slowly hydrolyzed, after single use concentration of drug, sufficient for treatment, in blood is observed for 6-7 days.

The maximum concentration Bicillinum 5 is reached during the first hours after introduction and remains at the level of 28 days, sufficient for effective therapy. An insignificant part of Bicillinum is transformed, removed generally by kidneys. Drug is capable to get through a placental barrier and into breast milk.

Indications to use of Bicillinum

Bicillinum, the instruction confirms, is applied in the following cases:

• infections which were caused by organisms, sensitive to penicillin (especially when long therapeutic concentration of drug in blood is necessary);
• prevention of rheumatism;
• infections of ENT organs and respiratory tracts (tonsillitis, streptococcal pharyngitis, lung and focal fevers, scarlet fever);
• erysipelatous inflammation;
• syphilis, frambeziya, gonorrhea.

Application instruction of Bicillinum

Use of Bicillinum is possible only by intramuscular introduction on considerable depth. Solution is prepared just before use. According to the instruction, Bicillinum can be diluted with isotonic solution of sodium of chloride, sterile water or 0,25-0,5% Procainum solution. Before administration of drug the patient has to be checked for portability of this antibiotic.

Prevention and treatment by Bicillinum of 1 infectious diseases is done with in the form of introduction of 300 or 600 thousand weekly (once a week). Pieces. Use of Bicillinum 1 in a dose of 1,2 million is possible. The piece, but then frequency rate of introductions is reduced to 2 times a month. Treatment of rheumatism provides use of 2,4 mln units 2 times a month, and prevention of a recurrence of rheumatism – on 600 thousand. Piece weekly for 6 weeks. The individual mode of dosing is selected at syphilis, at the same time the recommended dose makes 2,4 million. The piece which it is necessary enters 2-3 times with observance of 8-day breaks between use of Bicillinum 1.

Bicillinum 3 is entered in a dose of 300 thousand. Piece (for once two injections in different buttocks can be made) or 600 thousand. Pieces. Introduction of Bicillinum 3 in a smaller dosage is made 1 time in 4 days, and in a bigger dosage – 1 time in 6 days. The course of treatment of primary and secondary syphilis provides 7 injections on 1,8 million. Piece, an exception is the first introduction – 300 thousand. Piece: the second introduction of Bicillinum 3 is carried out in a day after the first injection, and the subsequent – 2 times a week.

Bicillinum to 5 adults and children is more senior than 8 years it is recommended to enter 1 time in 4 weeks in a dose of 1,5 million. Pieces. To children be more senior than 8 years the dose of Bicillinum 5 can is reduced to 1,2 million. Pieces. Use of drug in a dose of 600 thousand is possible. The piece to children is younger than 8 years – 1 times in 3 weeks.

Side effects

The instruction to Bicillinum contains a list of negative reactions which can be caused drug use:

• headache, dizziness, sonitus;
• bronchospasm;
• diarrhea, nausea, glossitis (language inflammation), stomatitis, abnormal liver function;
• intersticial nephrite;
• dysfunctions of a myocardium, fluctuation of arterial pressure;
• hemolitic anemia, thrombocytopenia, leukopenia, agranulocytosis, eosinophilia;
• urticaria, skin rashes, dermatitis, hypostases, fever, fever, acute anaphylaxis, Quincke's disease of Quincke;
• the superinfection (at the weakened patients) caused by drug resistance of microflora.

Contraindications to use of Bicillinum

Use of Bicillinum is forbidden to patients with hypersensitivity to penicillin. To patients with hypersensitivity to novocaine Bicillinum 3 and Bicillinum 5 is not appointed.

Care is necessary at drug use by the patient suffering:

• small tortoiseshell;
• bronchial asthma;
• hay fever.

In the instruction to Bicillinum information on use of drug during pregnancy and feeding by a breast is absent. Considering that active ingredients of this antibiotic are capable to get into breast milk and through a placental barrier, use of Bicillinum has to be carried out only to destination and under control of the doctor.

Additional information

In order that use of Bicillinum did not provoke development of fungal infections ascorbic acid and vitamins of group B, and if necessary – levorinum and nystatin can be appointed.

The instruction to Bicillinum recommends to make storage of drug in the dry and cool place ^{(not higher than 200C)}.

Suitable Bicillinum is considered within 3 years from the moment of production.