Glibenclamidum

Glibenclamidum – peroral hypoglycemic means.

Form of release and structure

Dosage form – tablets: a ploskotsilindrichesky form, with dividing risky, color, white or white with a subtle gray or yellow shade (on 10 pieces in a blister strip packaging, in a cardboard pack of 1, 2, 3 or 5 packagings; on 20, 30 or 50 pieces in banks from polymer or dark glass, in a cardboard pack of 1 bank).

Active ingredient – glibenclamide, in 1 tablet – 5 mg.

Auxiliary components: lactoses monohydrate (sugar milk), magnesium stearate, povidone (polyvinylpirrolidone low-molecular medical), potato starch.

Indications to use

Use of drug is shown for treatment of a diabetes mellitus of the 2nd type at inefficiency of a dietotherapy at adults.

Contraindications

• Diabetes mellitus of the 1st type;
• Infectious diseases;
• The expressed renal failures and/or a liver;
• Disturbances of microcirculation in a severe form;
• Ketoacidosis, diabetic prekoma and coma;
• Period of pregnancy and breastfeeding;
• Carrying out serious surgeries;
• Hypersensitivity to sulfanamide drugs and derivatives of sulphonylurea.

With care appoint drug: to patients with pathology of a liver and/or kidneys, including in the anamnesis; at an alcoholism; in case of dysfunctions of a thyroid gland, adrenal glands; at feverish states.

Route of administration and dosage

Pill is taken inside in 20-30 minutes prior to or in 2 hours after food.

The doctor appoints a dose individually depending on severity of diabetes, age of the patient and level of a glycemia.

Usual average daily dose – from 2,5 to 15 mg, with frequency rate of reception 1-3 times. In rare instances drug is used in a dose more than 15 mg a day, it significantly does not influence increase in hypoglycemic effect.

Initial dose for patients of advanced age – 1 mg a day.

Initial dose of drug upon transition from guanyl guanidines – 2,5 mg a day.

For compensation of disturbances of carbohydrate metabolism after cancellation of guanyl guanidines Glibenclamidum dose in case of need can be raised on 2,5 mg every 5-6 days. Transition to the combined treatment by glibenclamide and guanyl guanidines should be planned in the absence of such compensation within 4-6 weeks.

Side effects

Use of drug can cause the following side effects:

• From endocrine system: a hypoglycemia up to a coma (correct purpose, observance of the mode of dosing and a diet reduces degree of probability of its development);
• From a nervous system: seldom – a headache, dizziness, fatigue, paresis, weakness, sensitivity disturbances;
• From the alimentary system: feeling of weight in epigastric area, nausea, diarrhea; seldom – a cholestasia, functional disturbances of a liver;
• From system of a hemopoiesis: seldom – hemopoiesis disturbances, development of a pancytopenia;
• Allergic reactions: itch, skin rash;
• Dermatological reactions: seldom – a photosensitization.

Special instructions

Treatment needs to be carried out under systematic control of content of glucose to blood and its daily removal with urine.

During administration of drug it is necessary to avoid alcohol intake, otherwise development of the expressed hypoglycemia, disulfiramopodobny reactions is possible.

In case of development of a hypoglycemia it is necessary to compensate deficit of glucose urgently. Patients in consciousness accept glucose or solution of sugar inside, at a loss of consciousness to the patient enter glucose intravenously or a glucagon – intravenously, intramusculary or subcutaneously. To avoid a recurrence, the food allowance of patients during this period has to be enriched with carbohydrates.

Medicinal interaction

Strengthening of hypoglycemic effect of drug can be promoted by simultaneous use of sulfonamides of long action, beta adrenoblockers, Allopyrinolum, anabolic means, Cimetidinum, cyclophosphamide, Clofibratum, Isobarinum, monoamine oxidase inhibitors (MAO), salicylates, tetracyclines, chloramphenicol, etanolsoderzhashchy drugs.

Decrease in effect of Glibenclamide and risk of development of a hyperglycemia in the patients who are at the same time accepting Chlorpromazinum, barbiturates, diazoxide, fenotiazina, Phenytoinum, acetazoleamide, glucocorticoids, a glucagon, sympathomimetic means, indometacin, nikotinata in high doses, saluretics, contraceptives for intake and estrogen, lithium salts, hormones of a thyroid gland, high doses of purgatives is possible.

Terms and storage conditions

To store in the unavailable to children, dry, protected from light place at a temperature not above 25 °C.

Period of validity – 3 years.