Chloropyraminum

Chloropyraminum – drug of group of antihistamines, a blocker histamine H1 receptors.

Pharmacological action of Chloropyraminum

Therapeutic action of Chloropyraminum is based on its ability to block m-holinoretseptory and histamine H1 receptors, rendering at the same time antipruritic, antiallergenic, sedative, cholinolytic, spasmolytic and somnolent influences.

Chloropyraminum is capable to weaken spazmogonny effect of a histamine on smooth muscles of intestines and bronchial tubes thanks to what hypotensive action of a histamine and its impact on permeability of vessels decrease.

Effect of drug is also directed to the prevention of development of allergic reactions of immediate type and simplification of their current.

High speed of absorbability allows Hloropiramin to reach a concentration maximum during 2 h after reception. The therapeutic effect at the same time lasts from 4 to 6 h.

Form of release of Chloropyraminum

In the medical Chloropyraminum networks it is available in two forms: in the form of tablets and solution for in oil and in/in introductions.

The tablets Chloropyraminum are issued in number of 20 pieces, the content of active agent in them makes 25 mg.

Solution for in/in and introductions in oil represents transparent liquid with a scarcely noticeable yellowish or greenish shade. There is a characteristic smell. Solution is packed into ampoules, the mass of active agent in which makes 20 mg. Packaging contains 5 or 10 ampoules.

Indications to use of Chloropyraminum

As appears from the instruction to Chloropyraminum, drug has therapeutic effect concerning the following types of diseases:

• pollinosis or hay fever;

• dermatosis of allergic type;

• allergy to medicines;

• rhinitis and conjunctivitis of allergic types;

• the allergic reactions which arose after stings of insects;

• serum disease;

• Quincke's disease.

Contraindications

Numerous medical reviews of Chloropyraminum warn about existence of a number of contraindications at which administration of drug is extremely not recommended. Their list is given below:

• aggravation of a peptic ulcer of a stomach;

• bad attacks of bronchial asthma;

• combination of administration of drug to MAO inhibitors;

• prostate hyperplasia;

• pregnancy and period of a lactation;

• children age less than 1 month;

• hypersensitivity to drug components, in particular, to ethylene diamine derivatives (including to Chloropyraminum).

Administration of drug is not contraindicated to the following groups of persons, however it is necessary to take it with caution:

• patients of advanced age;

• patients with the diagnosed insufficiency of functions of a liver and/or heart diseases;

• patients with a peptic ulcer of a duodenum and/or stomach;

• the patients accepting medicines, the oppressing TsNS functions;

• the patients suffering from an ischuria.

The instruction to use of Chloropyraminum

Drug is recommended to be accepted inside in the following dosage: frequency of reception of Chloropyraminum for adults makes 3-4 times a day on 25 mg. For children the dosage is adjusted depending on age: the initial dose makes 5 mg – for children from one month to a year of life; from a year to 6 years – 10 mg; to 20 mg – to children aged from 7 up to 18 years. The maximum daily dose at the same time is calculated by a formula: 2 mg/kg of body weight of the child. To kids, whose age Chloropyraminum is contraindicated less than one month.

The dosage at in oil or in introduction for adults varies within 20-40 g.

Side effects

Before use of drug it is important to study the instruction to Chloropyraminum since during treatment emergence of undesirable effects is possible. Their list is given below:

• drowsiness, slackness, weakness, easy tremor of extremities. Side effects at children can be shown in the form of excitement, concern, sleeplessness, irritability;

• dryness in an oral cavity, a lock, diarrhea, vomiting, nausea;

• developing of arrhythmia, tachycardia is in rare instances possible, there is also a probability of increase in the ABP;

• an allergy in the form of an itch and skin rash;

• difficulties at an urination.

Overdose

Use of Chloropyraminum and analogs of medicine in inadequate quantity is capable to cause overdose which symptoms following:

• at children the overdose is shown in the form of uneasiness, emergence of hallucinations, an athetosis, an ataxy, spasms, a mydriasis, the real estate of pupils, a dermahemia of the person, a hyperthermia. In rare instances – a coma, a collapse;

• at adults the condition of block and a depression, or excitement of TsNS, in rare instances – hallucinations, disorders of coordination, lack of reaction of pupils to light, a hyperthermia is possible.

Treatment means systematic therapy which includes reception of Phenaminum, caffeine, antiepileptic means, and also resuscitation actions together with ventilation of the lungs. The specific antidote is absent.

Special instructions

Categorically the concomitant use of drug with alcohol is not recommended.

Strengthening of symptoms a reflux esophagitis is possible at reception of Chloropyraminum before going to bed.

Long reception of Chloropyraminum is capable to cause disturbances of a hemogenesis that is expressed in such symptoms as causeless temperature increase, pallor of integuments, the laryngitis, emergence of hematomas which are hardly stopped and unusual bleedings, ulcers on a mucous membrane of a mouth. In these cases it is necessary to see a doctor immediately.

Chloropyraminum and analogs of drug are capable to give the distorted picture at statement of allergological tests, in this regard it is recommended to suspend drug intake some days before the test.

The combined reception of Chloropyraminum and ototoksichny means is capable to mask ototoxicity manifestations.

During administration of drug it is necessary to refuse the types of activity demanding high concentration of attention.

Chloropyraminum analogs

To the drugs close on a way of action to Chloropyraminum, Suprastinum belongs.

Storage conditions

Chloropyraminum is recommended to be stored in the darkened place where temperature does not exceed 25 °C, far from access for children. The period of validity makes 4 years.