Penkrofton contains in one tablet of drug 200 milligrams of mifepristone. As excipients there are a lactose, microcrystallic cellulose, corn starch, aerosil and calcium stearate.

Tablets have light yellow color with a greenish shade. The mramornost is possible.

Pharmacological effect of drug Penkrofton

Penkrofton at the level of receptors blocks activity of progesterone.

Pharmacokinetics

After one-time administration of drug Penkrofton in number of 600 milligrams its maximum concentration in an organism makes 1,98 milligrams on liter. This concentration in ninety minutes is reached. Absolute bioavailability makes 69%. Linkng with plasma proteins makes 98% that is reached in eighteen hours.

Indications of drug Penkrofton

According to the instruction Penkrofton is intended for medicamentous abortion on early terms (up to 42 days of an amenorrhea).

Contraindications to Penkrofton's use

Contraindications to drug use Penkrofton are:

pregnancy which exceeds 42 days of an amenorrhea on term;
suspicion on an extrauterine pregnancy;
long therapy by corticosteroids;
chronic adrenal insufficiency;
anemia;
treatment by anticoagulants;
hemorrhagic disturbances;
existence of a hem on a uterus;
diseases of a vagina of inflammatory character;
the pregnancy which appeared after cancellation of hormonal contraception or owing to use of intrauterine contraception;
hypersensitivity to mifepristone;
the smoking women who are more than 35 years old;
hysteromyoma.

Route of administration and doses

Drug Penkrofton is appointed for intake on 600 milligrams (three tablets on 200 milligrams) to one reception under control of the doctor. After reception the patient has to be under observation of the doctor not less than two hours.

After 8-14 days conduct clinical examination by means of ultrasonography. If the effect of the use is absent for the 14th day (the developing pregnancy or incomplete abortion) to the patient make vacuum aspiration. Further conduct a histologic research of aspirate.

According to the instruction Penkrofton has to be accepted only under control of the highly skilled, trained and certified doctors, and also in the presence of the necessary resuscitation equipment.

Side effects of Penkrofton

During a procedure there can be plentiful bleeding during which it is necessary to carry out immediately surgical intervention (curettage), and also there can be pain in the bottom of a stomach, inflammations of appendages and a uterus.

According to the instruction Penkrofton can cause discomfortable feelings in the bottom of a stomach, a headache, a weak state, nausea and vomiting, dizzinesses, diarrhea, a hyperthermia.

Use during pregnancy and feeding by a breast

If it is necessary to use drug Penkrofton during the lactic period, it is necessary to stop breastfeeding for two weeks after Penkrofton's reception.

Precautionary measures

According to the instruction Penkrofton patients should not appoint with a liver or renal failure. Also it is necessary to use carefully drug at patients with bronchial asthma, cardiovascular diseases and HOBL.

Overdose

Пенкрофтон необходимо применять только под наблюдением врача In case of overdose Penkrofton can provoke development of adrenal insufficiency of acuity.

Penkrofton's interaction with other drugs

Drug Penkrofton should not be used with NPVS (including, acetylsalicylic acid) as they can exert impact on Penkrofton's efficiency.

Responses

Reviews of Penkroftona speak about his high performance in abortion. But it is necessary to do it only in the specialized place under strict supervision of the doctor.

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