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Pentaminum

Pentaminum – a ganglioblokator, renders hypotensive, veno-and arteriodilatiruyushchy action.

Form of release and structure

Dosage form – solution for intramuscular (in oil) and intravenous (in/in) introductions of 5%: colourless transparent liquid (on 1 ml or 2 ml in glass neutral ampoules, in a cardboard box of 10 ampoules or in a blister strip packaging on 5 ampoules, in a cardboard pack 2 packagings).

Active ingredient of Pentaminum – an azametoniya bromide, in 1 ml – 50 mg.

Auxiliary components: water for injections.

Indications to use

  • Hypertensive crisis;
  • Enterospasms, biliary tract, peripheral vessels;
  • Wet brain;
  • Renal colic;
  • Bad attacks of bronchial asthma (for stopping);
  • Kauzalgiya;
  • Eclampsia;
  • Fluid lungs.

Besides, use of Pentaminum is shown in anesthesiology – for creation of controlled hypotonia, in urology – for simplification of cystoscopic researches at men.

Contraindications

  • Myocardial infarction;
  • Arterial hypotension;
  • Thrombophlebitis;
  • Closed-angle glaucoma;
  • Degenerative changes of the central nervous system;
  • Liver and/or renal failure.

Route of administration and dosage

Solution of Pentaminum is intended for in oil and in/in introductions.

The recommended dosing:

  • The vasospasms and other pathologies which are not demanding emergency measures: in oil – on 50 mg 2-3 times a day, if necessary a single dose increase up to 75-100 mg. The maximum single dose – 150 mg, daily – 450 mg of drug;
  • Wet brain, hypertensive crisis, fluid lungs: in oil – to 100 mg or slowly in/in (under control of the arterial pressure (AP)) – 10-25 mg (0,2-0,5 ml of solution) divorced in 20 ml of 5% of solution of glucose or isotonic solution of sodium chloride;
  • The managed arterial hypotonia: before operation in/in kapelno enter 40-60 mg, if necessary increase in a dose to 120-180 mg is shown.

Side effects

  • Alimentary system: dryness in a mouth;
  • Nervous system: weakness, dizziness;
  • Cardiovascular system: tachycardia, orthostatic hypotension;
  • Organ of sight: mydriasis.

Special instructions

After introduction of Pentaminum the patient needs to be within 1-2 hours in a prone position, otherwise the risk of development of orthostatic hypotension increases.

Medicinal interaction

At simultaneous use of Pentaminum:

  • Tricyclic antidepressants, ephedrine, phenylephine hydrochloride reduce hypotensive action a bromide azametoniya;
  • Anti-hypertensive means, including not depolarizing muscle relaxants, increase effect of drug.

Terms and storage conditions

To protect from children.

To store in the place protected from light at a temperature up to 18-20 °C.

Period of validity – 5 years.

 
 
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